Effects of Surface Properties of Montmorillonite for their Cytocompatibility

Abstract

We modified the surface of organically modified montmorillonite (OMMT) with the carboxyl group using the silane coupling reaction and assessed its characteristics and cytocompatibility. Scanning electron microscope observations show that while the size and morphology of the obtained OMMT (OMMT-COOH) was unchanged, the surface of OMMT-COOH was coarser than that of OMMT. Fourier transform infrared spectra showed characteristic strong peaks at 1210 and 1630 cm−1, corresponding to the peaks of the carboxyl group. X-ray diffraction analysis showed that the diffraction peak of OMMT-COOH corresponding to the (001) reflection was located at higher a 2θ value than that of OMMT. Results of the proliferation ratio and cell viability measurements indicated that the OMMT-COOH cytocompatibility is higher than that of OMMT. Based on these results, we conclude that cytocompatibility of montmorillonite would be improved by tuning the properties of the surface.

Controlled Drug Release Property of Nano-Porous Silica Micro Particles and their Cytocompatibility

“…Gulati et al, reported that titania nanotubes indicated excellent molecule-load and release behavior when their internal structures were prepared [8]. We also investigated in the possibility of nano-porous silica nanoparticles for controlled drug-release system [9,10]. Based on the viewpoint of dental fields, many researchers has been interested in sustainably release materials of calsium and fluorine ions because the sustainable release of fluorine is expect to reduce the incidence of caries due to fluorapatite formation and remineralization [11][12][13].…”