Effects of supplementation with low-dose group B vitamins on clinical and biochemical parameters in critically ill patients with COVID-19: a randomized clinical trial

Majidi, Nazanin; Bahadori, Effat; Shekari, Soheila; Tajaddod, Shirin; Ajami, Marjan; Gholami, Somayeh; Shadnoush, Mahdi; Ahmadzadeh, Mina; Moghadam, Anoush Dehnadi; Hassanpour, Naeemeh; Shafahi, Hanieh; Shafie, Fatemeh; Moslem, Alireza; Doaei, Saeid; Goodarzi, Mark O.

doi:10.1080/14787210.2022.2125867

Cited by 10 publications

(18 citation statements)

References 29 publications

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“…So, the conclusion can be reached that various vitamins can decrease the severity of COVID-19. The positive effect of various vitamins on COVID-19 has also been confirmed in a number of publications [ 3 , 11 , 140 , 141 , 142 , 143 , 144 ]. It has been concluded that vitamins play an important role in the regulation of the immune response.…”

Section: Possible Causes Of Covid-19 Severitymentioning

confidence: 57%

Severe COVID-19—A Review of Suggested Mechanisms Based on the Role of Extracellular Matrix Stiffness

Kerch

2023

IJMS

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The severity of COVID-19 commonly depends on age-related tissue stiffness. The aim was to review publications that explain the effect of microenvironmental extracellular matrix stiffness on cellular processes. Platelets and endothelial cells are mechanosensitive. Increased tissue stiffness can trigger cytokine storm with the upregulated expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin IL-6, and tissue integrity disruption, leading to enhanced virus entry and disease severity. Increased tissue stiffness in critically ill COVID-19 patients triggers platelet activation and initiates plague formation and thrombosis development. Cholesterol content in cell membrane increases with aging and further enhances tissue stiffness. Membrane cholesterol depletion decreases virus entry to host cells. Membrane cholesterol lowering drugs, such as statins or novel chitosan derivatives, have to be further developed for application in COVID-19 treatment. Statins are also known to decrease arterial stiffness mitigating cardiovascular diseases. Sulfated chitosan derivatives can be further developed for potential use in future as anticoagulants in prevention of severe COVID-19. Anti-TNF-α therapies as well as destiffening therapies have been suggested to combat severe COVID-19. The inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells pathway must be considered as a therapeutic target in the treatment of severe COVID-19 patients. The activation of mechanosensitive platelets by higher matrix stiffness increases their adhesion and the risk of thrombus formation, thus enhancing the severity of COVID-19.

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Section: Possible Causes Of Covid-19 Severitymentioning

confidence: 57%

Severe COVID-19—A Review of Suggested Mechanisms Based on the Role of Extracellular Matrix Stiffness

Kerch

2023

IJMS

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“…Majidi et al 24 compared the effects of low‐dose intramuscular vitamin B injections (10 mg thiamin, 4 mg riboflavin, 40 mg nicotinamide, and 6 mg dexpanthenol) and standard are in 85 patients (Table 3). The patients’ mean age was 61 years, most were overweight, and their mean APACHE II score was 15.…”

Section: Resultsmentioning

confidence: 99%

“…15,[18][19][20] Figure 1 shows that REE generally increased with time. The weighted mean REE (kilocalories per kilogram of BW) of nonobese patients in week 1, week 2, week 3, and week 4 were approximately 21 (range: 18-25), 26 (range: 23-29), 32 (range: [19][20][21][22][23][24][25][26][27][28][29][30][31], and 29 (range: 19-29), respectively. 15,[18][19][20] The weighted mean REE (kilocalories per kilogram of adj-BW) of patients with obesity in week 1, week 2, week 3, and week 4 were approximately 19 (range: 18-20), 27 (range: 26-27), 30 (range: 27-33-25), and 29 kcal/kg, respectively.…”

Section: Energymentioning

confidence: 99%

“…They have recently gained much interest in preventing and reducing the severity of COVID-19 because of their key roles in cell function, energy metabolism, and maintenance of proper immune functions. 43 Majidi et al 24 found that supplementing critically ill patients with SARS-CoV-2 intramuscularly with a low dose of group B vitamins has no effects on biochemical and clinical parameters such as kidney function, arterial blood gas, GCS, and serum electrolytes. There was also no difference in the 30-day mortality between the intervention and the control group.…”

Section: Vitamin Bmentioning

confidence: 99%

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Macronutrient and micronutrient requirements and therapeutic effects in critically ill patients with SARS‐CoV‐2: A narrative review

Huang

Lew

2023

Nut in Clin Prac

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Background: COVID-19 can lead to critical illness and induce hypermetabolism, protein catabolism, and inflammation. These pathological processes may alter energy and protein requirements, and certain micronutrients may attenuate the associated detriments. This narrative review summarizes the macronutrient and micronutrient requirements and therapeutic effects in critically ill patients with SARS-CoV-2.Methods: We searched four databases for randomized controlled trials (RCTs) and studies that measured macronutrient and micronutrient requirements, published from February 2020 to September 2022.Results: Ten articles reported on energy and protein requirements, and five articles reported the therapeutic effects of ω-3 (n = 1), group B vitamins (n = 1), and vitamin C (n = 3). Patients' resting energy expenditure gradually increased with time, measuring approximately 20 kcal/kg body weight (BW), 25 kcal/kg BW, and 30 kcal/kg BW for the first, second, and third week onwards, respectively. Patients remained in negative nitrogen balances in the first week, and a protein intake of ≥1.5 g/kg BW may be necessary to achieve nitrogen equilibrium. Preliminary evidence suggests that ω-3 fatty acids may protect against renal and respiratory impairments. The therapeutic effects of group B vitamins and vitamin C cannot be ascertained, although intravenous vitamin C appears promising in reducing mortality and inflammation. Conclusion:There are no RCTs to guide the optimal dose of energy and protein in critically ill patients with SARS-CoV-2. Additional larger-scale, well-designed RCTs are needed to elucidate the therapeutic effects of ω-3, group B vitamins, and vitamin C.

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“…Many studies have shown that inflammatory status is associated with dietary patterns in patients with COVID-19 (12)(13)(14)(15)(16). Adequate intake of fruits, vegetables, olive oil, nuts, and whole grains, which are components of the Mediterranean diet, is negatively associated with inflammation in patients with COVID-19 (12,17,18).…”

Section: Introductionmentioning

confidence: 99%

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

et al. 2023

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BackgroundInflammation and cytokine storm have been reported to be the main cause of acute symptoms of coronavirus disease (COVID-19). Diet-induced inflammation may affect the condition of patients with COVID-19. Therefore, this study aimed to investigate the relationship between disease severity, inflammatory and immune system biomarkers, and the dietary inflammatory index (DII) in patients with COVID-19.MethodsThis cross-sectional study was conducted on 500 adult patients with COVID-19. Patients were divided into mild, moderate, and severe conditions based on clinical and laboratory evidence. A validated food frequency questionnaire (FFQ) was used to determine DII and energy-adjusted DII (E-DII) scores. The serum C-reactive protein (CRP) level and blood cell count were measured for all patients. Multiple linear regression was used to explore the association between DII and E-DII and CRP, blood cell counts, and hospitalization in patients with COVID-19.ResultsCoronavirus disease (COVID-19) patients with higher DII had higher consumption of fat and carbohydrate and lower intakes of protein, anti-inflammatory nutrients, garlic, caffeine, tea, onion, and fiber (P < 0.05). There was a positive association between DII and CRP (β = 1.024, P < 0.001), hospitalization (β = 1.062, P < 0.001), WBC count (β = 0.486, P < 0.009), neutrophil count (β = 0.565, P < 0.001), and neutrophil-to-lymphocyte ratio (β = 0.538, P < 0.001) and a negative association between DII and the lymphocyte count (β = −0.569, P < 0.001). There was a positive association between E-DII and hospitalization (β = 1.645, P < 0.001), WBC count (β = 0.417, P < 0.02), and neutrophil-to-lymphocyte ratio (β = 0.35, P < 0.03).ConclusionThere is a positive correlation between DII and inflammation, immune hyperactivation, and length of hospital stay in patients with COVID-19. Further longitudinal studies are necessary.

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Effects of supplementation with low-dose group B vitamins on clinical and biochemical parameters in critically ill patients with COVID-19: a randomized clinical trial

Cited by 10 publications

References 29 publications

Severe COVID-19—A Review of Suggested Mechanisms Based on the Role of Extracellular Matrix Stiffness

Severe COVID-19—A Review of Suggested Mechanisms Based on the Role of Extracellular Matrix Stiffness

Macronutrient and micronutrient requirements and therapeutic effects in critically ill patients with SARS‐CoV‐2: A narrative review

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

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