Effects of taurine on striatal dopamine transporter expression and dopamine uptake in SHR rats

Chen, Vincent Chin‐Hung; Chiu, Chen‐Yuan; Chen, Li-Jeng; Hsu, Tsai‐Ching; Tzang, Bor‐Show

doi:10.1016/j.bbr.2018.04.031

Cited by 16 publications

(16 citation statements)

References 61 publications

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“…Taurine deficiency has been shown to impair long-term plasticity in the striatum, but not in the hippocampus (Sergeeva et al, 2003). Moreover, in the rat striatum, taurine was shown to modulate dopamine uptake in a dose-dependent manner (Chen et al, 2018). Importantly, taurine supplementation can rescue GABA A -mediated disinhibition of striatal network activity in taurinetransporter knockout mice (Sergeeva et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Strasser

Xin

Gruetter

et al. 2018

Preprint

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Individual differences in anxiety provide a differential predisposition to develop neuropsychiatric disorders. The neurochemical underpinnings of anxiety remain elusive, particularly in deep structures, such as the nucleus accumbens (NAc) whose involvement in anxiety is being increasingly recognized.We examined the associations between the neurochemical profile of human NAc metabolites involved in neural excitation and inhibition and inter-individual variation in temperamental and situational anxiety. Twenty-seven healthy 20-30 years-old human males were phenotyped with questionnaires for state and trait anxiety (State-Trait Anxiety Inventory, STAI), social anxiety (Liebowitz Social Anxiety Scale), depression (Beck Depression Inventory, BDI) and fatigue (Mental and Physical State Energy and Fatigue Scales, SEF). Using proton magnetic resonance spectroscopy ( 1 H-MRS) at 7 Tesla (7T), we measured metabolite levels for glutamate, glutamine, GABA and taurine in the NAc with. Salivary cortisol was also measured. Strikingly, trait anxiety was negatively associated with NAc taurine content. Perceived situational stress was negatively associated with NAc GABA, while positively with the Glu/GABA ratio. These findings were specific, as no correlation was observed between NAc taurine or GABA and other phenotypic variables examined (i.e., state anxiety, social anxiety, depression, or cortisol), except for a negative correlation between taurine and state physical fatigue. This first 7T study of NAc neurochemistry shows relevant metabolite associations with individual variation in anxiety traits and situational stress and state anxiety measurements. The novel identified association between NAc taurine levels and trait anxiety may pave the way for clinical studies aimed at identifying new treatments for anxiety and related disorders.

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Section: Discussionmentioning

confidence: 99%

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Strasser

Xin

Gruetter

et al. 2018

Preprint

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“…The lack of this substance is one of the causes of Parkinson’s disease, an illness that affects more than 10 million people worldwide [60]. In addition, alterations in the normal levels of dopamine are associated with attention-deficit hyperactivity disorder, which affects between 2 and 7% of children, adolescents, and adults in the world [61].…”

Section: Calix[n]arenesmentioning

confidence: 99%

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

2019

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The properties and characteristics of calix[n]arenes are described, as well as their capacity to form amphiphilic assemblies by means of the design of synthetic macrocycles with a hydrophilic head and a hydrophobic tail. Their interaction with various substances of interest in pharmacy, engineering, and medicine is also described. In particular, the role of the calix[n]arenes in the detection of dopamine, the design of vesicles and liposomes employed in the manufacture of systems of controlled release drugs used in the treatment of cancer, and their role in improving the solubility of testosterone and anthelmintic drugs and the biocompatibility of biomaterials useful for the manufacture of synthetic organs is emphasized. The versatility of these macrocycles, able to vary in size, shape, functional groups, and hydrophobicity and to recognize various biomolecules and molecules with biological activity without causing cytotoxicity is highlighted.

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“…Also, Chen et al, 84 report a significantly lower dopamine uptake was detected in the striatal synaptosomes of SHR rats that were fed with highdose taurine than those of the controls. It also affects norepinephrine uptake and releases in rat cerebral cortical slices 85 .…”

Section: Discussionmentioning

confidence: 92%

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2021

IJPSR

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Effects of taurine on striatal dopamine transporter expression and dopamine uptake in SHR rats

Cited by 16 publications

References 61 publications

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

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Effects of taurine on striatal dopamine transporter expression and dopamine uptake in SHR rats

Cited by 16 publications

References 61 publications

Nucleus accumbens neurochemistry in human anxiety: A 7 T1H-MRS study

Nucleus accumbens neurochemistry in human anxiety: A 7 T1H-MRS study

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

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Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study

Nucleus accumbens neurochemistry in human anxiety: A 7 T¹H-MRS study