Effects of temperature control on hyperthermia-related cardiac dysfunction in a porcine model of cardiac arrest

Wang, Dongxia; Sun, Yuanyuan; Kong, Fang; Jiang, Yi; An, Meng-Meng; Xia, Yunlong; Gong, Ping; Yang, Yanzong

doi:10.1016/j.cryobiol.2022.12.017

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2024

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“…Increase apoptosis was found in rats after CA-CPR along with increased caspase-3 expression after resuscitation . Similar results were reported in pigs that underwent CA-CPR (Wang, et al,2023). We found that the level of apoptosis in cardiomyocytes increased significantly after CPR whereas administration of healthy mitochondria significantly reduced cardiomyocyte apoptosis.…”

Section: Discussionsupporting

confidence: 89%

Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

Wang,

Zhu,

et al. 2024

Preprint

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The incidence of post-cardiac arrest myocardial dysfunction (PAMD) is high, and there is currently no effective treatment available. This study aims to investigate the protective effects of exogenous mitochondrial transplantation. Exogenous mitochondrial transplantation can enhance myocardial function and improve the survival rate. Mechanistic studies suggest that mitochondrial transplantation can limit impairment in mitochondrial morphology, augment the activity of mitochondrial complexes II and IV, and raise ATP levels. As well, mitochondrial therapy ameliorated oxidative stress imbalance, reduced myocardial injury, and thus improved PAMD after cardiopulmonary resuscitation (CPR).

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Section: Discussionsupporting

confidence: 89%