Effects of systemic injection of neuroleptics on neuronal background activity in the cat ventrolateral thalamic nucleus

Lukhanina, E. P.

doi:10.1007/bf01052882

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…This would restore the release of GABA to specific thalamic nuclei. As a result, chronic administration of antipsychotic drugs would increase the level of inhibition in specific thalamic nuclei, which was indeed demonstrated for haloperidol (Lukhanina 1989). Clozapine, which is known to be particularly effective in the treatment of symptoms of schizophrenia, is characterised by a high affinity for the D4 receptor.…”

Section: Dopaminergic Hyperactivitymentioning

confidence: 85%

Hallucinations in schizophrenia, sensory impairment, and brain disease: A unifying model

Behrendt

Young²

2004

Behav Brain Sci

120

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Based on recent insight into the thalamocortical system and its role in perception and conscious experience, a unified pathophysiological framework for hallucinations in neurological and psychiatric conditions is proposed, which integrates previously unrelated neurobiological and psychological findings. Gamma-frequency rhythms of discharge activity from thalamic and cortical neurons are facilitated by cholinergic arousal and resonate in networks of thalamocortical circuits, thereby transiently forming assemblies of coherent gamma oscillations under constraints of afferent sensory input and prefrontal attentional mechanisms. If perception is based on synchronisation of intrinsic gamma activity in the thalamocortical system, then sensory input to specific thalamic nuclei may merely play a constraining role. Hallucinations can be regarded as underconstrained perceptions that arise when the impact of sensory input on activation of thalamocortical circuits and synchronisation of thalamocortical gamma activity is reduced. In conditions that are accompanied by hallucinations, factors such as cortical hyperexcitability, cortical attentional mechanisms, hyperarousal, increased noise in specific thalamic nuclei, and random sensory input to specific thalamic nuclei may, to a varying degree, contribute to underconstrained activation of thalamocortical circuits. The reticular thalamic nucleus plays an important role in suppressing random activity of relay cells in specific thalamic nuclei, and its dysfunction may be implicated in the biological vulnerability to hallucinations in schizophrenia. Combined with general activation during cholinergic arousal, this leads to excessive disinhibition in specific thalamic nuclei, which may allow cortical attentional mechanisms to recruit thalamic relay cells into resonant assemblies of gamma oscillations, regardless of their actual sensory input, thereby producing an underconstrained perceptual experience.

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Section: Dopaminergic Hyperactivitymentioning

confidence: 85%

Hallucinations in schizophrenia, sensory impairment, and brain disease: A unifying model

Behrendt

Young²

2004

Behav Brain Sci

120

View full text Add to dashboard Cite

show abstract

“…D2 and D4 are metabotropic receptors that are negatively coupled to adenylate cyclase, and their activation on reticular thalamic neurons -among other effects -may suppress activation or expression of glutamic acid decarboxylase, which is the rate-limiting enzyme in the synthesis of GABA. As a result, chronic administration of antipsychotic drugs would increase the level of inhibition in specific thalamic nuclei, which was indeed demonstrated for haloperidol (Lukhanina 1989). D2 and D4 receptors are common targets for antipsychotic drugs.…”

Section: Dopaminergic Hyperactivitymentioning

confidence: 71%

Gamma rhythms as liminal operators in sensory processing

Whittington

2004

Behav Brain Sci

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Effects of systemic injection of neuroleptics on neuronal background activity in the cat ventrolateral thalamic nucleus

Cited by 2 publications

References 15 publications

Hallucinations in schizophrenia, sensory impairment, and brain disease: A unifying model

Hallucinations in schizophrenia, sensory impairment, and brain disease: A unifying model

Gamma rhythms as liminal operators in sensory processing

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