A complete mass transfer model was established for an internal loop airlift reactor. All sections of the reactor, including bottom, riser, top, and downcomer, were taken into account. A numerical method was developed to solve the mass transfer model. The effectiveness of the model was validated by experimental measurements. Based on numerical results of the model, the dynamical mass transfer process in the reactor was analyzed in detail. Some mass transfer characteristics of the airlift reactor were revealed. The results indicated that the proposed model well predicted the mass transfer in the internal loop airlift reactor.A proper model for an ILALR should take all different regions of the reactor into account. As illustrated in Fig. 1 a, a typical ILALR can be divided into four sections: riser, downcomer, top