The growing attention regarding aluminum alloy matrix composites within the aerospace, automotive, defense, and transportation industries make the development of new engineering materials with the improved mechanical properties. Currently, materials are selected because of their abilities to satisfy engineering demands high for strength-to-weight ratio, tensile strength, corrosion resistance, and workability. These properties make aluminum alloys and aluminum matrix composites (AMCs) an excellent option for various industrial applications. Soft computing methods such as the artificial neural network (ANN), adaptive-neuro fuzzy inference systems (ANFIS), and Taguchi with ANOVA are the most important approaches to solve the details of the mechanism and structure of materials. The optimal selection of variables has important effects on the final properties of the alloys and composites. The chapter presents original research papers from our works and taken from literature studies dealing with the theory of ANN, ANFIS, and Taguchi, and their applications in engineering design and manufacturing of aluminum alloys and AMCs. Also, the chapter identifies the strengths and limitations of the techniques. The ANFIS and ANN approaches stand out with wide properties, optimization, and prediction, and to solving the complex problems while the Taguchi experimental design technique provides the optimum results with fewer experiments.