Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives

Ide, Kazuki; Matsuoka, Norihiro; Yamada, Hiroshi; Furushima, Daisuke; Kawakami, Koji

doi:10.3390/molecules23092357

Cited by 85 publications

(45 citation statements)

References 93 publications

(101 reference statements)

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“…An association between the consumption of tea, rich in catechins, and the reduced risk of AD have been reported. Tea has been suggested to have anti-amyloid effects [43] and ameliorate cognitive dysfunction [44]. These effects have been mainly ascribed to the antioxidant and anti-inflammatory effects of tea catechins, but the inhibition of acetylcholinesterase by EGCG may contribute to this effect.…”

Section: Discussionmentioning

confidence: 99%

Interaction of Catechins with Human Erythrocytes

et al. 2020

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The aim of this study was to characterize the interaction of chosen catechins ((+)-catechin, (−)-epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG)) with human erythrocytes and their protective effects against oxidative damage of erythrocytes. Uptake of the catechins by erythrocytes was studied by fluorimetry, their interaction with erythrocyte membrane was probed by changes in erythrocyte osmotic fragility and in membrane fluidity evaluated with spin labels, while protection against oxidative damage was assessed by protection against hemolysis induced by permanganate and protection of erythrocyte membranes against lipid peroxidation and protein thiol group oxidation. Catechin uptake was similar for all the compounds studied. Accumulation of catechins in the erythrocyte membrane was demonstrated by the catechin-induced increase in osmotic resistance and rigidification of the erythrocyte membrane detected by spin labels 5-doxyl stearic acid and 16-doxyl stearic acid. (−)-Epigallocatechin and EGCG inhibited erythrocyte acetylcholinesterase (mixed-type inhibition). Catechins protected erythrocytes against permanganate-induced hemolysis, oxidation of erythrocyte protein thiol groups, as well as membrane lipid peroxidation. These results contribute to the knowledge of the beneficial effects of catechins present in plant-derived food and beverages.

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Section: Discussionmentioning

confidence: 99%

Interaction of Catechins with Human Erythrocytes

et al. 2020

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“…Furthermore, in a double-blind controlled study, type 2 diabetes patients had improvements in obesity and glucose levels after 582.8 mg or 96.3 mg consumption of catechins for 12 weeks [235]. Bone health improvements and Alzheimer's disease prevention by catechins in pre-clinical and clinical studies were summarized somewhere else [236,237].…”

Section: Catechinsmentioning

confidence: 99%

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

et al. 2020

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Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a consequence of the pathological functioning of the nervous system rather than only a symptom. In fact, pain is a significant social, health, and economic burden worldwide. Flavonoids are plant derivative compounds easily found in several fruits and vegetables and consumed in the daily food intake. Flavonoids vary in terms of classes, and while structurally unique, they share a basic structure formed by three rings, known as the flavan nucleus. Structural differences can be found in the pattern of substitution in one of these rings. The hydroxyl group (-OH) position in one of the rings determines the mechanisms of action of the flavonoids and reveals a complex multifunctional activity. Flavonoids have been widely used for their antioxidant, analgesic, and anti-inflammatory effects along with safe preclinical and clinical profiles. In this review, we discuss the preclinical and clinical evidence on the analgesic and anti-inflammatory proprieties of flavonoids. We also focus on how the development of formulations containing flavonoids, along with the understanding of their structure-activity relationship, can be harnessed to identify novel flavonoid-based therapies to treat pathological pain and inflammation.

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“…Moreover, the authors demonstrated that the levels of lipid peroxides in the hippocampus and plasma, and ROS were over 20% lower than in the control group. The antioxidative properties of catechins result from both their radical activity and their ability to chelate the prooxidative Fe 3+ ad Cu 2+ ions (which inhibits Fenton's reaction) [126]. It is known that said ions accumulate in the brains of patients suffering from AD [127].…”

Section: Phenolic Compoundsmentioning

confidence: 99%

“…Clinical studies pertaining to antioxidative therapies with potential application to neurodegenerative diseases have been very intensive in the recent years. In 2018 alone, in the USA and many European and Asian countries, over 10 clinical studies were conducted that pertained solely to the impact of catechins on the development of AD [126]. Simultaneously, other antioxidants and other neurodegenerative diseases are also being analyzed.…”

Section: Antioxidative Therapies In Neurodegenerative Diseases-clinicmentioning

confidence: 99%

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

et al. 2020

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Neurodegenerative diseases are progressive diseases of the nervous system that lead to neuron loss or functional disorders. Neurodegenerative diseases require long-term, sometimes life-long pharmacological treatment, which increases the risk of adverse effects and a negative impact of pharmaceuticals on the patients' general condition. One of the main problems related to the treatment of this type of condition is the limited ability to deliver drugs to the brain due to their poor solubility, low bioavailability, and the effects of the blood-brain barrier. Given the above, one of the main objectives of contemporary scientific research focuses on the prevention of neurodegenerative diseases. As disorders related to the competence of the antioxidative system are a marker in all diseases of this type, the primary prophylactics should entail the use of exogenous antioxidants, particularly ones that can be used over extended periods, regardless of the patient's age, and that are easily available, e.g., as part of a diet or as diet supplements. The paper analyzes the significance of the oxidoreductive balance in the pathogenesis of neurodegenerative diseases. Based on information published globally in the last 10 years, an analysis is also provided with regard to the impact of exogenous antioxidants on brain functions with respect to the prevention of this type of diseases.

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Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives

Cited by 85 publications

References 93 publications

Interaction of Catechins with Human Erythrocytes

Interaction of Catechins with Human Erythrocytes

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

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