2024
DOI: 10.21203/rs.3.rs-3809589/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Effects of the AMPAr antagonist, Perampanel, on Cognitive Function in Rats Exposed to Neonatal Iron Overload

José Afonso Corrêa Silva,
Lariza Oliveira Souza,
Maria Paula Arakaki Severo
et al.

Abstract: Iron accumulation has been associated with the pathogenesis of neurodegenerative diseases and memory decline. As previously described by our research group, iron overload in the neonatal period induces persistent memory deficits, increases oxidative stress, and apoptotic markers. The neuronal insult caused by iron excess generates an energetic imbalance that can alter glutamate concentrations and thus trigger excitotoxicity. Drugs that block glutamatergic receptor, eligibly mitigate neurotoxicity; among them, … Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 55 publications
(63 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?