Effects of the ancillary ligands of polypyridyl cobalt(II) complexes on pH-induced spectral properties and DNA binding properties

Huang, Xiaoning; Zhu, Wen T.; Zhang, Jia C.; Su, Guo

doi:10.1007/s00706-011-0624-1

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…The connection bond to the imidazo [4,5-f] [1,10]phenanthroline ring system at the ortho (2-) position was drawn in bold for clarity. References are pip, [15,26,58] mcmip, [21,69] bfiph, [70] pnip, [67] ipbd, [63] fpp, [7] cpiph, [8] fyip, [66] qip, [6] pyip, [15,71] hnaip [1,24,40] ciip [16,46] bdip [13,72] nip [37,73] phimiphen, [10] aip. [15] The compounds of interest btdip and dbfip are shown in the black square at the end.…”

Section: Introductionmentioning

confidence: 99%

DNA Interactions and Antiproliferative Activity Studies of Octahedral Nickel Complexes of Two Extended Phenanthrolines

et al. 2021

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Two new imidazophenanthroline derivatives, namely 2-(4bromo-(2,1,3)-benzothiadiazol-7-yl)-1H-imidazo [4,5- [1,10]phenanthroline (dbfip) and their octahedral nickel complexes [Ni(phen) 2 (btdip)] 2 + (1) and [Ni(phen) 2 (dbfip)] 2 + (2) have been synthesized and characterized by CHN analysis, ESI-MS, NMR and UV-vis spectra. Their DNA binding abilities were spectrophotometrically, hydrodynamically and electrophoretically studied and found that while btdip binds DNA externally, dbfip binds in the grooves and both of their nickel complexes also bind DNA through grooves giving severe DNA damage in the presence of peroxide. The compounds were screened against four different human cancer cell lines using MTT assay method. The results obtained showed that both ligands are active against DLD-1, and further dbfip is found to be more active than positive control drugs against DLD-1 and HepG2 cell lines. The complex 2 has more antiproliferative effect than 1 against MCF-7 and HepG2 cells. On the other hand, complex 2 was found to have more toxic effect on HepG2 cells than the standard drugs cisplatin and ploxal-S.

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