Effects of tetracycline on growth, oxidative stress response, and metabolite pattern of ryegrass

Han, Tao; Liang, Yueping; Wu, Zhenzhen; Zhang, Li; Liu, Zhenwei; Li, Qingfei; Chen, Xuejin; Guo, Wei-Li; Jiang, Lina; Pan, Feifei; Ge, Shaohua; Mi, Zhaorong; Zun-chun, Liu; Huang, Hongjuan; Li, Xinzheng; Zhou, Junguo; Li, Yang; Wang, Jialiang; Zhang, Zhen; Tang, Yingying; Yang, Linru; Wu, Mengdan

doi:10.1016/j.jhazmat.2019.120885

Cited by 101 publications

(21 citation statements)

References 56 publications

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“…Chi et al (2010) found that OTC can interact with a binding site of CAT through van der Waals interaction and hydrogen bonding, and the microenvironment of tryptophan residues and the secondary structure of CAT change after combining with OTC. Other studies have reported that the CAT activity of ryegrass and maize decreased under tetracyclines stress which con rmed our result (Cui and Zhao, 2011;Han et al, 2019).…”

Section: Discussionsupporting

confidence: 92%

Toxicity of chlortetracycline and oxytetracycline on Vallisneria natans (Lour.) Hare

Yang

2021

Environ Sci Pollut Res

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Tetracyclines are frequently detected in water bodies due to their widespread use in aquaculture and animal husbandry. A hydroponic experiment was conducted to explore the phytotoxic effects of Vallisneria natans (Lour.) Hare exposed to various concentrations of chlortetracycline (CTC) and oxytetracycline (OTC) (0, 0.1, 1, 10, 30, 50 and 100 mg/L) for 7 days (7 D) and 14 days (14 D), respectively. The results showed that similar to OTC treatment for 7 D, the relative growth rates (RGR) and catalase (CAT) activity of V. natans , after 7 D of CTC exposure, decreased signi cantly at 10 mg/L and 30 mg/L, respectively. The content of soluble protein notably decreased when CTC ≥ 10mg/L and OTC ≥ 30mg/L. The hydrogen peroxide (H 2 O 2 ) content was signi cantly stimulated when OTC ≥ 10mg/L, while it hardly changed when exposed to CTC. After 14 D, the malondialdehyde (MDA) and H 2 O 2 contents of V. natans were signi cantly higher than those of the control group under high concentration of OTC (≥ 30mg/L), but they didn't change signi cantly under high concentration of CTC. The activity of polyphenol oxidase (PPO), under CTC treatment after 14 D, showed rst a signi cant increase then decrease, the maximum value (125% of the control) was notice at 10 mg/L CTC, while it remained unchanged when exposed to OTC. The soluble protein content signi cantly decreased at 10 mg/L CTC and 0.1 mg/L OTC, respectively. The RGR, CAT and peroxidase (POD) activities, similar to OTC treatment after 14 D, decreased evidently when CTC was 10 mg/L, 30 mg/L and 0.1 mg/L, respectively. CTC and OTC harm the chlorophyll content of V. natans after 14 D, and the reduction of chlorophyll a and carotenoid were more pronounced than chlorophyll b. The results suggest that CTC and OTC both have negative effect on the growth of V. natans , and OTC can cause oxidative damage in V. natans but CTC harm the metabolism process without inducing oxidative damage. Overall, the toxicity of OTC to V. natans is stronger than that of CTC.

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Section: Discussionsupporting

confidence: 92%

Toxicity of chlortetracycline and oxytetracycline on Vallisneria natans (Lour.) Hare

Yang

2021

Environ Sci Pollut Res

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“…As a branched-chain amino acid, valine can scavenge the generated reactive oxygen species (ROS; Hu et al, 2015 ). In addition, it is directly and indirectly involved in many important metabolic functions, including aminoacyl-tRNAs biosynthesis, which is part of the protein synthesis mechanism ( Ling et al, 2009 ; Han et al, 2019 ). Aromatic amino acids are precursors for the synthesis of flavonoids, and their enhanced synthesis will increase the protein content ( Kreft et al, 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Physiological Responses and Metabonomics Analysis of Male and Female Sargassum thunbergii Macroalgae Exposed to Ultraviolet-B Stress

et al. 2022

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Ultraviolet-B (UV-B) radiation is a major environmental stress that suppresses or activates defense responses in organisms. UV-B radiation affecting growth and development in intertidal species have been researched for a long time, but a series of unknown knowledge remain in the male and female macroalgae comparison. To compare the different responses of male and female Sargassum thunbergii macroalgae under UV-B radiation, PSII photochemical efficiency determination, metabolomic analysis, and main carbon-based metabolites (including soluble sugar, total amino acid, and lipid) content measuring have been performed in our experiments. Results showed that males have significantly superiority performance in the chlorophyll fluorescence parameters of Fv/Fm, Y(II), and Y(NO) either low or high UV-B radiation treatments. Metabolomics analysis revealed that carbon and nitrogen metabolism pathways in male and female S. thunbergii were significant components responding to enhanced UV-B radiation. Based on measuring, female S. thunbergii lipid content expressed higher than males without any stimulation. Additionally, under low UV-B radiation stimulation, females total amino acid content shown significantly higher than control group and their lipid content also significantly higher than males. Under high UV-B radiation, males soluble sugar, total amino acid, and lipid content significantly varied from females, which meant that enhancing UV-B stress might altered mainly carbon-based metabolites flowing directions. The present study elucidated the potential role of enhanced UV-B radiation in regulating macroalgae physiological responses, metabolites changing, and reflecting differences between male and female S. thunbergii, contributing to understanding of brown-macroalgae diecious adopting mechanisms in defending intertidal UV-B stresses.

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“…Its toxicity is hundreds of times higher than that of other veterinary antibiotics such as sulfamethazine [6]. Although pharmaceutical residues are only the subject of a watch list, the very low biodegradability of CTC makes it viewed as a significant environmental pollutant [7,8]. Chlortetracycline has been detected in different aquatic environments, such as surface water (122.3 ng L − 1 ) and ground water (86.6 ng L − 1 ) [9].…”

Section: Introductionmentioning

confidence: 99%

Nickel foam as a new material for chlortetracycline electrochemical oxidation: Biodegradability improvement and biological treatment

Saidi

Fourcade

Bellakhal

et al. 2020

Journal of Electroanalytical Chemistry

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Chlortetracycline CTC is an organochlorine compound released from industrial pharmaceutical waste. This pollutant had dangerous effects in aquatic organisms and human health, since it is responsible for inhibition of microbial activity and growth. In this study, the elimination of CTC from water is A c c e p t e d m a n u s c r i p t targeted. Biodegradability, based on the BOD 5 / COD ratio was studied, showing the non-feasibility of a direct biological treatment. Cyclic voltammetry analysis on a nickel electrode revealed a significant electrochemical activity of CTC. An electrochemical pre-treatment was therefore carried out in a percolation cell using a nickel foam as a working electrode at the potential of 0.5 V /SCE. The operating parameters were optimized. A degradation yield of 99% was achieved for an initial concentration of pollutant of 50 mg L-1 and a flow rate of 5 mL min-1 in alkaline conditions. After electrolysis, a total dechlorination of CTC was observed. The biodegradability ratio was improved, from 0.13 to 0.33 after electrolysis; while the dissolved organic carbon (DOC) analysis revealed that the level of mineralization remained low 27%. A 21 days biological treatment with activated sludge was then carried out, leading to an overall mineralization yield of 78%.

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Effects of tetracycline on growth, oxidative stress response, and metabolite pattern of ryegrass

Cited by 101 publications

References 56 publications

Toxicity of chlortetracycline and oxytetracycline on Vallisneria natans (Lour.) Hare

Toxicity of chlortetracycline and oxytetracycline on Vallisneria natans (Lour.) Hare

Physiological Responses and Metabonomics Analysis of Male and Female Sargassum thunbergii Macroalgae Exposed to Ultraviolet-B Stress

Nickel foam as a new material for chlortetracycline electrochemical oxidation: Biodegradability improvement and biological treatment

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