Effects of the antipsychotic quetiapine on sleep and breathing: a review of clinical findings and potential mechanisms

Fauska, Cricket; Bastiampillai, Tarun; Adams, Robert J.; Wittert, Gary; Eckert, Danny J.; Loffler, Kelly A.

doi:10.1111/jsr.14051

Cited by 2 publications

(2 citation statements)

References 79 publications

(128 reference statements)

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Section: Introductionmentioning

confidence: 99%

“…2,3 These factors can lead to a myriad of acute cardiovascular consequences. 4 Atrial Fibrillation (AF) is the most common type of clinically significant cardiac arrhythmia 5 and is associated with an increased risk of cardiovascular hospitalization and all-cause mortality, especially in women. 6 Atrial Fibrillation (AF) is the most common type of clinically significant cardiac arrhythmia 5 and is associated with an increased risk of cardiovascular hospitalization and all-cause mortality, especially in women.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Obstructive Sleep Apnea Among Atrial Fibrillation Patients: A Cross-Sectional Study from Jordan

Ibdah,

Zaitoun,

Altawalbeh

et al. 2024

JMDH

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Background Obstructive Sleep Apnea (OSA) is a common respiratory disorder that causes intermittent upper airway collapse during sleep and can lead to various acute cardiovascular complications. Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of cardiovascular hospitalization and all-cause mortality. Our study aimed to investigate the prevalence of individuals with AF and those considered at high risk for OSA. Methods A cross-sectional study was conducted with a population comprising patients who had visited KAUH cardiology clinics between 2017–2019; subjects were categorized into AF patients and general cardiology patients. Patients were surveyed for OSA using the Berlin Questionnaire to assess the degree of OSA symptoms and to classify patients into high- or low-risk groups based on their responses. Results Of the 656 patients, 545 met our inclusion criteria, of whom 192 were diagnosed with AF. Comparable demographic characteristics were observed between the AF and non-AF groups, barring higher rates of obesity ( p =0.001) and smoking ( p =0.042) in the AF group. The prevalence of high-risk OSA was significantly higher in AF patients (68.2%) compared to non-AF patients (29.4%), with an adjusted odds ratio of 2.473 times (95% CI: 1.434 −4.266, p =0.001) greater for AF. The age, gender, and BMI categories did not differ significantly between the two groups. Binary logistic regression revealed significant associations between OSA and risk factors such as asthma (OR=4.408, 95% CI: 2.634–7.376, p=0.001). Conclusion These results serve to display a statistically significant increase in high-risk OSA in existing AF patients, irrespective of the presence of conventional OSA risk factors; this could imply a more immediate and direct relationship between both diseases and calls to include routine screening for OSA in patients diagnosed, newly or otherwise, with AF.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of Obstructive Sleep Apnea Among Atrial Fibrillation Patients: A Cross-Sectional Study from Jordan

Ibdah,

Zaitoun,

Altawalbeh

et al. 2024

JMDH

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Model-informed precision dosing of quetiapine in bipolar affective disorder patients: initial dose recommendation

Zheng,

Jin,

Yin

et al. 2024

Front. Psychiatry

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ObjectiveBipolar affective disorder (BAD) is a mood disorder with high morbidity and mortality. Quetiapine can be used in the treatment of patients with BAD; however, the precise administration regimen of quetiapine in these patients is still unknown. In this study, a population pharmacokinetic (PPK) model of quetiapine in patients with BAD was constructed based on model-informed precision dosing (MIPD) and real-world clinical data and an optimal initial dose of quetiapine in these patients was recommended.MethodsA total of 99 patients with BAD treated with quetiapine were included. At the same time, the quetiapine concentrations, the physical and chemical indices of the patients, and the drug combination information were collected. A quetiapine PPK model for patients with BAD was then constructed and an initial dose based on Monte Carlo simulation was recommended.ResultsIn the final model of quetiapine for patients with BAD, the apparent oral clearance (CL/F) and the apparent volume of distribution (V/F) were 76.1 L/h and 530 L, respectively. For patients with BAD weighing 40–66 kg, the initial dose recommendation was 16 mg kg−1 day−1, the probability of reaching the therapeutic window was 78.8%–82.2%, and the probability of exceeding the upper limit of the therapeutic window was 5.2%–10.3%. For patients with BAD weighing 66–120 kg, the initial dose recommendation was 12 mg kg−1 day−1, the probability of reaching the therapeutic window was 81.5%–85.5%, and the probability of exceeding the upper limit of the therapeutic window was 3.6%–8.1%.ConclusionThe present study, for the first time, recommended an initial dose of quetiapine in patients with BAD based on MIPD and real-world data, providing an individualized reference for the administration of quetiapine in these patients.

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Effects of the antipsychotic quetiapine on sleep and breathing: a review of clinical findings and potential mechanisms

Cited by 2 publications

References 79 publications

Prevalence of Obstructive Sleep Apnea Among Atrial Fibrillation Patients: A Cross-Sectional Study from Jordan

Prevalence of Obstructive Sleep Apnea Among Atrial Fibrillation Patients: A Cross-Sectional Study from Jordan

Model-informed precision dosing of quetiapine in bipolar affective disorder patients: initial dose recommendation

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