Effects of Taurine on Broiler Aortic Endothelial Apoptosis Induced by Heat Stress

Cui, Yiqing; Wu, Guanghui; Wang, Zhenyong; Huang, Fan; ZhiLi, Ning; Chu, Ling; Yang, Sibo; Lv, Qiufeng; Hu, Jianmin

doi:10.1007/978-981-13-8023-5_37

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…TAU prevented apoptosis in traumatic brain injury by decreasing Bax, caspase‐3 and p53 expression (Niu et al., 2018). TAU diminished the expression of Bax, caspase‐9 and caspase‐3 in broiler aortic endothelial cells against heat shock (Cui et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Taurine ameliorates cytotoxic effects of Di(2‐ethylhexyl) phthalate on Leydig cells

et al. 2021

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It has been revealed that di(2‐ethylhexyl)phthalate (DEHP) has toxic impacts on the male reproductive system. Taurine (TAU) is an amino acid with antioxidant property and beneficial impacts on the male reproductive system. In this study, protective impacts of Taurine (TAU) on DEHP‐induced Leydig TM3 cell toxicity were investigated. The cells exposed to DEHP (0.8 µmol) or TAU (100 mg/ml) for 24 hr. Cell viability (MTT assay), apoptosis, oxidative stress and testosterone level were examined. DEHP could significantly decrease the cell viability percentage, reduce testosterone level, increase apoptosis, elevate Bax/ Bcl‐2 ratio and enhance caspase‐3 and ‐9 activity in the TM3 cells. Additionally, DEHP significantly elevated malondialdehyde contents and reactive oxygen species levels. It also augmented superoxide dismutase and catalase activity in the Leydig cells. Co‐treatment of DEHP with TAU increased viability and testosterone level, while oxidative stress and apoptosis significantly reduced. TAU could decrease Bax/Bcl‐2 ratio and caspase‐3 and ‐9 activity in the DEHP‐intoxicated cells. Our results have clearly shown that TAU protects TM3 cells against oxidative stress and apoptosis induced by DEHP.

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Section: Discussionmentioning

confidence: 99%

Taurine ameliorates cytotoxic effects of Di(2‐ethylhexyl) phthalate on Leydig cells

et al. 2021

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“…Extensive research has shown that taurine improves antioxidant levels, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), as well as catalase (CAT) [ 14 , 15 ]. Previous studies have also focused on the importance of taurine in terms of its anti-apoptosis effect, with one study indicating taurine markedly hampered increases in the expression of Bax, Caspase9, Caspase3, Cytochrome c (Cyt-c) and P53 in broiler aortic endothelial cells under heat shock [ 16 ]. Furthermore, the taurine additive has been reported to have anti-inflammatory effects [ 17 , 18 ], as well as treating intractable diseases, such as Alzheimer’s disease [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective Effects of Taurine on Heat-Induced Bovine Mammary Epithelial Cells In Vitro

Bai

et al. 2021

Cells

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It is a widely known that heat stress induces a reduction in milk production in cows and impairs their overall health. Studies have shown that taurine protects tissues and organs under heat stress. However, there have yet to be studies showing the functions of taurine in mammary alveolar cells-large T antigen (MAC-T) (a bovine mammary epithelial cell line) cells under heat shock. Therefore, different concentrations of taurine (10 mM, 50 mM, and 100 mM) were tested to determine the effects on heat-induced MAC-T cells. The results showed that taurine protected the cells against heat-induced damage as shown by morphological observations in conjunction with suppressed the translocation and expression of heat shock factor 1 (HSF1). Moreover, taurine not only reversed the decline in antioxidase (superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX)) activities but also attenuated the accumulation of malondialdehyde (MDA). Meanwhile, mitochondrial damage (morphology and complex I activity) resulting from heat exposure was mitigated. Taurine also alleviated the rates of cell apoptosis and markedly depressed the mRNA expressions of BCL2 associated X, apoptosis regulator (BAX) and caspase3. Furthermore, compared with the heat stress (HS) group, the protein levels of caspase3 and cleaved caspase3 were decreased in all taurine groups. In summary, taurine improves the antioxidant and anti-apoptosis ability of MAC-T cells thereby alleviates damage of cells due to heat insults.

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Heat stress decreases egg production of laying hens by inducing apoptosis of follicular cells via activating the FasL/Fas and TNF-α systems

Liu

Yin

et al. 2020

Poultry Science

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Effects of Taurine on Broiler Aortic Endothelial Apoptosis Induced by Heat Stress

Cited by 4 publications

References 13 publications

Taurine ameliorates cytotoxic effects of Di(2‐ethylhexyl) phthalate on Leydig cells

Taurine ameliorates cytotoxic effects of Di(2‐ethylhexyl) phthalate on Leydig cells

Cytoprotective Effects of Taurine on Heat-Induced Bovine Mammary Epithelial Cells In Vitro

Heat stress decreases egg production of laying hens by inducing apoptosis of follicular cells via activating the FasL/Fas and TNF-α systems

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