Abstract-The guarantee of multiple-use water systems is one of the main objectives of Brazilian water resource management. However, the role of hydropower plants is still unclear in the achievement of these objectives. This paper introduces a method to support hydropower plants taking into account the compatibility with multiple-use water systems It also introduces a computational tool based on the proposed method, which assesses energy generation and possible losses associated with meeting upstream water demands. A case study of the Tocantins and Araguaia basins of the Amazon region is presented. The results obtained corroborate the applicability of the proposed method.