2023
DOI: 10.4149/gpb_2023010
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Effects of the acute administration of delta-opioid receptor ligands on the excitability of rat hippocampal glutamate and brainstem monoamine neurons in vivo

Abstract: It was previously reported that the delta opioid receptor (DOR) agonist SNC80 and antagonist naltrindole modulate the excitability of hippocampal glutamate neurons in primary cultures. The present study aimed to investigate the acute effects of these ligands on the firing activity of hippocampal cornu ammonis 1/3 (CA1/3) glutamate, dorsal raphe nucleus (DRN) serotonin (5-HT), locus coeruleus (LC) noradrenaline, and ventral tegmental area (VTA) dopamine neurons in in vivo conditions. Adult Wistar male rats were… Show more

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Cited by 2 publications
(4 citation statements)
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“…In agreement with our previous results (Csatlosova et al, 2021) there were no sex differences in the firing activity of 5-HT neurons. The characteristics of the firing activity of hippocampal glutamate and brainstem 5-HT and dopamine neurons in offspring of the control dams were similar to those observed in control animals in our previous studies without any behavioral testing (Grinchii et al, 2022;Grinchii et al, 2023). Even though in the present study behavioral tests were performed on the same animals before electrophysiological recordings, they are unlikely to affect the firing activity of the neurons.…”
Section: Discussionsupporting
confidence: 85%
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“…In agreement with our previous results (Csatlosova et al, 2021) there were no sex differences in the firing activity of 5-HT neurons. The characteristics of the firing activity of hippocampal glutamate and brainstem 5-HT and dopamine neurons in offspring of the control dams were similar to those observed in control animals in our previous studies without any behavioral testing (Grinchii et al, 2022;Grinchii et al, 2023). Even though in the present study behavioral tests were performed on the same animals before electrophysiological recordings, they are unlikely to affect the firing activity of the neurons.…”
Section: Discussionsupporting
confidence: 85%
“…There were 11 dams in each treatment group. The dose of SNC80 has been selected according to our previous dose-response study ( Grinchii et al, 2023 ). Similarly, the period of gestation was chosen according to previous experiments with antidepressant drug treatments during gestation ( Viñas-Noguera et al, 2022 ; Grinchii et al, 2024 ).…”
Section: Methodsmentioning
confidence: 99%
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