Effects of the 5-HT&lt;sub&gt;1A&lt;/sub&gt; Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats

Tsutsui, Ryuki; Shinomiya, Kazuaki; Sendo, Toshiaki; Kitamura, Yoshihisa; Kamei, Chiaki

doi:10.1248/bpb.b14-00887

Cited by 13 publications

(3 citation statements)

References 33 publications

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“…In intact cats, ACTH infusions suppressed REM sleep (Koranyi et al, 1971) and, in rats, it significantly increased sleep latency and wake time while decreasing NREM sleep time (Tsutsui et al, 2015). Since sleep disturbances in depressive patients are characterized by an increase in sleep latency and a decrease in NREM sleep time (Holshoe, 2009), it has been proposed that chronic administration of ACTH in rats might represent a valid animal model for human depression (Tsutsui et al, 2015) (Table 2).…”

Section: Acthmentioning

confidence: 99%

Stress & sleep: A relationship lasting a lifetime

Martire

Caruso

Palagini

et al. 2020

Neuroscience & Biobehavioral Reviews

155

108

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Section: Acthmentioning

confidence: 99%

Stress & sleep: A relationship lasting a lifetime

Martire

Caruso

Palagini

et al. 2020

Neuroscience & Biobehavioral Reviews

155

108

View full text Add to dashboard Cite

“…To perform this study, healthy male Wistar rats that weight between 250 and 350 g were selected, none of which showed abnormal motor behavior by rotarod test. Rats had free access to food and water, they were single housed and kept in a 12:12 light-dark cycle at a temperature-controlled room; to avoid bias caused by the circadian cycle of rats, DBS was performed at night 20 . The entire management of animals was done according to the Mexican Official Norm NOM-062-ZOO-1999.…”

Section: Subjectsmentioning

confidence: 99%

Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats

Flores-Vargas

Campos-García-Rojas

Jiménez-Ponce

2019

HGMX

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Introduction: Different rodent models of obsessive-compulsive disorder (OCD) have been used with the purpose for understanding this mental disease; in a previous article, we described quinpirole (QP) as a dopaminergic inductor of perseverative behavior. Objective: The objective of this study was to evaluate the decrease of QP-induced perseverative behavior observed in an open field after unilateral deep brain stimulation-low frequency (DBS-LF) into the orbitofrontal cortex (OFC) in Wistar rats. Materials and Methods: A total of 40 adult male Wistar rats were divided into three groups, each group underwent pharmacological treatment: sodium chloride (NaCl), QP, and clomipramine (CMP), these groups were not implanted with an electrode. An additional group was implanted into OFC Sham (SH), and after behavior evaluation, unilateral DBS-LF (6 Hz) was applied during night time for 5 min each side; first left side and after right side. Results: Distance traveled significantly decreased in the 5 min observed between QP and NaCl (p = 0.016), and a significant difference was found between NaCl and SH (p = 0.020). There was no significant difference between NaCl and CMP (p = 0.582) or NaCl and DBS-LF (p = 0.829). No significant difference between DBS left side and right side was found (p = 1.00). Conclusions: Unilateral DBS of the OFC prevents perseverative behavior in an open field, induced by QP.

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“…Primarily, antidepressants such as tricyclic antidepressants with anticholinergic activity may induce severe intestinal dysfunction and delirium, while monotherapy of tandospirone significantly ameliorated the depressive mood, agitation and anxiety of senile patients with dementia with little anticholinergic activity [ 65 ]. Secondly, eighty to ninety percent of patients with major depression are suffering from sleep disturbance, which is widely accepted as a risk factor and/or prodromal symptom of depression [ 66 – 69 ], while tandospirone could markedly improve sleep disturbance induced by Adrenocorticotropic hormone (ACTH) in a rat model [ 70 ]. Finally, since SSRIs are still the first choice for the treatment of patients with depression, the side effect of SSRIs could not be ignored.…”

Section: Tandospirone In the Treatment Of Cns Disordersmentioning

confidence: 99%

Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms

Huang

Yang

et al. 2017

Oncotarget

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5-hydroxytryptamine (5-HT, serotonin) is an important neurotransmitter in the modulation of the cognitive, behavioral and psychological functions in animals and humans. Among the fourteen subtypes of 5-HT receptor, 5-HT1A receptor has been extensively studied. Tandospirone, an azapirone derivative with strong and selective agonist effect on 5-HT1A receptor, has been used for the treatment of anxiety disorders especially generalized anxiety disorder for decades. Recently, tandospirone showed the efficacy in relieving the syndromes of social anxiety disorder and post-traumatic stress disorder as well as in potentiating the effect of antidepressants in the treatment of depression in both preclinical and clinical studies. More impressively, the beneficial effect of tandospirone has been revealed on improvement of motor dysfunction of Parkinson's disease and cognitive deficits of schizophrenia either in monotherapy or in combination with other drugs. This review discusses the superiority of tandospirone in the treatment of the disorders and associated mechanisms in central nervous system from the literature.

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Effects of the 5-HT<sub>1A</sub> Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats

Abstract: The aim of this study was to compare the effect of the serotonin (5-HT) 1A

Cited by 13 publications

References 33 publications

Stress & sleep: A relationship lasting a lifetime

Stress & sleep: A relationship lasting a lifetime

Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats

Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms

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