Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study

Zhao, Yan; Wen, Guangdong; Qiao, Zhuanhong; Xu, Hongbo; Sun, Qi; Huang, Heqing; Shan, Shuxiang; Mu, Zhanglei; Zhang, J

doi:10.1177/0961203313478302

Cited by 7 publications

(14 citation statements)

References 29 publications

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“…These results are consistent with our prior study on BXSB mice (Zhao et al, 2013)), and further demonstrate the effect of As 4 S 4 on inhibiting the disease of lupus-prone mice. Realgar, a mined ore, containing about 90% As 4 S 4, was employed to treat a variety of diseases, including syphilis, malignancy, malaria, and Lu reported that oral high-purity As 4 S 4 can be safely used for induction or long-term treatment in most patients with APL (Lu et al, 2001), which engaged our attention to investigate the effect of As 4 S 4 on lupus.…”

Section: Discussionsupporting

confidence: 93%

“…In addition, it presented protective effect on liver and kidney with no obvious toxicity. These results are consistent with our prior study on BXSB mice (Zhao et al, )), and further demonstrate the effect of As 4 S 4 on inhibiting the disease of lupus‐prone mice.…”

Section: Discussionsupporting

confidence: 93%

“…Compared to patients treated with As 4 S 4 , liver and renal protective effect was observed in our study (Zhao et al, 2013). This effect was confirmed in two strains of lupus mice.…”

Section: Discussionsupporting

confidence: 84%

“…No obvious side effect or toxicity was observed (Zhao et al, 2013). MRL/lpr mice displayed sexual dimorphism spontaneously with an accelerated mortality rate.…”

Section: Introductionmentioning

confidence: 87%

“…It has beneficial effects on BXSB mice to decrease monocytosis, reduction of serum interleukin (IL)‐6 and suppression of skin lesions and nephritis. No obvious side effect or toxicity was observed (Zhao et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Tetra-arsenic tetra-sulfide ameliorates lupus syndromes by inhibiting IL-17 producing double negative T cells

Zhao

Cai

et al. 2019

Dermatologic Therapy

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Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Tetra‐arsenic tetra‐sulfide (As4S4), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects. In our previous study, BXSB lupus‐prone mice treated with As4S4 has showed improved monocytosis, decreased serum interleukin (IL)‐6 and suppressed skin, liver and renal lesions with well‐tolerance. In this study, we explored the effect and mechanism of As4S4 on the MRL/lpr mice. MRL/lpr and wild MRL/MpJ mice were divided into control and As4S4 treatment groups and dosed with As4S4 or placebo for 8 weeks. We found that As4S4 prevented the skin, renal and lung lesions of MRL/lpr mice. As4S4 significantly decreased the double negative T (DN T) cells and reduced the serum levels of IL‐17, IL‐10, and antinuclear antibodies titer. Further results revealed that the FasL was decreased, and activated caspases elevated in DN T cells in As4S4 treated MRL/lpr mice. Taken together, As4S4 could selectively suppresses DN T cells by inducing apoptosis. It also reduced inflammatory cytokines IL‐17, which may be produced by DN T cells. As4S4 may represent a new therapy for SLE.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

“…Compared to patients treated with As 4 S 4 , liver and renal protective effect was observed in our study (Zhao et al, 2013). This effect was confirmed in two strains of lupus mice.…”

Section: Discussionsupporting

confidence: 84%

“…No obvious side effect or toxicity was observed (Zhao et al, 2013). MRL/lpr mice displayed sexual dimorphism spontaneously with an accelerated mortality rate.…”

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tetra-arsenic tetra-sulfide ameliorates lupus syndromes by inhibiting IL-17 producing double negative T cells

Zhao

Cai

et al. 2019

Dermatologic Therapy

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Progress in traditional Chinese medicine and natural extracts for the treatment of lupus nephritis

Wang

et al. 2022

Biomedicine & Pharmacotherapy

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Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Gokulan

Arnold

Jensen

et al. 2018

mBio

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Intestinal microbiota composition and gut-associated immune response can contribute to the toxicity of arsenic. We investigated the potential toxicity of short-term arsenic exposure on gut microbiome composition, intestinal immune status, microbial arsenic resistance gene, and arsenic metabolic profiles in adult and developmental stages of CD-1 mice. The potential toxicity of arsenite [As(III)] was determined for two life stages: (i) adult animals at 24 or 48 h after single gavage (0.05 mg/kg body weight [b.w.] [low dose], 0.1 mg/kg b.w. [medium dose], and 0.2 mg/kg b.w. [high dose]) and repeated exposure at 1 mg/liter for 8 days and (ii) postnatal day 10 (PND10) and PND21 after single gavage (0.05 mg/kg b.w.). Dose- and time-dependent responses in bacterial recovery/microbial composition were observed in adults after a single gavage. Repeated exposure caused a transient decrease in the recovery of intestinal bacteria, a shift in the bacterial population with abundance of arsenic resistance genes, and evidence for host metabolism of arsenite into less-reactive trivalent methylated species. Arsenic exposure in adult animals induced high levels of CC chemokines and of proinflammatory and anti-inflammatory cytokine secretion in intestine. Arsenic exposure at PND21 resulted in the development of distinct bacterial populations. Results of this study highlight significant changes in the intestinal microbiome and gut-associated immune status during a single or repeated exposure to arsenic in juvenile and adult animals. The data warrant investigation of the long-term effects of oral arsenic exposure on the microbiome and of immune system development and responses. Transformation of organic arsenic to toxic inorganic arsenic (iAs) is likely carried out by intestinal bacteria, and iAs may alter the viability of certain microbial populations. This study addressed the impact of arsenic exposure on intestinal microbiota diversity and host gut-associated immune mediators during early development or adulthood using scenarios of acute or repeated doses. During acute arsenic exposure, animals developed defense functions characterized by higher abundances of bacteria that are involved in arsenic resistance or detoxification mechanisms. Arsenite had a negative effect on the abundance of bacterial species that are involved in the conversion of protein to butyrate, which is an alternative energy source in the intestine. The intestinal mucosal immune cytokine profile reflected a mechanism of protection from arsenic toxicity.

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Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study

Cited by 7 publications

References 29 publications

Tetra-arsenic tetra-sulfide ameliorates lupus syndromes by inhibiting IL-17 producing double negative T cells

Tetra-arsenic tetra-sulfide ameliorates lupus syndromes by inhibiting IL-17 producing double negative T cells

Progress in traditional Chinese medicine and natural extracts for the treatment of lupus nephritis

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

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