Effects of Ten Different Exercise Interventions on Motor Function in Parkinson’s Disease Patients—A Network Meta-Analysis of Randomized Controlled Trials

Hao, Zikang; Zhang, Xiaodan; Chen, Ping

doi:10.3390/brainsci12060698

Cited by 16 publications

(13 citation statements)

References 95 publications

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“…This may be correlated to the limited number of studies included in that study (merely three studies). 37 In addition, the conclusions of the present review were similar to those reported by another review, in which Baduanjin practice is beneficial for balance and trunk flexibility. However, that study included a population of healthy or people with different types of diseases.…”

Section: Discussionsupporting

confidence: 88%

“…The present findings are contrary to Hao’s review, which explored the effects of 10 different exercise interventions on motor function in PD, and revealed that Baduanjin has no benefit for patients with PD. This may be correlated to the limited number of studies included in that study (merely three studies) 37. In addition, the conclusions of the present review were similar to those reported by another review, in which Baduanjin practice is beneficial for balance and trunk flexibility.…”

Section: Discussionsupporting

confidence: 86%

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Effects of Baduanjin exercise on motor function, balance and gait in Parkinson’s disease: a systematic review and meta-analysis

et al. 2022

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ObjectiveThis study aims to systematically evaluate the effects of Baduanjin on motor function, balance and gait in patients with Parkinson’s disease (PD).DesignSystematic review and meta-analysis.Study selectionAll eligible randomised controlled trials (RCTs) published in the English and Chinese language were included.Data sourcesTen electronic databases were systematically searched, from inception to 17 March 2022: PubMed, Web of Science, Cochrane Library, Embase, EBSCOhost, OVID, SinoMed, China National Knowledge Infrastructure, Wanfang Data and China Science Journal Database (VIP).Review methodsMethodological quality assessment and meta-analysis were performed for the included studies using the Cochrane Review Manager V.5.4 software.ResultsTen RCTs with 804 participants were included. The results revealed the following: (1) Baduanjin significantly improved the motor function of patients with PD, based on the Unified Parkinson’s Disease Rating Scale Part III (mean difference, MD −5.37, 95% CI −8.96 to −1.78, p=0.003) and Fugl-Meyer Assessment of Lower Extremity (MD 5.39, 95% CI 2.71 to 8.07, p<0.0001); (2) Baduanjin significantly improved the ability of balance of patients with PD, based on the Berg Balance Scale (MD 4.40, 95% CI 3.08 to 5.73, p<0.00001); (3) Baduanjin significantly improved the gait of patients with PD, based on the 6 min walk distance (MD 21.62, 95% CI 11.14 to 32.10, p<0.0001). After the further subgroup and sensitivity analyses, the heterogeneity was identified to be potentially due to the different degrees of disease severity in patients with PD and the difference in Baduanjin intervention durations.ConclusionsThe analysis of this systematic evaluation indicates that Baduanjin might have a positive effect in improving the motor function, balance and gait of patients with PD. However, due to the quantity and clinical heterogeneity limitations of the included studies, this conclusion still warrants more high-quality and multicentre RCTs for further verification.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 86%

Effects of Baduanjin exercise on motor function, balance and gait in Parkinson’s disease: a systematic review and meta-analysis

et al. 2022

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“…Concerning motor aspects, after treatment, we observed an improvement in global motor functioning (MDS-UPDRS—part III) and a reduction in the disability of the upper limbs (DASH), which was maintained at follow-up. These data are in line with evidence reported in the literature [ 62 , 63 , 64 ].…”

Section: Discussionsupporting

confidence: 93%

Effect of Upper Limb Motor Rehabilitation on Cognition in Parkinson’s Disease: An Observational Study

et al. 2022

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Parkinson’s disease is characterized by motor and cognitive deficits that usually have an impact on quality of life and independence. To reduce impairment, various rehabilitation programs have been proposed, but their effects on both cognitive and motor aspects have not been systematically investigated. Furthermore, most intervention is focused on lower limb treatment rather than upper limbs. In the present study, we investigated the effect of 3-week upper limb vibratory stimulation training on cognitive functioning in 20 individuals with Parkinson’s disease. We analyzed cognitive (Montreal Cognitive Assessment, Trial Making Test, Digit Symbol, Digit Span Forward and Backward and Alertness) and motor performance (Unified Parkinson’s Disease Rating Scale—part III; Disability of the Arm, Shoulder and Hand Questionnaire) before treatment, at the end of treatment and one month post treatment. After rehabilitation, a statistically significant improvement was observed in terms of global cognitive status, attention, global motor functioning and disability. The results suggest an impact of upper limb motor rehabilitation on cognition in Parkinson’s disease. Future studies on neuromotor interventions should investigate their effects on cognitive functioning to improve understanding of cognitive motor interaction in Parkinson’s disease.

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“…The size of each node and the width of connecting lines are proportional to the number of studies ( 20 )。To help explain the diagnostic performance, the Surface Under the Cumulative Ranking Curve (SUCRA) ( 21 ) was used to calculate the probability of each urine marker and was the most efficient diagnostic method based on a Bayesian approach using probability values, the greater the SUCRA value, the higher the diagnostic performance rating of the urine marker. This study used a funnel plot test to determine publication bias ( 22 ). If the inverted funnel plot is asymmetric, publication bias may exist; otherwise, there is no apparent publication bias.…”

Section: Methodsmentioning

confidence: 99%

Accuracy of novel urinary biomarker tests in the diagnosis of prostate cancer: A systematic review and network meta-analysis

Wang

He²,

Shi³

et al. 2022

Front. Oncol.

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ObjectiveThe purpose of this study was to conduct a network meta-analysis comparing the diagnostic value of different urinary markers for prostate cancer.MethodsAs of June 2022, the literature was retrieved by searching Pubmed, EMBASE, Web of Science databases and other databases. The methodological quality of included studies was assessed using the Cochrane Collaboration’s risk of bias tool, and publication bias was assessed using funnel plots. The surface under the cumulative ranking curve (SUCRA) values was used to determine the most effective diagnostic method and the data were analyzed accordingly using data analysis software.ResultsA total of 16 articles was included including 9952 patients. The ranking results of network meta-analysis showed that the diagnostic performance of the four urine markers Selectmdx, MIPS, PCA3 and EPI was better than that of PSA. Among them, the specificity, positive predictive value and diagnostic accuracy of Selectmdx ranked first in the SUCRA ranking (SUCRA values: 85.2%, 88.3%, 97.1%), and the sensitivity ranked second in the SUCRA ranking (SUCRA value: 54.4%), and the negative predictive value ranked fourth in SUCRA (SUCRA value: 51.6%). The most sensitive screening tool was MIPS (SUCRA value: 67.1%), and it was also the second screening tool ranked higher in specificity, positive predictive value, negative predictive value and diagnostic accuracy (SUCRA value: 56.5%, respectively)., 57.1%, 67.9%, 74.3%). The high negative predictive value SUCRA ranking is EPI (SUCRA value: 68.0%), its sensitivity ranks third (SUCRA value: 45.6%), and its specificity, positive predictive value and diagnostic accuracy are ranked fourth (SUCRA values are: 45%, 38.2%, 35.8%).ConclusionAccording to the network ranking diagram, we finally concluded that Selectmdx and MIPS can be used as the most suitable urine markers for prostate cancer screening and diagnosis. To further explore the diagnostic value of different urinary markers in the screening of PCa patients.Systematic Review Registrationhttps://inplasy.com/, identifier INPLASY202290094.

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Effects of Ten Different Exercise Interventions on Motor Function in Parkinson’s Disease Patients—A Network Meta-Analysis of Randomized Controlled Trials

Cited by 16 publications

References 95 publications

Effects of Baduanjin exercise on motor function, balance and gait in Parkinson’s disease: a systematic review and meta-analysis

Effects of Baduanjin exercise on motor function, balance and gait in Parkinson’s disease: a systematic review and meta-analysis

Effect of Upper Limb Motor Rehabilitation on Cognition in Parkinson’s Disease: An Observational Study

Accuracy of novel urinary biomarker tests in the diagnosis of prostate cancer: A systematic review and network meta-analysis

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