Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies

Abstract

PROSPERO (CRD42017078208).

Do analgesics used for the pain experienced after orthodontic procedures affect tooth movement rate? A systematic review based on animal studies

“…Regarding the latter, root resorption was shown to decrease after administering ibuprofen and meloxicam in low doses. However, no difference was noted in the cases of paracetamol and aspirin . The other review presented information on the administration of analgesics for a duration of more than 2 weeks, which is not consistent with the usual clinical practice in case of pain experienced due to orthodontic procedures.…”

“…Recently, systematic reviews have elaborated on the potential effects of medication used for the relief of pain on orthodontic tooth movement and associated root resorption in experimental animals . Regarding the latter, root resorption was shown to decrease after administering ibuprofen and meloxicam in low doses.…”

Pharmaka, Noxen und die Ernährung – welche anamnestische Relevanz haben sie für die kieferorthopädische Therapie?

“…Unselektive NSAID sollten daher während einer kieferorthopädischen Therapie nach Möglichkeit nicht eingesetzt werden. In Studien zeigte sich jedoch als interessanter Nebeneffekt eine signifikante Reduktion therapieassoziierter Zahnwurzelresorptionen unter Einfluss von NSAID, welcher in Zukunft einen Ansatz für eine gezielte pharmakologische Prävention von Zahnwurzelresorptionen in speziellen Fällen darstellen könnte [5,6]. Können Antibiotika unerwünschte Nebenwirkungen im Rahmen einer kieferorthopädischen Therapie entfalten?…”

Local delivery of simvastatin maintains tooth anchorage during mechanical tooth moving via anti‐inflammation property and AMPK/MAPK/NF‐kB inhibition

“…According to clinical trials observation, SMV intake was beneficial for chronic periodontitis control for its function in inflammation limitation and periodontal tissues repair 9‐11 . Animal studies have shown that SMV when administered systemically resulted in increased tooth anchorage and reduced root resorption 3,12 . To be mentioned, the pocket injection of 1.2% SMV gel decreased space re‐opening after orthodontic space closure in human anterior teeth 13 .…”

“…[9][10][11] Animal studies have shown that SMV when administered systemically resulted in increased tooth anchorage and reduced root resorption. 3,12 To be mentioned, the pocket injection of 1.2% SMV gel decreased space re-opening after orthodontic space closure in human anterior teeth. 13 We thus assume a bone anabolic property of SMV on periodontal tissue under a biomechanically induced inflammatory condition.…”