Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

Ito, Chihiro; Shen, Haowei; Toyota, Hiroshi; Kubota, Yasuhiko; Sakurai, Eiko; Watanabe, Takehiko; Sato, Mitsumoto

doi:10.1016/s0304-3940(99)00052-x

Cited by 46 publications

(22 citation statements)

References 19 publications

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“…It is noteworthy that the low expressing levels of this subtype in the major motor centers such as the striatum and cortex of the hamster treated with 3-NP seem to fit very nicely with the low levels of H 1 R in AD patients (Higuchi et al, 2000) and accelerated kindling seizures (Chen et al, 2003). On the other hand, high expression levels of H 3 R, especially in amygdalar areas as well as the cortex layers of the hamster treated with 3-NP, appear to be consistent with species-specific responses as shown by an up-regulation of this subtype in striatum of stressed rats (Ito et al, 1999) as compared with a down-regulation in diencephalic areas of other pathological states such as status epilepticus in the rat (Jin et al, 2005). Moreover, even environmental-related stressful conditions tend to play a determinant role on the transcriptional activity of this subtype as confirmed by the varying photoperiodic effects accounting for a down-regulating trend of H 3 R mRNA levels in the same brain region of another species, the Siberian hamster (Barrett et al, 2005).…”

Section: Discussionsupporting

confidence: 63%

The Histaminergic Signaling System Exerts a Neuroprotective Role against Neurodegenerative-Induced Processes in the Hamster

Canonaco

Madeo²,

Alò³

et al. 2005

J Pharmacol Exp Ther

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The neurotoxic 3-nitropropionic acid (3-NP), a freckled milk vetch-derived inhibitor of mitochondrial enzymatic processes that is capable of mimicking the typical pathological features of neurodegenerative disorders, behaved in a differentiated manner in a hibernating rodent (hamster) with respect to a nonhibernating rodent (rat). Treatment of the two rodents with both an acute and chronic 3-NP dose supplied deleterious neuronal effects due to distinct histamine receptor (H n R) transcriptional activities, especially in the case of the rat. In hamsters, these treatment modalities accounted for overall reduced global activity in a freely moving environment and overt motor symptoms such as hindlimb dystonia and clasping with respect to the greater abnormal motor behaviors in rats. This behavioral difference appeared to be strongly related to qualitative fewer neuronal alterations and, namely, lesser crenated cell membranes, swollen mitochondria, and darkened nuclei in hamster brain areas. Moreover, a mixed H 1,3 R mRNA expression pattern was reported for both rodents treated with a chronic 3-NP dose as demonstrated by predominantly low H 1 R mRNA levels (Ͼ50%) in rat striatum and cortex, whereas extremely high H 3 R levels (Ͼ80%) characterized the lateral and central amygdala nuclei plus the striatum of hamsters. Interestingly, the H 3 R antagonist (thioperamide) blocked 3-NP-dependent behaviors plus induced an up-regulation of H 1 R levels in mainly the above-reported hamster amygdalar nuclei. Overall, these results show, for the first time, that a major protective role against neurodegenerative events appears to be strongly related to the expression activity of H 1,3 R subtypes of amygdalar neurons in this hibernating model.

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Section: Discussionsupporting

confidence: 63%

The Histaminergic Signaling System Exerts a Neuroprotective Role against Neurodegenerative-Induced Processes in the Hamster

Canonaco

Madeo²,

Alò³

et al. 2005

J Pharmacol Exp Ther

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“…40,49 It is, furthermore, known that histamine has various physiological roles as a neurotransmitter in the brain and that in the histaminergic neuronal system three different receptors exist: 50 postsynaptic histamine H1 and H2 as well as presynaptic H3. Histamine turnover in the diencephalon has been suggested to be related to the pathology of the depressive state by Ito et al 51 and histamine H3 receptor antagonists have been shown to possess antidepressive effects. 50 Furthermore, H1 receptor antagonists, commonly called antihistamines, also have (a) immunological effects since they inhibit the immediate wheal and flare response to intradermal allergens 37 and (b) psychological effects, for they are known to decrease the anxiety state of a person.…”

Section: Discussionmentioning

confidence: 99%

Atopy and depression: results from the Northern Finland 1966 Birth Cohort Study

et al. 2003

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Several studies have suggested an association between IgE-mediated atopic allergies and depression. The present study extends our understanding about putative gender differences of this association and provides further epidemiological evidence for our previous finding that the association between atopy and depression may be characteristic for females only. In order to clearly determine the presence of atopic disorders and depression, we used more valid tools than had been employed earlier and we had access to a database (the Northern Finland 1966 Birth Cohort), in which individuals were followed up prospectively until the age of 31 years. The information on allergic symptoms, verified by skin-prick tests and comprising data of 5518 individuals, was used to ascertain the presence of atopy. Depression was assessed with the help of Hopkins' Symptom Checklist-25 and self-reported doctor-diagnosed depression. After adjusting for a father's social class, mother's parity, and place of residence, logistic regression analyses showed that the risk of developing depression increased in parallel with the increasing severity of depression and, when compared with nonatopic subjects, was 3.0 to 4.7-fold up in atopic females and statistically significant. In atopic males, the association between atopy and depression was statistically significant only in the highest depression scores, the odds ratio being 6.3-fold. The results indicate that females suffering from atopic diseases might possess an elevated risk of developing depression already during early adulthood. In males, the association between these two disorders is evident only among the most severe manifestations of depression. Possible background theories, that is, genetic abnormalities in serotonin metabolism, HPA-axis dysfunction, and histamine theory are discussed.

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“…In another study, the intraventricular administration of histamine caused an increase in the hypothalamic levels of tritiated histamine and a dose-dependent inhibition in avoidance conditioning in rats (26). Histamine levels were also shown to be significantly higher in the diencephalon of rats submitted to acute stress by confinement in a tight cage for 1 h (27).…”

Section: Discussionmentioning

confidence: 90%

L-histidine reduces inhibitory avoidance in Carassius auratus submitted to cerebellar ablation

Garção

Mattioli

2009

Braz J Med Biol Res

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The effect of post-training treatment with L-histidine (LH) on the memory consolidation of inhibitory avoidance was investigated in Carassius auratus submitted to cerebellar ablation. The inhibitory avoidance procedure included 3 days: one habituation day, one training day (5 trials, T1-T5) and one test day. On the training day, each fish was placed individually in a white compartment separated from a black compartment by a sliding door. When the fish crossed into the black compartment, a weight was dropped in front of it (aversive stimulus) and the time to cross was recorded. Saline or LH (100 mg/kg) was injected intraperitoneally 10 min after the trials. Data were log 10 transformed and analyzed by ANOVA and the Student-Newman-Keuls test (P < 0.

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Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

Cited by 46 publications

References 19 publications

The Histaminergic Signaling System Exerts a Neuroprotective Role against Neurodegenerative-Induced Processes in the Hamster

The Histaminergic Signaling System Exerts a Neuroprotective Role against Neurodegenerative-Induced Processes in the Hamster

Atopy and depression: results from the Northern Finland 1966 Birth Cohort Study

L-histidine reduces inhibitory avoidance in Carassius auratus submitted to cerebellar ablation

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