Effects of the 52% low-sodium salt applied to CM-DASH diet in hypertensive patients with type 2 diabetes：A Randomized Controlled Trial

Abstract

Background and Aims: The DASH diet have been proven to be effective in lowering blood pressure (BP), but it is rarely used in people with type 2 diabetes (T2D), especially in the Chinese population. We aimed to evaluate the effects of 52% low- sodium salt applied to CM-DASH diet in patients with hypertension and T2D. Methods and Results: This trial is a single-blind, randomized controlled study conducted from December 2019 to November 2020 at Chongqing, China. 61 participants were randomly allocated to intervention group or control group for 8 weeks.2 participants were lost, and 59 patients were finally included in the analysis. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of intervention group and control group were significantly decreased compared with baseline, but there was no difference between groups. The 24-hour urine Na+ and Cl- of the two groups decreased significantly after intervention, but the increase of 24-hour urine K+ and the decrease of Na+/ K+ ratio were only observed in the intervention group. Furthermore,the urine urinary albumin creatinine ratio (UACR) and serum creatinine of two groups also decreased from baseline. Conclusions: Following the CM-DASH diet in hypertensive patients with T2D has beneficial effects in improving SBP and DBP. and the application of 52% low-sodium salt has a significant effect in reducing sodium intake and increasing potassium intake.