Effects of TCMs andLactobacillusstrains on immunosuppressed mice and bacteriostatic effect onEscherichia coliK88 after fermentation

Abstract

The aim of this study was to investigate a novel means of treating piglet diarrhoea caused by enterotoxigenic Escherichia coli (ETEC) strain K88 using traditional Chinese medicine (TCM) fermented by selected probiotic strains. Six types of TCMs were determined to be efficient at inhibiting ETEC growth. In addition, two types of probiotics, Lactobacillus 0111 and 0115, were shown to be the most efficient at inhibiting ETEC. The results of studies with mice indicated that the administration of individual TCMs or probiotic strains increased the growth of mice to a different extent. Specifically, the fermentation of Fructus mume, Galla chinensis and Herba taraxaci by the Lactobacillus 0111 strain enhanced their antibacterial ability compared with traditional Jade screen, possibly due to the presence of a compound producing an absorption peak with a retention time of 19.5 min by HPLC. The fermentation of TCMs by probiotic strain provides a novel approach to relieve the effects of the ETEC strain K88.

Pharmacological Mechanisms of Shangke Huangshui against Skin and Soft Tissue Infection

“…Herein, some traditional treatments have played a role in treating SSTIs, such as traditional Chinese medicine (TCM). TCM displays multiple target sites and little toxic effects and has been confirmed to be effective in the treatment of infections caused by certain bacteria, such as salmonella [ 8 , 9 ] and Escherichia coli [ 10 , 11 ]. Chinese medicine compound preparations have increasingly become a research hotspot with varieties of biologically active ingredients, multiefficacy in clinical application and broad antibacterial spectrum.…”