Effects of Tadalafil 5 mg Dosed Once Daily in Men with Premature Ejaculation

Abstract

Purpose: In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejaculation (PE). Methods: Thirty married men with lifelong PE and 30 healthy men as control group were included in this study. All the patients received 5 mg tadalafil once a day for a month. The international index of erectile function questionnaire and intravaginal ejaculatory latency times (IELTs) and PE profile were recorded before and after treatment. Plasma samples were collected before and after treatment. Results: The mean baseline IELTs was 40.8 ± 8.1 s in the PE group and 196.5 ± 26.2 s in the control group. After treatment in the PE group, the mean IELTs values showed a statistically significant improvement from the baseline values. At the end of 4 weeks, in the PE group, the mean IELT values showed a statistically significant improvement from the baseline values. Baseline serum nitric oxide (NO) levels were 27.3 ± 1.7 in the PE group and in the 31.1 ± 1.4 healthy control groups. After treatment, NO levels were increased from baseline. Conclusion: We consider that 5 mg tadalafil once daily is safety and effective for the treatment of PE.

Efficacy and safety of daily use of tadalafil in treatment of patients with premature ejaculation: A randomised placebo‐controlled clinical trial

“…This finding was in agreement with Ozcan et al. (), who found that administration of 5 mg tadalafil once daily for 1 month was safe in the treatment of patients with lifelong PE and the most common side effects were headache, back pain, myalgia, dyspepsia and gastroesophageal reflux. Dell'Atti et al.…”

“…This finding was in agreement with Ozcan et al. (), who reported that administration of 5 mg tadalafil once daily for 1 month was effective in the treatment of patients with lifelong PE as it improved IELT and premature ejaculation profile. Karabakan, Keskin, Akdemir, and Bozkurt () found that administration of 5 mg tadalafil once daily for 3 months showed a significant increase in IELT and IIEF‐5 values of patients with ED and PE.…”

Effect of tadalafil 5mg daily treatment on the ejaculatory times, lower urinary tract symptoms and erectile function in patients with erectile dysfunction

“…PDE5 inhibitors are frequently used in the treatment of ED and clinical studies have reported their positive effect on patients with PE ( 14 - 16 ). In a recent study, a daily dose of 5mg tadalafil has been shown to significantly increase IELT in patients diagnosed with lifelong PE ( 17 ). However, to our knowledge, there is no study in the literature that determined the effect of tadalafil 5mg daily on ejaculatory time in patients with ED.…”

Combination or alone ? Which one is best in premature ejaculation treatment?

“…For example, in a study carried out by Özcan et al, it was determined that single-dose 5 mg tadalafil usage in males with premature ejaculation provides a significant increase in IELT by developing the ejaculation control perception, increasing sexual satisfaction, and being beneficial on the personal stress related to ejaculation. However, as noted by the authors, the role of PDE 5 inhibitors in premature ejaculation is controversial [16] .…”