Effects of Supplementation with Ginger (Zingiber officinale Roscoe) on Serum Glucose, Lipid Profile and Oxidative Stress in Obese Women: A Randomized, Placebo-Controlled Clinical Trial

Attari, Vahideh Ebrahimzadeh; Mahluji, Sepideh; Jafarabadi, Mohammad Asghari; Ostadrahimi, Alireza

doi:10.15171/ps.2015.35

Cited by 29 publications

(13 citation statements)

References 37 publications

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“…This fact can be seen by the increase in the HOMA-IR values, although without statistical significance. At higher doses and intervention periods, researchers have shown that ginger has contributed to lower insulin resistance in people with T2DM, which is favorable to reduce complications related to the disease ( 10 , 13 , 17 , 26 - 27 ) .…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

Carvalho

Neto

Araújo

et al. 2020

Rev. Latino-Am. Enfermagem

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Objective: to evaluate the effectiveness of ginge (Zingiber officinale) in reducing blood sugar and lipid levels in people with type 2 diabetes. Method: a randomized and double-blind clinical trial conducted with people with type 2 diabetes in primary care facilities. The study included individuals aged between 20 and 80 years old, using oral antidiabetic drugs and with HbA1c levels between 6.0% and 10%. The participants were paired 1:1, allocated in two distinct groups, and randomized in blocks, based on their HbA1c levels. In the experimental group, the participants used 1.2g of ginger and, in the control group, 1.2g of placebo, daily for 90 days. The primary outcome was a reduction in fasting blood sugar and HbA1c, and the secondary outcome was a reduction in lipids and HOMA-IR. 103 individuals completed the study, 47 in the experimental group and 56 in the control group. Results: the participants in the experimental group showed a greater reduction in the blood glucose and total cholesterol values compared to the control group. Conclusion: the use of ginger can help in the treatment of people with diabetes, and data support the inclusion of this herbal drug in the clinical practice of nurses. RBR-2rt2wy

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Section: Discussionmentioning

confidence: 99%

Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

Carvalho

Neto

Araújo

et al. 2020

Rev. Latino-Am. Enfermagem

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show abstract

“…Further, in a randomized double-blind placebo-controlled clinical study, the effects of a daily intake of 2 g of ginger powder in 40 obese women was assessed. It was shown that ginger treatment had a non-significant reducing effect on serum glucose, a slight positive effect of ginger powder consumption on serum glucose, and a significant effect on TG when compared to placebo [ 84 ]. Another randomized double-blind placebo-controlled trial conducted in individuals with type-2 diabetes for 2 months examined the effects of ginger powder on glycemic parameters and found that ginger significantly increased insulin sensitivity, but had no effect on FBG and HbA1c [ 85 ].…”

Section: Herbal Approaches To Management In Metabolic Syndromementioning

confidence: 99%

“…In a randomized double-blind placebo-controlled trial, it was noted that ginger significantly decreased serum LDL and TGs in participants with type-2 diabetes [ 85 ]. Whilst another showed that a 2 g ginger treatment significantly reduced TG levels in the blood compared to the placebo group in obese women [ 84 ]. Moreover, a randomized double blinded study examined the effects of 3 g of ginger powder for 45 days on CVD patients in Iran, concluding that ginger powder caused a significant reduction in TGs, cholesterol, LDL, and very low-density lipoprotein (VLDL) levels in the blood [ 88 ].…”

Section: Herbal Approaches To Management In Metabolic Syndromementioning

confidence: 99%

The Role of Bioactive Compounds from Dietary Spices in the Management of Metabolic Syndrome: An Overview

et al. 2021

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Metabolic syndrome (MetS) is a combination of physiologically dysregulated parameters that can include elevated fasting blood glucose, high blood pressure, central obesity, increased triglyceride levels, insulin resistance, diabetes, elevated low density lipoprotein levels, and reduced high density lipoprotein levels in the blood. Effective clinical management of MetS is critical as it is strongly associated with long lasting and fatal complications in patients. Alongside standard care of lifestyle changes and medication, dietary supplements derived from herbal resources could be an alternative therapeutic strategy that is safe, efficient, culturally acceptable, and has few side effects. Of the dietary supplements, spicy foods have always been considered a great source of functional bioactive compounds. Herbal therapy is broadly used in many countries as a treatment or as a preventive measure in the management of MetS risk factors, including blood glucose, blood pressure, and blood lipid levels. Herein, an attempt is made to evaluate the recent studies in the management of MetS with herbal alternatives, and to explore the possibility of their use as therapeutic treatments or supplements.

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“…Zingiber officinale is a perennial plant from the Zingiberaceae family. Its rhizome (underground stem), commonly known as ginger, is widely used as a popular spice in different cultures around the world [ 16 , 17 ]. The Food and Drug Administration (FDA) recognizes ginger as a safe dietary supplement [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Ashraf

Heydari

Shams

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Primary hypothyroidism is a common disease. Some patients have persistent symptoms despite normal serum thyroid-stimulating hormone (TSH) levels. Ginger is reported to be beneficial in relieving similar symptoms. Our aim was to evaluate the efficacy of ginger supplementation in relieving persistent symptoms in these patients. In this randomized, double-blind, placebo-controlled clinical trial, 60 hypothyroid patients aged 20–60 years with normal serum TSH concentrations were randomly allocated to two equal parallel study groups of ginger (500 mg twice a day) or placebo for 30 days. Hypothyroid symptoms were evaluated as the primary outcome using the Thyroid Symptom Rating Questionnaire (ThySRQ) before and after the intervention. Anthropometric measures and laboratory indices including TSH, triglyceride (TG), total cholesterol (TChol), and fasting blood sugar (FBS) were considered as secondary outcomes. A significant lower mean total ThySRQ score (8.63 ± 5.47 vs. 15.76 ± 6.09, P < 0.001 ) was observed in the ginger group compared to the control group. Ginger led to significant improvements in the mean scores of the weight gain, cold intolerance, constipation, dry skin, appetite, memory loss, concentration disturbance, and feeling giddy or dizzy domains ( P < 0.001 ). However, no significant improvements were observed in hair loss, nail fragility, hearing, hoarseness, speech, and depression or feeling down ( P > 0.05 ). Ginger supplementation also led to a significant decrease in body weight, body mass index, waist circumference, serum TSH, FBS, TG, and TChol levels compared to the placebo. In summary according to preliminary results of this study, ginger supplementation can help relieve persistent hypothyroid symptoms. Also, it may have beneficial effects in terms of weight reduction and regulation of the FBS and lipid profile in hypothyroid patients.

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Effects of Supplementation with Ginger (Zingiber officinale Roscoe) on Serum Glucose, Lipid Profile and Oxidative Stress in Obese Women: A Randomized, Placebo-Controlled Clinical Trial

Cited by 29 publications

References 37 publications

Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

Effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial

The Role of Bioactive Compounds from Dietary Spices in the Management of Metabolic Syndrome: An Overview

Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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