Effects of testosterone on attention and memory for emotional stimuli in male rhesus monkeys

King, Hanna M.; Kurdziel, Laura B. F.; Meyer, Jerrold S.; Lacreuse, Agnès

doi:10.1016/j.psyneuen.2011.07.010

Cited by 37 publications

(37 citation statements)

References 92 publications

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“…The dot-probe task is specifically suitable for comparative studies as the task can be conducted with nonhuman primates (King et al, 2012;Kret et al, 2016;Parr et al, 2013) and potentially also with other animals. Moreover, rhesus monkeys perform similar to humans when facial stimuli are used (Lacreuse et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…We found three studies in which the dot-probe task was performed with nonhuman primates (King et al, 2012;Kret et al, 2016;Parr et al, 2013). These studies showed that both rhesus monkeys (King et al, 2012) and bonobos (Kret et al, 2016) were significantly faster in reacting to a dot replacing an emotional picture than to a dot replacing a neutral picture. The study by Kret et al (2016) also described an enhanced effect for the photographs that the keepers rated as particularly emotionally intense.…”

Section: Review Of Dot-probe Studiesmentioning

confidence: 99%

“…To gain insight into the above-posed questions, we will focus this review on emotional attention and specifically, on the usability of a task that can measure this implicitly. The dot-probe task is a paradigm that is often used in psychology and has a lot of potential for testing emotional attention across primate species, primarily because this test is implicit and because evidence, although still scarce, is accumulating that it does not require verbal instruction and that subjects need no or minimal training to perform the test successfully (King, Kurdziel, Meyer, & Lacreuse, 2012;Kret, Jaasma, Bionda, & Wijnen, 2016;Parr, Modi, Siebert, & Young, 2013).…”

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confidence: 99%

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The dot-probe task to measure emotional attention: A suitable measure in comparative studies?

2017

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For social animals, attending to and recognizing the emotional expressions of other individuals is of crucial importance for their survival and likely has a deep evolutionary origin. Gaining insight into how emotional expressions evolved as adaptations over the course of evolution can be achieved by making direct cross-species comparisons. To that extent, experimental paradigms that are suitable for investigating emotional processing across species need to be developed and evaluated. The emotional dot-probe task, which measures attention allocation toward emotional stimuli, has this potential. The task is implicit, and subjects need minimal training to perform the task successfully. Findings in nonhuman primates, although scarce, show that they, like humans, have an attentional bias toward emotional stimuli. However, the wide literature on human studies has shown that different factors can have important moderating effects on the results. Due to the large heterogeneity of this literature, these moderating effects often remain unnoticed. We here review this literature and show that subject characteristics and differences in experimental designs affect the results of the dot-probe task. We conclude with specific recommendations regarding these issues that are particularly relevant to take into consideration when applying this paradigm to study animals.

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Section: Resultsmentioning

confidence: 99%

Section: Review Of Dot-probe Studiesmentioning

confidence: 99%

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confidence: 99%

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The dot-probe task to measure emotional attention: A suitable measure in comparative studies?

2017

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“…Exogenous testosterone moderated attentional responses to threatening stimuli (Lacreuse et al 2010;van Honk et al 2005). Testosterone might particularly increase attentional biases to negative stimuli during early exposure to the stimuli accompanied by acute treatment, or when the stimuli are highly aroused by chronic treatment (King et al 2012). P3a reflects involuntary attentional switches caused by novel stimuli (Harmony et al 2000).…”

Section: Discussionmentioning

confidence: 96%

Testosterone modulates preattentive sensory processing and involuntary attention switches to emotional voices

Chen¹,

Chen

Yang

et al. 2015

Journal of Neurophysiology

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Testosterone is capable of altering facial threat processing. Voices, similar to faces, convey social information. We hypothesized that administering a single dose of testosterone would change voice perception in humans. In a placebo-controlled, randomly assigned, double-blind crossover design, we administered a single dose of testosterone or placebo to 18 healthy female volunteers and used a passive auditory oddball paradigm. The mismatch negativity (MMN) and P3a in responses to fearfully, happily, and neutrally spoken syllables dada and acoustically matched nonvocal sounds were analyzed, indicating preattentive sensory processing and involuntary attention switches. Results showed that testosterone administration had a trend to shorten the peak latencies of happy MMN and significantly enhanced the amplitudes of happy and fearful P3a, whereas the happy- and fearful-derived nonvocal MMN and P3a remained unaffected. These findings demonstrated acute effect of testosterone on the neural dynamics of voice perception. Administering a single dose of testosterone modulates preattentive sensory processing and involuntary attention switches in response to emotional voices.

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“…The present study evaluated the effects of IN-OT and IN-Placebo on social perception in rhesus monkeys using a well-known attention task, the dot-probe task (King et al, 2012; MacLeod et al, 1986). Two interesting findings emerged.…”

Section: Discussionmentioning

confidence: 99%

Intranasal oxytocin selectively attenuates rhesus monkeys’ attention to negative facial expressions

Parr

Modi

Siebert³

et al. 2013

Psychoneuroendocrinology

123

118

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Intranasal oxytocin (IN-OT) modulates social perception and cognition in humans and could be an effective pharmacotherapy for treating social impairments associated with neuropsychiatric disorders, like autism. However, it is unknown how IN-OT modulates social cognition, its effect after repeated use, or its impact on the developing brain. Animal models are urgently needed. This study examined the effect of IN-OT on social perception in monkeys using tasks that reveal some of the social impairments seen in autism. Six rhesus macaques (Macaca mulatta, 4 males) received a 48 IU dose of OT or saline placebo using a pediatric nebulizer. An hour later, they performed a computerized task (the dot-probe task) to measure their attentional bias to social, emotional, and nonsocial images. Results showed that IN-OT significantly reduced monkeys’ attention to negative facial expressions, but not neutral faces or clip art images and, additionally, showed a trend to enhance monkeys’ attention to direct versus averted gaze faces. This study is the first to demonstrate an effect of IN-OT on social perception in monkeys, IN-OT selectively reduced monkey’s attention to negative facial expressions, but not neutral social or nonsocial images. These findings complement several reports in humans showing that IN-OT reduces the aversive quality of social images suggesting that, like humans, monkey social perception is mediated by the oxytocinergic system. Importantly, these results in monkeys suggest that IN-OT does not dampen the emotional salience of social stimuli, but rather acts to affect the evaluation of emotional images during the early stages of information processing.

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Effects of testosterone on attention and memory for emotional stimuli in male rhesus monkeys

Cited by 37 publications

References 92 publications

The dot-probe task to measure emotional attention: A suitable measure in comparative studies?

The dot-probe task to measure emotional attention: A suitable measure in comparative studies?

Testosterone modulates preattentive sensory processing and involuntary attention switches to emotional voices

Intranasal oxytocin selectively attenuates rhesus monkeys’ attention to negative facial expressions

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