Effects of taking tadalafil 5 mg once daily on erectile function and total testosterone levels in patients with metabolic syndrome

Abstract

We aimed to evaluate the efficacy of tadalafil 5 mg once-daily treatment on testosterone levels in patients with erectile dysfunction (ED) accompanied by the metabolic syndrome. A total of 40 men with metabolic syndrome were evaluated for ED in this study. All the patients received 5 mg tadalafil once a day for 3 months. Erectile function was assessed using the five-item version of the International Index of Erectile Function (IIEF) questionnaire. Serum testosterone, follicle-stimulating hormone and luteinising hormone levels were also evaluated, and blood samples were taken between 08.00 and 10.00 in the fasting state. All participants have three or more criteria of metabolic syndrome. At the end of 3 months, mean testosterone values and IIEF scores showed an improvement from baseline values (from 3.6 ± 0.5 to 5.2 ± 0.3, from 11.3 ± 1.9 to 19 ± 0.8 respectively). After the treatment, serum LH levels were decreased (from 5.6 ± 0.6 to 4.6 ± 0.5). There was significantly difference in terms of baseline testosterone and luteinising hormone values and IIEF scores (p < .05). Based on our findings, we recommend tadalafil 5 mg once daily in those men with erectile dysfunction especially low testosterone levels accompanied by metabolic syndrome.

Effect of tadalafil on chronic pelvic pain and prostatic inflammation in a rat model of experimental autoimmune prostatitis

“…Another possibility is related to the fact that testosterone has an anti‐inflammatory effect in metabolic‐syndrome‐associated prostate inflammation . Several clinical reports have noted increased levels of testosterone after administration of tadalafil 5 mg once daily for three months . In our study, however, there was no clear increase in the testosterone/estradiol ratio, so it is unlikely that testosterone contributed to anti‐inflammatory effects.…”

Correcting imbalance of sex hormones by a phosphodiesterase 5 inhibitor improves copulatory dysfunction in male rats with type 2 diabetes

“…26 Furthermore, 3-month treatment with tadalafil 5 mg once daily increased serum testosterone levels and was effective for ED in men caused by low testosterone levels due to metabolic syndrome. 27 Therefore, tadalafil itself does not improve the copulatory disorder or increase sexual desire, but rather increases testosterone levels, which leads to improved copulatory function in the present study. As a result, it is possible that tadalafil treatment may prevent sexual activity from worsening in men with type 2 diabetes.…”

Should All Men with Type 2 Diabetes Be Routinely Prescribed a Phosphodiesterase Type 5 Inhibitor?

“…Hellstrom et al [34], in a placebo-controlled study designed to assess sperm parameters in 253 men treated with tadalafil 20 mg for 3 months found significant increases in total testosterone vs. placebo and no significant effect on semen parameters over 3 cycles. Ozcan et al [35] treated 40 men with metabolic syndrome with tadalafil 5mg for 3 months with an increase of testosterone from 11.4 (baseline) to 16.5 nmol/ L, and IIEF-5 from 11.3 to 19. The authors recommend tadalafil 5 mg once daily in those men with ED especially low testosterone levels accompanied by metabolic syndrome.…”