Effects of synbiotic supplementation as an antibiotic growth promoter replacement on cecal Campylobacter jejuni load in broilers challenged with C. jejuni

Cason, E.E.; Hakeem, Walid Ghazi Al; Adams, Daniel; Shanmugasundaram, R.; Selvaraj, Ramesh K.

doi:10.1016/j.japr.2022.100315

Cited by 7 publications

(5 citation statements)

References 69 publications

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“…In our study, the challenge model induced subclinical NE, as challenge groups had no mortality. At D14 of age (before the challenge), synbiotic did not improve the BW gain, feed intake, and FCR, and a similar result was observed by Cason et al (2023) . At D35 of age, the NE challenge significantly decreased the BW and increased the FCR compared to nonchallenged treatment groups.…”

Section: Discussionsupporting

confidence: 64%

Effect of synbiotic supplementation on production performance and severity of necrotic enteritis in broilers during an experimental necrotic enteritis challenge

et al. 2023

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Section: Discussionsupporting

confidence: 64%

Effect of synbiotic supplementation on production performance and severity of necrotic enteritis in broilers during an experimental necrotic enteritis challenge

et al. 2023

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“…C. jejuni is accepted to be a part of the commensal bacteria of the chicken gut. However, several experiments described the effects of C. jejuni infection on gut permeability, organ invasion, and proinflammatory cytokine responses, which portray it as an enteric pathogen in the chicken gut [ 84 , 85 ]. In humans, Campylobacter jejuni is the leading pathogen responsible for food poisoning in Europe and second in the US after the Salmonella species [ 86 , 87 ].…”

Section: Campylobacter Jejuni Modulation Of the Avian Gutmentioning

confidence: 99%

The Development of Gut Microbiota and Its Changes Following C. jejuni Infection in Broilers

2023

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The gut is home to more than millions of bacterial species. The gut bacteria coexist with the host in a symbiotic relationship that can influence the host’s metabolism, nutrition, and physiology and even module various immune functions. The commensal gut microbiota plays a crucial role in shaping the immune response and provides a continuous stimulus to maintain an activated immune system. The recent advancements in high throughput omics technologies have improved our understanding of the role of commensal bacteria in developing the immune system in chickens. Chicken meat continues to be one of the most consumed sources of protein worldwide, with the demand expected to increase significantly by the year 2050. Yet, chickens are a significant reservoir for human foodborne pathogens such as Campylobacter jejuni. Understanding the interaction between the commensal bacteria and C. jejuni is essential in developing novel technologies to decrease C. jejuni load in broilers. This review aims to provide current knowledge of gut microbiota development and its interaction with the immune system in broilers. Additionally, the effect of C. jejuni infection on the gut microbiota is addressed.

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“…Subsequently, the optical density of the bacterial suspension was adjusted at an OD value of 0.2, as measured at 540 nm using a spec-20. The measured OD value of 0.2 corresponded to 1 × 10 8 CFU/mL of C. jejuni [28]. This equivalence was further confirmed through serial dilution and plating on Campy-CEFEX plates.…”

Section: Jejuni Challenge Preparationmentioning

confidence: 57%

Characterizing the Effect of Campylobacter jejuni Challenge on Growth Performance, Cecal Microbiota, and Cecal Short-Chain Fatty Acid Concentrations in Broilers

Al Hakeem,

Cason,

Adams

et al. 2024

Animals

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This study aimed to understand the effect of C. jejuni challenge on the cecal microbiota and short-chain fatty acid (SCFA) concentration to form a better understanding of the host–pathogen interaction. Sixty broilers were randomly allocated into two treatments: control and challenge. Each treatment was replicated in six pens with five birds per pen. On day 21, birds in the challenge group were orally gavaged with 1 × 108C. jejuni/mL, while the control group was mock challenged with PBS. The C. jejuni challenge had no effect on body weight, feed intake, and feed conversion ratio compared to the control group. On day 28, the C. jejuni challenge decreased the observed features and Shannon index compared to the control group. On the species level, the C. jejuni challenge decreased (p = 0.02) the relative abundance of Sellimonas intestinalis on day 28 and increased (p = 0.04) the relative abundance of Faecalibacterium sp002160895 on day 35 compared to the control group. The C. jejuni challenge did not change the microbial function and the cecal concentrations of SCFA on days 28 and 35 compared to the control group. In conclusion, C. jejuni might alter the gut microbiota’s composition and diversity without significantly compromising broilers’ growth.

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Effects of synbiotic supplementation as an antibiotic growth promoter replacement on cecal Campylobacter jejuni load in broilers challenged with C. jejuni

Cited by 7 publications

References 69 publications

Effect of synbiotic supplementation on production performance and severity of necrotic enteritis in broilers during an experimental necrotic enteritis challenge

Effect of synbiotic supplementation on production performance and severity of necrotic enteritis in broilers during an experimental necrotic enteritis challenge

The Development of Gut Microbiota and Its Changes Following C. jejuni Infection in Broilers

Characterizing the Effect of Campylobacter jejuni Challenge on Growth Performance, Cecal Microbiota, and Cecal Short-Chain Fatty Acid Concentrations in Broilers

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