Effects of testosterone replacement on sexual behavior in hypogonadal men

Salmimies, P; Kockott, G.; Pirke, Karl M.; Vogt, Hermann-J.; Schill, W.‐B.

doi:10.1007/bf01541595

Cited by 142 publications

(58 citation statements)

References 5 publications

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“…Studies by other groups have demonstrated that in both men (34,35) and women (20) above a certain minimal value of FT, increasing levels do not result in increased sexual drive. Thus the women in this study behaved in the same way as women without epilepsy who have been studied elsewhere.…”

Section: Discussionmentioning

confidence: 95%

Sexual Function in Women with Epilepsy

et al. 1997

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Summary:Purpose: To examine certain aspects of sexual behaviour and attitudes in a group of women with epilepsy using a validated questionnaire (Sexuality Experience Scales), and effects of antiepileptic drugs (AEDs) on sex hormone binding globulin (SHBG), total testosterone (TT), and free testosterone (FT).Methods: One hundred ninety-five women all attending a hospital-based epilepsy clinic were recruited. One hundred fifty-nine received AED therapy and 36 women did not. A control group of 48 women was also recruited. All women completed the first two Sexuality Experience Scales (SES 1 and SES 2), and those women in stable heterosexual relationships completed SES 3 and SES 4. At the same time blood was taken for TT and SHBG 1evels.FT was calculated using the method of Nanjee and Wheeler (22).Results: Women receiving AED therapy achieved significantly higher SES 1 and SES 2 scores than the rest of the women, suggesting that they adhered to a stricter sexual morality and were less open to psychosexual stimulation than the rest of the women treated. Women in the treated group were less likely to have received further education than the controls, a factor that influences SES 1 and SES 2 scores. There were no significant differences between the three groups on SES 3 or SES 4, with the exception of the orgasmic adequacy (OE) scale of SES 3 where those women in the treated group attained a higher mean score than the controls, suggesting that they found orgasm less satisfying. Women receiving AEDs had significantly higher SHBG and TT than controls and untreated patients. There were no differences in FT between the groups. Those women receiving AEDs also exhibited the expected midcycle rise in FT. There was no significant correlation between FT and the desired frequency of intercourse or enjoyment of it for the three groups.Conclusions: Women in the treated group appeared to be more "moral" and less open to sexual approach, but those who had regular partners appeared to desire and enjoy intercourse as much as the control and untreated groups. This could be explained by differences in demographic characteristics of the study groups or be indicative of a bimodal distribution of sexual interest in these women. As FT was within physiological norms for each study group this cannot be cited as a cause for hyposexuality .

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Section: Discussionmentioning

confidence: 95%

Sexual Function in Women with Epilepsy

et al. 1997

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“…Other investigators (e.g., Salmimies, Kockott, Pirke, Vogt, & Schill, 1982) have reported that providing testosterone replacement therapy to hypogonadal men leads to increases in the frequency of spontaneous erections. Subsequent, more fine-grained analysis suggests that testosterone may be more important to fantasy-based arousal and sexual desire than it is to externally stimulated erections (Bancroft & Wu, 1983).…”

Section: Endocrine Deficienciesmentioning

confidence: 99%

The Effects of False Physiological Feedback on Sexual Arousal in Sexually Dysfunctional and Functional Males

Stone¹

1999

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According to a recent model of psychogenic erectile dysfunction (Sbrocco & Barlow, 1996), dysfunctional performance results from focusing on negative outcome expectancy and low confidence following a discrepancy between expected and actual performance. The purpose of the current study was to manipulate the experience of sexually functional and dysfunctional males to produce a discrepancy between expected and actual performance. Fifty-six sexually functional and 57 sexually dysfunctional men were assigned to one of four groups (negative feedback, neutral feedback. inflated feedback, or no feedback). Penile tumescence was recorded while viewing two 5-minute erotic videotapes. All participants viewed film 1 without feedback. Next. the feedback subjects were told the average score for an erection and were asked to predict the score they would receive during film 2 and how confident they were. While viewing film 2, the negative feedback group received feedback that their scores were below their prediction, the neutral feedback group received feedback that their scores were what they predicted. and the inflated feedback group was shown their scores were higher than predicted. After film 2, they were again asked to predict their scores on a subsequent (bogus) film and rate their confidence.Contrary to the Sbrocco and Barlow model, positive feedback decreased tumescence for both the dysfunctionals and functionals. This occurred. despite an increase in expectancy, confidence, and self-reported arousal. Also in contrast with the Sbrocco and Barlow model, ii negative feedback resulted in decreased outcome expectancy but did not induce a change in tumescence for the dysfunctionals. Finally, negative feedback unexpectedly resulted in decreased tumescence for the functionals.The only variable that predicted changes in tumescence was the self-reported level of surprise concerning the feedback. For both the dysfunctionals and functionals, the feedback groups that experienced a decrease in tumescence were more surprised by the feedback than the groups that experienced no change in tumescence.In conclusion, the present study found that positive expectations for and confidence in functional sexual performance may be necessary but not sufficient factors for successful tumescence. Positive outcome expectancies and confidence may only be useful if the man is not surprised by his performance. LIST OF FIGURESCross section of male pelvic region and cross section of penis Barlow's (1986Barlow's ( , 1988 model of sexual dysfunction Barlow, Sakheim, and Beck's (1983) shock threat paradigm Abrahamson, Barlow, Sakheim, Beck, and Athanasiou's (1985) What we do know is that a sexual situation involves the integration of information from various sensory modalities and sources. Information is internally and externally generated and cognitively processed in order to produce a sexual response. Obtaining and maintaining an erection is a complex process that requires not only normal physiological responding, but also functional cognitive a...

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“…The lack in association is further supported by the observation that testosterone treatment does not significantly alter sexual dysfunction in normogonadotropic men. Merely in hypogonadal men is the sexual activity clearly improved by testosterone substitution, regardless of the mode of application [1,[9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Relation of Sexual Dysfunction to Hormone Levels, Diseases and Drugs Used in Andrological Patients

Krause

Müller²

2000

Urol Int

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In 169 patients visiting our department complaining of sexual dysfunction, the medical history was taken using a semistructured interview. A clinical investigation and a hormone analysis were added. The age of patients, hormone values, and items of the interview were collected into a common database. The items were categorized as either dichotomous (yes/no) or ordinal. Statistical analysis was performed using regression analysis with the aim to generate hypotheses of relations. An increase of FSH levels and a decrease of testosterone levels with age occurred. None of the relations of hormone levels or diseases to symptoms of sexual dysfunction produced odds ratios (OR) statistically significant different from 1. However, the risk of having a reduced libido and reduced morning erections was lower in psychoneurological diseases, the risk of reduced arousal and libido was lower in men with diabetes mellitus, but the risk of reduced morning erections was higher in these men. The testosterone levels were not associated with the risk of having reduced penile rigidity, duration of erection, arousal and sexual libido, reduced morning erections and the ability to masturbate. Smoking was not associated with reduced arousal, libido and morning erections. However, a significant increase of testosterone levels with number of cigarettes used was observed. We conclude that sexual dysfunction in patients visiting an andrological department for diagnosis and treatment is mostly not associated to any single evaluable factor.

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Effects of testosterone replacement on sexual behavior in hypogonadal men

Cited by 142 publications

References 5 publications

Sexual Function in Women with Epilepsy

Sexual Function in Women with Epilepsy

The Effects of False Physiological Feedback on Sexual Arousal in Sexually Dysfunctional and Functional Males

Relation of Sexual Dysfunction to Hormone Levels, Diseases and Drugs Used in Andrological Patients

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