Effects of Taurine on Cerulein-Induced Acute Pancreatitis in the Rat

Ahn, Byung Ok; Kim, Kwang Hee; Lee, Goo; Lee, Hong Sik; Kim, Chang Duck; Kim, Young Sik; Son, Miwon; Kim, Won; Oh, Tae Young; Hyun, Jin Hai

doi:10.1159/000056106

Cited by 29 publications

(20 citation statements)

References 27 publications

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“…Taurine has been shown to possess significant antiinflammatory properties in various in vivo and in vitro models of inflammation [17]. In TNBS-induced inflammatory bowel disease [6] and cerulein-induced pancreatitis [7], exogenous taurine protected the tissues by increasing the defending capacity of organs against oxidative damage. Similarly, it has been reported that the protective effect of taurine against indomethacin-induced gastric mucosal injury was a direct result of its antioxidant effects which inhibited lipid peroxidation and neutrophil activation [5].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been suggested that the beneficial effect of taurine against indomethacin-induced gastric mucosal damage was due to its antioxidant effects through inhibition of lipid peroxidation and neutrophil activation [5]. In addition, exogenous taurine reduced the inflammatory responses in trinitrobenzene sulfonic acid (TNBS)-induced colitis [6] and cerulein-induced pancreatitis in rats by preventing the production of oxygen free radicals [7].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Taurine against Nicotine-Induced Oxidative Damage of Rat Urinary Bladder and Kidney

et al. 2005

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Several studies demonstrate that taurine treatment prevents tissue damage in various models of inflammation. Experiments have shown that chronic nicotine administration caused oxidant damage in various organs by increasing lipid peroxidation products and decreasing the activity of endogenous antioxidants. The aim of this study was to investigate the effects of taurine treatment on nicotine-induced oxidative changes in rat urinary bladder and kidney and to explore the possible mechanisms of action. Male Wistar albino rats were injected with nicotine hydrogen bitartrate (0.6 mg/kg i.p.) or saline for 21 days. Taurine was administered (50 mg/kg i.p.) alone or along with nicotine injections. At the end of the treatment period bladder tissue was used for in vitro contractility studies, or stored along with kidney tissue for the measurement of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen content. Tissue samples were also examined histologically. Serum samples were stored for the measurement of MDA, GSH, blood urea nitrogen, creatinine and lactate dehydrogenase activity. Chronic nicotine treatment decreased the contractile activity of the bladder strips to carbachol and increased lipid peroxidation, MPO levels and tissue collagen content of the bladder and kidney samples. Taurine supplementation to nicotine-treated animals reversed the contractile dysfunction of the bladder strips. It also preserved the renal functions, restored the endogenous GSH levels and decreased high lipid peroxidation and MPO activities in both urinary bladder and kidney tissues. These data suggest that taurine supplementation effectively counteracts the deleterious effect of chronic nicotine administration on bladder and kidney functions and attenuates oxidative damage possibly by its antioxidant effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective Effects of Taurine against Nicotine-Induced Oxidative Damage of Rat Urinary Bladder and Kidney

et al. 2005

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“…An inflammatory cascade has been implicated in the pathogenesis of acute pancreatitis (Ahn et al, 2001;Mikawa et al, 2001). TNF-␣ is detected in plasma early in the course of acute pancreatitis, and pretreatment of rats with antibodies raised against the inflammatory cytokine reduces elevated serum amylase in acute pancreatitis (Demols et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Attenuated Cerulein-Induced Pancreatitis in Nuclear Factor–κB–Deficient Mice

Altavilla

Famulari

Passaniti

et al. 2003

Laboratory Investigation

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SUMMARY:Nuclear factor (NF)-B plays a central role in acute pancreatitis. We studied cerulein (CER)-induced pancreatitis in NF-B knockout (KO) mice. NF-B KO mice and normal control littermate wild-type (WT) mice were given four hyperstimulating doses of cerulein every hour to elicit secreatagogue-induced pancreatitis. Malonildialdehyde activity, glutathione levels, myeloperoxidase activity, TNF-␣, and NF-B binding activity and its inhibitory protein IB␣ were studied in the pancreas. Furthermore, we measured plasma lipase and amylase and the histological damage. KO mice had reduced malonildialdehyde levels (WT ϩ CER ϭ 4.083 Ϯ 0.95 mol/g; KO ϩ CER ϭ 1.513 Ϯ 0.63 mol/g), decreased myeloperoxidase activity (WT ϩ CER ϭ 19.3 Ϯ 2.39 mU/g; KO ϩ CER ϭ 10.21 Ϯ 2.05 mU/g), increased glutathione levels (WT ϩ CER 6.22 Ϯ 2.46 mol/g; KO ϩ CER ϭ 15. 516 Ϯ 2.92 mol/g), and reduced serum levels of amylase (WT ϩ CER ϭ 2519 Ϯ 656.9 U/L; KO ϩ CER ϭ 916 Ϯ 280.4 U/L) and lipase (WT ϩ CER ϭ 1420 Ϯ 170 U/L; KO ϩ CER ϭ 861 Ϯ 172. 3 U/L). KO mice showed reduced pancreatic NF-B activation, decreased TNF-␣ tissue content, and reduced histologic alterations. Our data suggest that KO mice have an attenuated cerulein-induced pancreatitis and help to define the possible interaction between NF-B activation and oxidative stress in this deleterious event. (Lab Invest 2003, 83:1723-1732.

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“…It plays important roles in numerous physiological functions including conjugation with bile acids, modulation of calcium levels, and maintenance of osmolarity, antioxidation and stabilization of membranes [3] . It was reported to have beneficial effects in various physiological and pathological conditions [4][5][6][7] by mainly diminishing production of reactive oxygen species (ROS). It also can prevent DNA damage at physiological concentrations [8] .…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural changes in hepatocytes after taurine treatment in CCl4 induced liver injury

Taşçı

Mas²,

Mas³

et al. 2008

WJG

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AIM:To search the organelle based changes in hepatocytes after taurine treatment in experimental liver fibrosis induced by CCl 4 administration. METHODS: Thirty rats were divided into two groups. Group 1 (n = 15) was injected with CCl 4 plus taurine and Group 2 (n = 15) with CCl 4 plus saline for 12 wk. At the end of 12th wk, mitochondria, rough and smooth endoplasmic reticulum, and nuclei of hepatocytes were evaluated using a scoring system. The results were compared with histopathological findings, as well. RESULTS: Taurine treatment reduced fibrosis scores significantly as compared to placebo. Organelle injury scores decreased significantly with taurine treatment. Ultrastructural and histopathological scores in both groups were in strong correlation (r = 0.931 for CCl 4 plus taurine and r = 0.899 for CCl 4 plus saline group). CONCLUSION:Organelle based transmission electron microscopy findings can reflect successfully histological results as well as tissue healing in hepatocytes from hepatotoxin-induced liver fibrosis.

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Effects of Taurine on Cerulein-Induced Acute Pancreatitis in the Rat

Cited by 29 publications

References 27 publications

Protective Effects of Taurine against Nicotine-Induced Oxidative Damage of Rat Urinary Bladder and Kidney

Protective Effects of Taurine against Nicotine-Induced Oxidative Damage of Rat Urinary Bladder and Kidney

Attenuated Cerulein-Induced Pancreatitis in Nuclear Factor–κB–Deficient Mice

Ultrastructural changes in hepatocytes after taurine treatment in CCl4 induced liver injury

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