Effects of Testosterone and Estradiol-17.BETA. on Progesterone Production by Granulosa Cells of the Hen.

Caicedo, Ricardo E.; Fukaya, Masanori; Goto, Hisaya; Kawashima, Mitsuo; Kamiyoshi, Michiharu

doi:10.2141/jpsa.34.147

Cited by 1 publication

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Asem and Hertelendy (1986) showed that TAM administration inhibits P450scc in hen granulosa cells. On the other hand, it has been demonstrated that culture of hen granulosa cells with oestradiol significantly increased progesterone production in response to LH (Kamiyoshi et al, Acta Veterinaria Hungarica 57, 2009 1992; Caicedo et al, 1997). Similar effects were observed in respect to granulosa cells of Japanese quails by Sasanami and Mori (1999).…”

Section: (A) (B)mentioning

confidence: 83%

“…They stimulate the growth of the oviduct, induce synthesis of several egg proteins in the oviduct and the liver, and are involved in egg shell formation (Sakimura et al, 2001;Dougherty and Sanders, 2005). Moreover, oestrogens influence P4 production by granulosa cells of the hen ovarian follicles Caicedo et al, 1997;Sasanami and Mori, 1999). The effects of these steroids in the target cells are mediated by oestrogen receptors (ERs) which are expressed not only in the ovary and oviduct but also in several other tissues, including the hypothalamus and pituitary gland (Gasc and Baulieu, 1988;Hrabia et al, 2004).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effect of tamoxifen on sex steroid concentrations in chicken ovarian follicles

Rzasa

Sechman

Paczoska-Eliasiewicz

et al. 2009

Acta Veterinaria Hungarica

View full text Add to dashboard Cite

The aim of the present investigation was to study the effect of tamoxifen (TAM), an oestrogen receptor antagonist, on the concentrations of sex hormones in chicken ovarian follicles. The experiment was carried out on Hy-line hens which were randomly divided into two groups (control and experimental). TAM was given at a dose of 4 mg/hen (per os) at first once a day for 7 consecutive days, and subsequently four times a day for the next 6 days. Control hens received placebo. Birds were killed on the day after the last TAM treatment. From the dissected ovaries the following compartments were isolated: stroma with follicles < 1 mm, white non-hierarchical (1-4 mm and 4-8 mm) and yellow hierarchical follicles (F6-F1; 18-35 mm). The concentrations of the sex steroids progesterone (P4), testosterone (T) and oestradiol (E2) in the ovarian follicles were determined by radioimmunoassay. In the TAM-treated group, a gradual decrease in egglaying rate was observed from the 4th day of the experiment. Eventually, egg laying stopped entirely on the 12th day of the experiment. TAM significantly decreased the weight of the ovary and affected the sex hormone concentrations in the ovarian follicles. Following TAM treatment (1) a significant increase in E2 and T concentrations in the stroma, white follicles and the F4 and F1 follicles, (2) a significant decrease in E2 and T concentrations in the F2 follicle, and (3) a significant decline of P4 in the F4 to F1 follicles were observed. The results indicate that the blockade of oestrogen receptors by TAM significantly modulates the process of chicken ovarian steroidogenesis.

show abstract

Section: (A) (B)mentioning

confidence: 83%