Effects of Synthetic Luteinizing Hormone-Releasing Hormone on Plasma Levels of Luteinizing Hormone and Follicle-Stimulating Hormone in Man

Abe, Kaoru; Nagata, Noriko; Saito, Shiro; Tanaka, Koshi; Kaneko, Takeshi; Shimizu, Naokata; Yanaihara, Noboru

doi:10.1507/endocrj1954.19.77

Cited by 19 publications

(2 citation statements)

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“…The decline in serum TSH after saline during the 90 min preceding the administration of TRH was of the same degree as that observed by others during the morning hours and interpreted as the settling of the nocturnal elevation of TSH secretion (14) that reaches a nadir around 11.00 h (15). Thus, GnRH administration did not seem to affect the serum TSH level, which is in accordance with the absence of a GnRH effect on TSH secretion alone (16), or in combination with TRH (17)(18)(19).…”

Section: Discussionsupporting

confidence: 77%

The blunting of the thyrotropin response to repeated thyrotropin-releasing hormone administration is reduced by dopaminergic blockade both at normal and elevated serum levels of thyroid hormones

Erfurth

Attewell²,

Hedner³

1990

Acta Endocrinologica

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Abstract. Fifteen premenopausal women were investigated in the follicular phase of the menstrual cycle with two TRH tests within an interval of 48 to 96 h. Ninety min before each TRH test either 10 mg metoclopramide or saline was injected iv in randomized order. The same procedure was repeated in the following menstrual cycle after pretreatment with T4 (0.5 mg daily for 6-14 days). At least 2 months later the same procedure was repeated with T3 pretreatment (60-120 μg for 6-8 days) in 9 of them. A multiple regression analysis was used in modelling the relationships between TSH release and serum free T3, T4 and estradiol levels, adjusting for the presence of metoclopramide and the order of the test. No correlation was found between the TSH response to TRH and the serum estradiol level. The TSH response to the second TRH test was approximately half the first one, both in the control situation and after treatment with T4 or T3. The blunting of the TSH response to the second TRH administration was significantly reduced by metoclopramide, both at normal and elevated thyroid hormone levels, suggesting that a dopaminergic mechanism takes part in the blunting.

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Section: Discussionsupporting

confidence: 77%

The blunting of the thyrotropin response to repeated thyrotropin-releasing hormone administration is reduced by dopaminergic blockade both at normal and elevated serum levels of thyroid hormones

Erfurth

Attewell²,

Hedner³

1990

Acta Endocrinologica

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“…Luteinizing hormone-releasing hormone (Schally et al, 1971;Matsuo et al, 1971), has been available for the study of pituitary gonadotropin reserve (Abe et al, 1972;Naftolin et al, 1971;Yen et al, 1972;Roth et al, 1972;Job et al, 1972;Yoshimoto et al, 1975). Administration of this synthetic LH-RH to normal individuals causes release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (Yen et al, 1972;Roth et al, 1972), but does not cause release of growth hormone (GH) (Abe et al, 1972;Wagner et al, 1972). We gave LH-RH to two patients with hypogonadotropic hypogonadism to differ- After a series of endocrinologic examination and testicular biopsy, he was treated with hCG intramuscularly, 5000 IU twice weekly, for 14 months.…”

mentioning

confidence: 99%

Stimulation of growth hormone release by luteinizing hormone-releasing hormone in two males with isolated gonadotropin deficiency.

et al. 1976

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The pituitary functions were tested in two males with the typical clinical pictures of hypogonadism. The secretions of ACTH, TSH, GH and prolactin in these patients were maintained within normal limits, whereas they had markedly diminished LH and FSH levels in plasma. Plasma LH and FSH responses to the intravenous injection of 100 mug LH-RH were absent or limited. After 7-day treatment with intravenous infusion of 400 mug LH-RH, they showed normal or improved responses to the intravenous injection of 100 mug LH-RH. Thus, the diagnosis of isolated gonadotropin deficiency due to a hypothalamic lesion was established. Initially, the standard LH-RH test (100 mug intravenous injection) did not elicit a rise in plasma GH levels. However, it was of interest that after the repeated stimulation by 400 mug LH-RH, GH response to the intravenous injection of 100 mug LH-RH was observed in both patients.

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Hypothalamic hypophysiotropic hormones

Fleischer

Guillemin

1976

Peptide Hormones

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Effects of Synthetic Luteinizing Hormone-Releasing Hormone on Plasma Levels of Luteinizing Hormone and Follicle-Stimulating Hormone in Man

Cited by 19 publications

References 6 publications

The blunting of the thyrotropin response to repeated thyrotropin-releasing hormone administration is reduced by dopaminergic blockade both at normal and elevated serum levels of thyroid hormones

The blunting of the thyrotropin response to repeated thyrotropin-releasing hormone administration is reduced by dopaminergic blockade both at normal and elevated serum levels of thyroid hormones

Stimulation of growth hormone release by luteinizing hormone-releasing hormone in two males with isolated gonadotropin deficiency.

Hypothalamic hypophysiotropic hormones

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