Effects of supplemental zinc source and level on antioxidant ability and fat metabolism-related enzymes of broilers

Liu, Z. H.; Lü, Lin; Wang, R. L.; Lei, Hulong; Li, Shaozheng; Zhang, L. Y.; Luo, Xugang

doi:10.3382/ps/pev251

Cited by 68 publications

(45 citation statements)

References 27 publications

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“…In accordance with the present findings, Liu et al. () found that dietary supplementation of Zn at 60 mg/kg in the corn–soy diet improved Cu‐Zn‐SOD in the breast and thigh muscles ( p < .05) and liver ( p < .01) of chickens. Zinc is important for the function and structure of Cu‐Zn‐SOD, which comprised more than 90% of SOD and protects the body from free radical and oxidative stress (Noor, Mittal, & Iqbal, ; Wang et al., ).…”

Section: Resultssupporting

confidence: 92%

“…In agreement with these results, serum Zn level was positively correlated with Zn level in the diet (Darlen & Arlette, ). Dietary supplementation of Zn improved Zn status by increasing the content of Zn in the breast, liver and thigh muscles of chickens (Liu et al., ). Contradicting results were obtained by Bartlett and Smith () who found that there was no significant effect of dietary Zn levels on plasma Zn concentration in chickens exposed to heat stress.…”

Section: Resultsmentioning

confidence: 99%

“…Serum levels of lipid parameters were significantly (p < .001) affected by Zn-Met supplementation except HDL-cholesterol ( T A B L E 4 Effect of graded levels of Zn methionine on egg quality parameters of Hisex Brown laying hens from 22 to 34 weeks of age muscles of chickens (Liu et al, 2015). Contradicting results were obtained by Bartlett and Smith (2003) who found that there was no significant effect of dietary Zn levels on plasma Zn concentration in chickens exposed to heat stress.…”

Section: Lipid Profile and Zinc Content Of The Serummentioning

confidence: 94%

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Effect of dietary supplementation of organic zinc on laying performance, egg quality and some biochemical parameters of laying hens

El‐Hack

Alagawany

Amer

et al. 2017

Animal Physiology Nutrition

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This study was conducted to evaluate the effects of zinc methionine (Zn-Met) supplementation on the performance, egg quality, antioxidant status and some biochemical parameters of blood serum in laying hens from 22 to 34 weeks of age. A total of 120 Hisex Brown laying hens of 22-week-old were randomly allocated into five treatments with six cage replicates for each (four hens/replicate). Dietary treatments consisted of the basal diet with no Zn-Met supplementation (control group) and basal diet supplemented with 25, 50, 75 or 100 mg Zn-Met/kg diet. No significant differences were observed on body weight, body weight gain or feed conversion ratio due to dietary Zn-Met supplementation. However, highly significant impact was observed on daily feed intake. Egg number, egg weight and egg mass were increased in the group fed diet supplemented with the highest level of Zn-Met (100 mg/kg of diet) as compared to other groups. All egg quality traits were statistically (p > .05 or .01) affected as a response to dietary Zn-Met supplementation except egg shape index, shell percentage and yolk index. In comparison with the control group, dietary supplementation of 25, 50, 75 or 100 mg Zn-Met/kg decreased serum triglyceride and LDL-cholesterol levels. Serum cholesterol level was increased with all dietary levels of Zn-Met in comparison with the control group. Dietary Zn-Met supplementation increased the serum content of zinc, where the highest values were recorded with 50 and 100 mg Zn-Met/kg diet. Dietary Zn-Met levels did not affect the antioxidant indices in blood serum except for the activity of copper-zinc superoxide dismutase (Cu-Zn-SOD). The activity of Cu-Zn-SOD was increased with Zn-Met supplementations with no differences among supplemental zinc levels. It is concluded that dietary Zn-Met supplementation reduced serum triglyceride, LDL-cholesterol and increased Zn status and resulted in promoting antioxidant ability of laying hens, and the addition of 100 mg Zn-Met/kg to layer diet was appropriate for improving the above parameters in addition to egg production indices and Haugh unit score.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Lipid Profile and Zinc Content Of The Serummentioning

confidence: 94%

See 1 more Smart Citation

Effect of dietary supplementation of organic zinc on laying performance, egg quality and some biochemical parameters of laying hens

El‐Hack

Alagawany

Amer

et al. 2017

Animal Physiology Nutrition

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“…The obtained data are in harmony with those reported by Ahmadi et al (2014) who indicated that nano zinc supplementation decreased MDA concentration compared to control. Also, Liu et al (2015) stated that supplemental zinc decreased malondialdehyde (MDA) level in the liver. We could speculate that dietary Zn might strengthen the oxidative defenses and decrease the MDA content of muscles, which would contribute to higher quality and longer shelf life of meat.…”

Section: 6antioxidant Enzyme Activitymentioning

confidence: 99%

Effect of Dietary Replacement of Inorganic Zinc by Organic or Nanoparticles Sources on Growth Performance, Immune Response and Intestinal Histopathology of Broiler Chicken

El-Katcha¹,

Soltan²,

Elbadry³

2017

AJVS

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Key words:Broiler chickensOrganic zinc -Nano zinc -Growth performance -Immune response -Intestinal health.Two hundred and twenty-five one day-old avian chicks were used to investigate the effect of different dietary supplemental zinc sources and levels on growth performance, blood picture and biochemical parameters, immune response, carcass characteristics and intestinal morphology of broiler chickens. Birds were randomly allocated into 9 groups which fed on the experimental basal diet supplemented with different zinc sources and levels; group 1 was fed basal diet supplemented with (60 ppm) inorganic zinc oxide, while groups 2, 3, 4 and 5 were supplemented with (60, 45, 30 or 15 ppm) organic zinc (polysaccharide-zinc complex) respectively and groups 6, 7, 8 and 9 were supplemented with (60, 45, 30 or 15ppm) zinc oxide nanoparticles respectively. Broiler chickens fed 60 or 45 ppm organic zinc improved growth performance while, lower supplementation levels (30 or 15ppm) had no significant effect. Moreover, zinc nanoparticles supplementation at 60, 45 or 30 ppm improved growth performance while lower level (15ppm) significantly reduced broiler performance and feed efficiency parameters. Using organic or nano zinc reduced total feed intake of broiler chicken. Organic or nano zinc supplementation non-significantly reduced blood serum lipids and increased GOT or GPT concentrations compared with those fed on diet supplemented with inorganic zinc. Moreover, organic or nano zinc had no significant effect on antioxidant enzyme activity while reduced abdominal fat weight. Organic zinc or nano zinc supplementation improved phagocytic activity, antibody production against Newcastle Disease vaccine, lymphoid organs weight and improve intestinal villi length, width and crypt depth of broiler chicken.

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“…Likewise, there was considerable digestion and absorption of minerals with a nutritional organic source of trace minerals (zinc, copper, manganese, iron, calcium, and phosphorus) compared to an inorganic source in pigs [34]. To our knowledge, there have been several reports that showed varied responses of animals supplemented with Zn and Cu from different sources [1][2][3]35,36], but the triazine hydrazone complexes had not been investigated yet. Our findings, therefore, could contribute a new potential organic complex of trace minerals that would facilitate the research of the growth-promoting products and develop some novel pharmacological drugs.…”

Section: Discussionmentioning

confidence: 99%

Zinc and Copper with New Triazine Hydrazone Ligand: Two Novel Organic Complexes Enhanced Expression of Peptide Growth Factors and Cytokine Genes in Weaned V-Line Rabbit

Elokil

Imbabi

Mohamed

et al. 2019

Animals

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Simple Summary: Zinc and Copper are two important trace minerals, which are involved in numerous vital biological activities in animal's body, such as enzyme activation and enhancement of immune function, growth, reproduction, DNA synthesis, cell division, and neurotransmitters production. Recently, the application of trace mineral organic complexes in animal feed received much more attention than the inorganic sources. The organic sources can contribute significantly to improving animals' health and reproduction, as the minerals are more biologically available and absorbable than they are when coming from the inorganic sources. In this study, three injectable varieties of Zn and Cu supplementation, sulfate, inorganic (loaded with montmorillonite), and novel organic (ligand with triazine hydrazone), were tested with weaned rabbits. The results revealed that these three mineral types vary at the most biological responses, and only one category of our novel organic complexes provided consistent animal performance improvement, including weight gain, serum antioxidant, meat quality, intestine morphometry, and the expression of peptide growth factors and cytokine genes. To our knowledge, this is the first work on the Zn and Cu with triazine hydrazone ligand as two organic complexes in rabbits.Abstract: Two novel transitional organic Zn/Cu complexes based on a new biocompatible bidentate triazine-hydrazone ligand (Thz) was designed, synthesized, and evaluated in this study. This study evaluated the effects of injecting 60 mg of Zn and 40 mg of Cu in three different forms, twice per week, for eight weeks on growth performance, expression of growth factors and cytokine genes, carcass yield, blood biochemicals, and intestinal morphology in weaned rabbits. The tested complexes were sulfate (Cu/ZnSO 4 ), montmorillonite (Cu/Zn-Mnt), and triazine hydrazone (Cu/Zn-Thz). A total of 60 Animals 2019, 9, 1134 2 of 17 V-line weaned rabbits at four weeks of age were assigned to four treatments (n = 15), which were intramuscularly injected with 0.5 mL of either (1) saline (control) or saline containing (2) Cu/ZnSO 4 , (3) Cu/Zn-Mnt, or (4) Cu/Zn-Thz. Compared to the controls, the rabbits injected with Cu/Zn-Thz showed a higher (p < 0.01) growth rate, carcass yield (p < 0.05), and liver expression of insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), fibroblast growth factor-1 (FGF1), and transforming growth factor beta-1 (TGFB1) (p < 0.05), as well as better jejunum morphometric variables (p < 0.05). On the other hand, mRNA of FGF1, TGF1, TCIRG1, and adenosine deaminase (ADA) were higher expressed (p < 0.05) in the spleen tissues of Cu/Zn-Mnt group. Collectively, the results indicated that our novel synthesized organic complexes of Zn/Cu-Thz proved to be a suitable feed supplement, as it increased rabbit productive performance through enhancing expression of peptide growth factors and cytokine genes.

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Effects of supplemental zinc source and level on antioxidant ability and fat metabolism-related enzymes of broilers

Cited by 68 publications

References 27 publications

Effect of dietary supplementation of organic zinc on laying performance, egg quality and some biochemical parameters of laying hens

Effect of dietary supplementation of organic zinc on laying performance, egg quality and some biochemical parameters of laying hens

Effect of Dietary Replacement of Inorganic Zinc by Organic or Nanoparticles Sources on Growth Performance, Immune Response and Intestinal Histopathology of Broiler Chicken

Zinc and Copper with New Triazine Hydrazone Ligand: Two Novel Organic Complexes Enhanced Expression of Peptide Growth Factors and Cytokine Genes in Weaned V-Line Rabbit

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