Effects of testosterone buciclate on testicular and epididymal sperm functions in bonnet monkeys (Macaca radiata)

Kinger, S.; Pal, P. C.; Rajalakshmi, M.; Kumar, Praveen; Sharma, Dipika; Bajaj, J. S.

doi:10.1016/s0010-7824(95)00135-2

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…The effects of administration of T alone on spermatogenesis have also been studied in macaques with seasonal reproductive activity (Tyagi et al, 1999). In the bonnet monkey, administration of TB induced a reduction of sperm numbers but failed to cause azoospermia (Kinger et al, 1995). It must be taken into account, however, that seasonal macaques might represent a special model because it has been claimed—in the case of the bonnet monkey—that merely blocking the nocturnal T surge provokes suppression of spermatogenesis (Suresh et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Degree of Aromatization Rather Than Total Dose of Different Preparations Determine the Effects of Testosterone: A Nonhuman Primate Study in Macaca fascicularis

Weinbauer

Partsch

Zitzmann

et al. 2003

Journal of Andrology

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Currently available testosterone (T) preparations differ substantially in their pharmacokinetic profile that might influence their androgenic properties in terms of suppression of the gonadal axis, effects on anabolic parameters, lipid metabolism, and erythropoiesis. The present work was undertaken to determine the physiological effects of three T preparations with different serum kinetics. Twenty adult male cynomolgus monkeys (Macaca fascicularis) were randomly assigned to receive treatment for 28 weeks with either T enanthate (TE) every 4 weeks, T buciclate (TB) every 7 weeks, or T undecanoate (TU) every 10 weeks or remaining untreated (controls). Each injection delivered 20 mg pure T per kilogram body weight. Pharmacokinetic profiles demonstrated higher peak levels of T for TE-treated animals; serum half-lives were longer for TU or TB. Estradiol levels (area under the curve) were significantly higher in TB vs TU or TE. All T regimens suppressed serum luteinizing hormone bioactivity and testicular volumes declined (all P <.001 vs controls). Sperm counts were markedly lowered in all animals but least in TE (P <.01 vs TB or TU). During recovery phase, return to normal for all three parameters occurred significantly earlier in TE-treated animals, followed by those given TU, compared with TB (all P <.001 between groups). Body weight increased significantly during T exposure. This effect was stronger and more sustained in TB vs TU or TE (both P <.001). Serum creatinine and hemoglobin increased with high significance in all T-treated animals (all P <.001 vs controls). The lowering impact of T on serum lipids was markedly stronger in the longer-acting T preparations in comparison with TE, as were effects on purine metabolism (all P <.001). The pattern of exposure and degree of aromatization rather than overall exposure to T determine its effects in the preclinical primate model. Both fluctuations of androgen concentrations and the conversion rate to estradiol influence gonadal suppression as well as metabolism. These results have to be considered in men receiving treatment for hypogonadism or regimens for hormonal contraception.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Degree of Aromatization Rather Than Total Dose of Different Preparations Determine the Effects of Testosterone: A Nonhuman Primate Study in Macaca fascicularis

Weinbauer

Partsch

Zitzmann

et al. 2003

Journal of Andrology

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“…Para estudos de criopreservação de sêmen, ver Tabelas 1 e 2. Macaca nemestrina REZNICHECK et al, 1968;SCHAFFER et al, 1989bMacaca nigra THOMSON et al, 1992Macaca radiata KALLA et al, 1986KINGER et al, 1995;RAMESH et al, 1998Macaca silenus SCHAFFER et al, 1989aAUSTIN, 1967a, b Macaca tibetana SHANGCHUAN et al, 1994AUSTIN, 1967a, b;KEELING, 1974;BADER, 1983;MARSON et al, 1988;MARSON et al, 1989;YOUNG, 1990;SMITHWICK;GOULD, 1995;AGCA et al, 2005;O'BRIEN et al, 2003 animal e tem altas taxas de sucesso (MORELAND et al, 2001;VALLE et al, 2004;CARVALHO et al, 2014). Já para espécies pequenas, como é o caso dos calitriquídeos, pode-se utilizar a técnica de vibroestimulação peniana (YEOMAN et al, 1997b;KUEDERLING et al, 2000;MASSAROTTO et al, 2010;HENRIQUE et al, 2013 resultados, dentre as enzimas testadas.…”

Section: Aos Animaisunclassified

<b>Criopreservação de sêmen de primatas não-humanos</b>

Carvalho¹

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Aos meus irmãos, Mateus e Paulo, pelos conselhos e por sempre "estarem lá" À minha grande família, incluindo tios, tias, primos e primas, pelo apoio incondicional e reuniões descontraídas.Aos meus amigos e amigas que, de longe ou de perto, sempre fizeram a diferença.Ao meu coorientador e amigo, Prof. Rodrigo R. Valle, por ter me incentivado e me ajudado a entrar na pós-graduação; por ter me introduzido à área de À técnica e amiga Cathy Ramsey, do ART Core, que me ajudou durante toda a realização do meu projeto da BEPE.À pesquisadora, Dra. Carol Hanna, que atuou como co-supervisora do meu projeto da BEPE, contribuindo tanto na elaboração como na execução do projeto.Aos demais integrantes do Hennebold Lab, Melinda, Nathan, Jill e Alison, pela ajuda e convivência.À pesquisadora e amiga, Dra. Naida Loskutoff (in memoriam) do Omaha's Henry Doorly Zoo, que também nos deixou precocemente no último ano, pelo fornecimento do corante eosina-fast green. Às instituiçõesAgradeço a todas as instituições que tornaram possível a realização dos meus estudos e pesquisas. No Brasil À Faculdade de Medicina Veterinária e Zootecnia da Universidade de SãoPaulo (FMVZ/USP) por fornecer toda a estrutura técnico-científica para realização do meu Doutorado. Primate Research Center (OHSU) por fornecer toda a estrutura e apoio técnico e financeiro para realização do meu projeto de pesquisa no exterior. Aos AnimaisAgradeço também, aos primatas não-humanos, nossos passivos e inocentes parceiros dessa jornada. better results when compared to vitrification (p<0,05). SW had better results, followed by DGC and SU, while GWF had the worse results. SW and DGC were further evaluated by IVF. Fertilization rates (mean±SEM%) with MI oocytes using fresh sperm were significantly higher (43.5±16.4) than with SW (2.0±2.0) and did not differ from DGC (25.1±14.2). There was no difference in blastocyst rates between treatments (range 0 to 11.9±7.9). Fertilization rates with MII ova were also significantly higher with fresh sperm (41.4±3.6) than DGC and SW (18.4±6.9 and 12.7±7.7, respectively), and more blastocysts developed from MIIs fertilized with fresh sperm (64.7±13.6) than SW and DGC (4.7±4.7 and 30.9±13.8, respectively). In conclusion, frozen-thawed sperm were able to fertilize oocytes and embryos reached the blastocyst stage. DGC yielded better frozen-thawed sperm for IVF in rhesus macaques, when compared with SW.

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The reproductive toxicity of organic compounds extracted from drinking water sources on Sprague Dawley rats: An in vitro study

Wang

et al. 2010

Environmental Toxicology

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The safety of drinking water always causes worldwide concern. Water pollution increases with urban development and industrialization in developing countries. During recent decades, increasing numbers of environmental organic compounds have been found in aquatic environments. These organic compounds are capable of bioaccumulating to much higher concentrations in food webs and cause health effects on human beings. Reproductive impairment is one of the commonest consequences of environmental pollution. Our goal was to investigate the reproductive toxicity of organic compounds extracted from surface water samples collected in drinking water sources. This study focused on the surface water in lower Yangtze River and Taihu Lake, which act as drinking water sources of Jiangsu province, one of the most rapidly developing regions in China. We used solid-phase extraction (SPE) to condense organic compounds by 286 times from natural surface water samples and established in vitro system to evaluate their effects on reproductive system. We found that organic compounds destroyed the plasma membrane integrity of Sertoli cells and Spermatogenic cells to a certain degree and significantly depressed viability of Sertoli cells and Spermatogenic cells as well. Accordingly, the proportion of apoptotic Sertoli cells and dead Spermatogenic cells enhanced markedly. Although viability of organic-compound-treated Leydig cells did not come down remarkably, testosterone production of Leydig cells decreased evidently. These results suggest that accumulated comprehensive effects of organic compounds in surface water of drinking water sources may induce spermatogenesis malfunction and reduction of testosterone production in the long term.

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Effects of testosterone buciclate on testicular and epididymal sperm functions in bonnet monkeys (Macaca radiata)

Cited by 9 publications

References 30 publications

Pharmacokinetics and Degree of Aromatization Rather Than Total Dose of Different Preparations Determine the Effects of Testosterone: A Nonhuman Primate Study in Macaca fascicularis

Pharmacokinetics and Degree of Aromatization Rather Than Total Dose of Different Preparations Determine the Effects of Testosterone: A Nonhuman Primate Study in Macaca fascicularis

<b>Criopreservação de sêmen de primatas não-humanos</b>

The reproductive toxicity of organic compounds extracted from drinking water sources on Sprague Dawley rats: An in vitro study

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