Effects of tamoxifen, medroxyprogesterone acetate, and their combination on human endometrial estrogen and progestin receptor concentrations, 17β-hydroxysteroid dehydrogenase activity, and serum hormone concentrations

Kokko, E.; Jänne, Olli A.; Kauppila, Antti; Vihko, R.

doi:10.1016/0002-9378(82)90077-1

Cited by 34 publications

(15 citation statements)

References 12 publications

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“…Animal experimental models with tamoxifen suggest a differential cell stimulation with extensive hypertrophy of epithelial endometrial elements and only partial stimulation of stromal and myometrial elements (Clark & Peck 1979). This pattern of response is supported by clinical experience since some women on tamoxifen have regular periods (Kokko et al 1982; Cano et al 1989).…”

Section: Discussionmentioning

confidence: 75%

“…There are at least four important nongenomic regulatory systems in the endometrial cell on which tamoxifen also exerts metabolic effects: the protein kinase C, the calmodulin system, steroid hormone receptors and the beta–hydroxy steroid dehydrogenase. (Kokko et al 1982; Weiss & Gurpide 1988; Corley et al 1992). These extra‐genomic effects on endometrial cell function are demonstrable in vitro but not yet in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…We now know that cytosolic oestrogen receptor was artifactual. Indeed, oestrogen receptor occupied or unoccupied is an entirely nuclear bound protein (Kokko et al 1982; King & Greene 1984; Welshons 1984; Muldoon 1985; Walters 1985; Gorski et al 1986). Steroid hormone receptors are synthesised in the cytoplasm but are quickly transported into the nucleus.…”

Section: Discussionmentioning

confidence: 99%

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Tamoxifen induced adenomyosis and adenomyomatous endometrial polyp

Ugwumadu

Bower²,

Ho³

1993

BJOG

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Tamoxifen induced adenomyosis and adenomyomatous endometrial polyp

Ugwumadu

Bower²,

Ho³

1993

BJOG

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“…The effects of long-term and short-term progestin treatments on human endome trium have been investigated previously; whereas the former cause atrophic changes, the latter result in cellular activity as evi denced by various histological and biochemi cal parameters [1,8],…”

Section: Discussionmentioning

confidence: 99%

Effect of Single-Dose Progesterone Administration on Estradiol Receptor Levels in Normal Human Endometrium

Gorodeski

Bahari

Beery

et al. 1985

Gynecol Obstet Invest

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The effects of single-dose progesterone administration on cytosolic and nuclear estradiol receptor levels (R_CE₂, R_NE₂) in normal human endometrium were studied in a group of 17 women and the results compared to 18 controls. In both groups, R_CE₂ and R_NE₂ levels were highest in the mid-cycle phase and lowest in the secretory phase. Although a wide range of values was found in both groups, the levels of R_CE₂ in the two groups did not differ significantly. It seems that in human endometrium a single progesterone injection does not significantly change R_CE₂ and R_NE₂ levels.

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“…The continuous progesterone action appears to be the result of estrogenic modulation of this action resulting in decidualization. The balance between the two can be distorted by disturbing either of the hormones or the two receptor systems (estrogen and progesterone) (5). Triphenylethylene derivatives like clomiphene and tamoxifen are reported to inhibit the decidual cell response at the time of induction treatment by inhibition of at least one of the actions of estrogen in the uterus (6).…”

Section: Introductionmentioning

confidence: 99%

Changes in uterine ornithine decarboxylase activity and steroid receptor levels during decidualization in the rat induced by CDRI-85/287

Dwivedi

Gupta

Keshri³

et al. 1999

European Journal of Endocrinology

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CDRI-85/287 is an anti-estrogen and interferes with decidualization in the rat uterus. In this study, uterine estrogen receptor (ER) and progesterone receptor (PR) levels were determined during the inhibition of decidualization. The effect of 85/287 on uterine ornithine decarboxylate (ODC) activity (a marker enzyme for decidualization) was also studied, using immature ovariectomized rats divided into four different groups: control, 2.5 mg/kg 85/287 only; 1 mg estradiol only; and 85/287 þ estradiol. Pseudopregnant rats were administered 85/287 (2.5 mg/kg p.o.) on day 3 post-coitum. Deciduoma was induced in one of the uterine horns on day 4 and animals were autopsied 18 h post-traumatization. Both ERs and PRs showed an increase in traumatized horns compared with non-traumatized. In the 85/287-treated uterus, there was a reduction in cytosolic ERs in both traumatized horns. However, nuclear ER and PR levels increased in both horns under the influence of 85/287. Similarly, in a tamoxifen (0.03 mg/kg)-treated group a decline was noticed in cytosolic ER with a mild increase in nuclear PR. Total ER content, expressed per 100 mg DNA, showed a decline in 85/287-or tamoxifentreated rats. However, no significant alterations were observed in total PR levels in non-traumatized horns. In an immature rat model, 85/287 caused a significant (> 50%) reduction in estradiol-induced ODC activity. These findings suggest that the decidualization inhibitory activity of 85/287 may be attributed to inhibition of certain timed biochemical events and genomic/non-genomic actions of estrogens in the rat uterus.

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Effects of tamoxifen, medroxyprogesterone acetate, and their combination on human endometrial estrogen and progestin receptor concentrations, 17β-hydroxysteroid dehydrogenase activity, and serum hormone concentrations

Cited by 34 publications

References 12 publications

Tamoxifen induced adenomyosis and adenomyomatous endometrial polyp

Tamoxifen induced adenomyosis and adenomyomatous endometrial polyp

Effect of Single-Dose Progesterone Administration on Estradiol Receptor Levels in Normal Human Endometrium

Changes in uterine ornithine decarboxylase activity and steroid receptor levels during decidualization in the rat induced by CDRI-85/287

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