Effects of the Application of High-Pressure Oxygen on the Treatment of Periodontal Disease in Diabetic Patients

Abstract

SUMMARYPurpose. In this study we wanted to observe the improvement in the healing of periodontal tissues in a group of diabetic patients treated with traditional methods compared to another group treated with the addition of oxygen. The potential of oxygen has long been known in the field of plastic surgery, where it is used to treat burns and skin lesions. Materials and methods. This study consists in a split mouth study which involved 30 patients. We carefully treated them with periodontal therapy using manual and mechanical instrumentation. Then, we applied oxygen in half mouth according to randomization list. Finally we checked up patients after some weeks. Results. Our results highlight that all areas treated with oxygen application healed more rapidly and better than no treated areas. Conclusions. All in all, we have demonstrated that oxygen can improve the outcome of non-surgical periodontal treatment in diabetic subjects.

A therapeutic oxygen carrier isolated from Arenicola marina decreased P. gingivalis induced inflammation and tissue destruction

“…Bacterial persistence in the periodontal pockets leads to an accumulation of inflammatory cell infiltrate and consequent high proteolytic enzymes' content that can hinder the periodontal regenerative process by destabilizing the clot and formation of long junctional epithelium. The beneficial effects of M101 on EC in the periodontium would be explained by M101's note-worthy oxygenation capacity in wound environments and periodontal pockets where oxygen improves vascularization and counteracts infection and edema, leading to improved wound healing and regenerative response 82,83 . Nonetheless, the underlying pathways impacted by M101 should be further explored.…”

Small Extracellular Vesicles Laden Oxygen-Releasing Thermosensitive Hydrogel for Enhanced Antibacterial Therapy against Anaerobe-Induced Periodontitis Alveolar Bone Defect

“…Adequate oxygenation is considered as a potential treatment strategy for damage repair by providing large amounts of energy, as it counters infection principally caused by anaerobic bacteria, facilitates angiogenesis, and promotes collagen synthesis and cell proliferation. − Thus, in situ conserving oxygen concentration inside the periodontal pockets with an effective delivery system would be a potential strategy to remove the hypoxia microenvironment. Also, oxygen could support the production of bactericidal oxygen free radicals mediated by immune cells under physiological conditions to improve the innate defense mechanism of the body against bacterial invasion .…”