Effects of surfactant micelles on solubilization and DPPH radical scavenging activity of Rutin

Chat, Oyais Ahmad; Najar, Muzaffar Hussain; Mir, Mohammad Amin; Rather, Ghulam Mohammad; Dar, Aijaz Ahmad

doi:10.1016/j.jcis.2010.11.044

Cited by 71 publications

(59 citation statements)

References 53 publications

(89 reference statements)

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“…DPPH radical scavenging assay was done according to a published method [12]. Briefly, two milliliters of DPPH solution (0.2 mmol/L in ethanol) was incubated with different concentrations of the extract, BHT (butylated hydroxytoluene).…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

Extraction and Antioxidant Activity of Phenolic Compounds from <i>Okra</i> Flowers

Geng¹,

Liu²,

Ma³

et al. 2015

Trop. J. Pharm Res

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Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

Extraction and Antioxidant Activity of Phenolic Compounds from <i>Okra</i> Flowers

Geng¹,

Liu²,

Ma³

et al. 2015

Trop. J. Pharm Res

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“…11,18,19 The radical scavenging and the inhibition of linoleic acid oxidation has [20][21][22] Antioxidant activity seems to be strongly related to the chemical structure of the antioxidant agent and the environment (SDS or HDTBr micelles). Regarding the structure, conjugation seems to improve the antioxidant effect.…”

Section: Inhibitory Effects Of Phenolic Compoundsmentioning

confidence: 99%

Kinetic Study of the Inhibition of Linoleic Acid Oxidation in Aqueous Media by Phenolic Compounds

et al. 2011

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The antioxidant activity of several phenolic compounds has been evaluated in terms of the inhibition of the lipid oxidation. The extent of linoleic acid oxidation was monitored by the absorption of the conjugated diene hydroperoxydes formed as a result of oxidation. The antioxidant activity of phenolic compounds was evaluated in aqueous media consisting of negatively-charged micelles of sodium dodecyl sulfate (SDS) or positively-charged micelles of hexadecyl trimethylammonium bromide (HDTBr). 2,2′-azobis-(2-amidinopropane)-dihydrochloride (ABAP) was employed as the oxidation initiator. The assayed phenolic compounds showed good antioxidant efficiency, closely related to the presence of hydroxyl groups and the electron delocalization within the structure, which may stabilize the formed phenoxyl radicals. The kinetic analysis revealed that the oxidizability of linoleic acid was 10-fold higher in SDS than in HDTBr media, which could indicate that oxidation is favoured in negatively charged SDS micelles regarding to positive HDTBr medium. Furthermore, a greater antioxidant efficiency of phenolic compounds was found in HDTBr than in SDS micelles.

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“…All of the causative factors of NEC result in H/O, oxidative stress and necrosis, so that some antioxidant factors may protect against hypoxia or support tissue defense mechanisms [20,27,28]. Several studies have shown that surfactant has antioxidant effects and reduces oxidative stress, especially in lung diseases [10,11]. …”

Section: Discussionmentioning

confidence: 99%

“…Firstly, surfactant may induce antioxidant enzymes, as described previously [11]. Alternatively, surfactant may scavenge oxygen radicals, resulting in reduced MDA levels [10]. …”

Section: Discussionmentioning

confidence: 99%

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Effects of Enterally Administered Surfactant in a Rat Model of Necrotizing Enterocolitis

Canpolat

Yurdakök²,

Ersin³

2012

Neonatology

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Background: Despite technical and scientific improvements in neonatal medicine, there is still no efficient treatment for or prevention of neonatal necrotizing enterocolitis (NEC). Objective: The aim of this study was to determine the protective effect of surfactant on intestinal cells in hypoxia-induced experimental NEC in rats. Methods: The study was performed on Sprague Dawley rat pups divided into three groups. Group 1 served as nonhypoxic controls (n = 15). Group 2 rats (untreated; n = 15) were subjected to hypoxia and reoxygenation (H/O). Group 3 rats (surfactant treated; n = 15) were treated with surfactant (Curosurf; 400 mg/kg enterally) for 5 days and then subjected to H/O. All animals were killed on day 5, and histological and biochemical examinations were performed on intestinal samples. Results: There were no histopathological changes in the control group. The histological findings in untreated rats were similar to those seen in neonatal NEC, with destruction of villi and crypts and extension to the muscularis layer. The mean histological grade of group 1 was 0.2 (range 0–1), and in group 2, it was 2.1 (range 1–3). There was no statistical difference between the histological grades of groups 2 and 3 (p > 0.05). However, there was a difference between the groups that did and did not receive surfactant with regard to superoxide dismutase (SOD), glutathione peroxidase (GSH) and malondialdehyde (MDA). Conclusion: Although surfactant did not have a protective effect on histological changes in hypoxic neonatal rat intestine, it improves biochemical markers such as SOD and GSH and reduces MDA levels.

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Effects of surfactant micelles on solubilization and DPPH radical scavenging activity of Rutin

Cited by 71 publications

References 53 publications

Extraction and Antioxidant Activity of Phenolic Compounds from <i>Okra</i> Flowers

Extraction and Antioxidant Activity of Phenolic Compounds from <i>Okra</i> Flowers

Kinetic Study of the Inhibition of Linoleic Acid Oxidation in Aqueous Media by Phenolic Compounds

Effects of Enterally Administered Surfactant in a Rat Model of Necrotizing Enterocolitis

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