2007
DOI: 10.1291/hypres.30.49
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Effects of Telmisartan and Losartan on Insulin Resistance in Hypertensive Patients with Metabolic Syndrome

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Cited by 51 publications
(43 citation statements)
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References 29 publications
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“…Therefore, although the results appear to be different from previous studies, our study is still reliable. Similar to Bahadir et als' study (30), we found no significant change in fasting plasma insulin levels, fasting plasma glucose and calculated HOMA-IR values at the end of the study compared to initial vaules. However, in telmisartan to losartan switching group there was a significant improvement in terms of insulin sensitivity calculated by HECT.…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…Therefore, although the results appear to be different from previous studies, our study is still reliable. Similar to Bahadir et als' study (30), we found no significant change in fasting plasma insulin levels, fasting plasma glucose and calculated HOMA-IR values at the end of the study compared to initial vaules. However, in telmisartan to losartan switching group there was a significant improvement in terms of insulin sensitivity calculated by HECT.…”
Section: Discussionsupporting
confidence: 89%
“…In Vitale and colleagues' study, in patients with newly diagnosed hypertension and metabolic syndrome, fasting glucose, insulin and HOMA scores dropped significantly in the telmisartan group compared to losartan (29). In Bahadir et al study; in hypertensive patients with metabolic syndrome, telmisartan and losartan had neutral effects on insulin resistance calculated by HOMA-IR (30). Our study's results are interestingly different from these comparing studies.…”
Section: Discussioncontrasting
confidence: 82%
“…In fact, some authors observed an improvement in insulin resistance associated with a reduction in ADN, 28 others observed improvements of both 29 and still others found no improvement at all. 30 Adiponectin is a protein exclusively synthesized by adipocytes; it is decreased in obesity and inversely related to glucose and insulin. 31 Ablation of the ADN gene in mice results in insulin resistance, glucose intolerance, dyslipidemia and increased susceptibility to vascular injury and atherosclerosis.…”
Section: Correlationsmentioning
confidence: 99%
“…39 Masuda et al 40 reported that telmisartan reduced proteinuria and improved the ambulatory short-term BP variability in type 2 DM patients compared with losartan. However, Bahadir et al 41 reported that telmisartan and losartan had neutral effects on insulin resistance in hypertensive MetS patients. In the present study, we did not detect ameliorating effects of telmisartan on glucose and lipid metabolism and renal function over the 1-year follow-up.…”
Section: Discussionmentioning
confidence: 99%