Effects of the application of Aloe vera (L.) and microcurrent on the healing of wounds surgically induced in Wistar rats

Mendonça, Fernanda Aparecida Sampaio; Passarini, José Roberto; Esquisatto, Marcelo Augusto Marretto; Mendonça, Josué Sampaio; Franchini, Cristina Cruz; Santos, Gláucia Maria Tech dos

doi:10.1590/s0102-86502009000200013

Cited by 69 publications

(64 citation statements)

References 20 publications

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“…Ellagitannin or ellagic acid can help the precipitation of proteins in damaged tissues, so it can provide the scabs formation rapidly. This activity will also reduce the edema and exudative fluids on wound surface through decreasing of capillaries permeability [20,24]. Beside that activity, other activities are thought to play a role in wound healing process from its ability as an angiogenic agent [25].…”

Section: Discussionmentioning

confidence: 99%

Ellagic Acid Activity in Healing Process of Incision Wound on Male Albino Rats (Rattus norvegicus)

Primarizky

Yuniarti

Lukiswanto

2017

KLS

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This study was conducted to prove whether ellagic acid can be used as a regulator of incision wound healing process in male albino rats as experimental animals. A total of 24 male healthy rats based on physical examination, aged at 3 months old and weight at 150-180 grams used in this study. Rats were divided into three groups and each group has 8 replications, group of control (P0) has no incision wound and no medication, treatment group (P1) has incision wound and treated with Betadine® and (P2) has incision wound and treated with 2,5 % ellagic acid. The variable that observed are histopathology changes (collagen, PMN, angiogenesis and fibrosis) from the male albino rats. The samples collection was taken at day 15 and data were collected and analyzed by Analysis of Variance (ANOVA) test. The result of collagen and PMN cells score in the control group (P0) were 1.80 ± 0.16 and 1.6 ± 0.08 with mild angiogenesis and no fibrosis. The results in the treatment (P2) group, where the collagen and PMN scores were 1.60 ± 0.08 and 1.5 ± 0.8, accompanied by mild angiogenesis and fibrosis. Meanwhile, in the treatment (P1) group, the results of scoring of collagen and PMN were lower than the other groups, 0, 80 ± 0.08 and 0.6 ± 0.16 accompanied by moderate angiogenesis and fibrosis. There was a significant difference of collagen scoring, PMN cells number, fibrosis and angiogenesis among the treatment groups (p<0.05). P1 treatment group has significant different with treatment groups P0 and P2 (p<0.05), but there is no significant difference between treatment groups P0 and P2 (p>0.05). From the results, it can be concluded that the topical application of ellagic acid ointment was proved to provide healing process on incision wound. Topical administration of ellagic acid ointment for 14 days was able to improve the skin condition and promoted the wound healing.

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Section: Discussionmentioning

confidence: 99%

Ellagic Acid Activity in Healing Process of Incision Wound on Male Albino Rats (Rattus norvegicus)

Primarizky

Yuniarti

Lukiswanto

2017

KLS

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“…Dorsal region was shaved and then antisepsis of region was done. Next, a full-thickness skin surgical incision measuring 20 mm in length and 2 mm in depth was made in the skin of the back of the animal in the caudocranial direction and incision was not sutured [10]. During postoperative days, animals remained in individual cages and isolated from their bedding through a metallic net to avoid wound infection.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Healing incisional surgical wounds using Rose Hip oil in rats

Cavalcante¹,

Pessoa²,

Júnior³

et al. 2017

int arch med

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“…Sabe-se que a combinação do gel de A. vera com ultrassom, microcorrente ou na forma de lipossomas pode acelerar a cicatrização e diminuir a inflamação ao favorecer a penetração dos ativos no tecido (Takahashi et al, 2009;Mendonça et al, 2009;Maia-Filho et al, 2011).…”

Section: Atividade Anti-inflamatória E Cicatrizanteunclassified

Propriedades farmacológicas da Aloe vera (L.) Burm. f.

Freitas¹,

Rodrigues

Gaspi

2014

Rev. bras. plantas med.

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RESUMO:A Aloe vera (L.) Burm.f. tem sido utilizada há milhares de anos na medicina tradicional para o tratamento de diversos males. O intuito desse trabalho foi o levantamento bibliográfico de artigos que evidenciassem a atividade farmacológica da Aloe vera. A revisão contemplou livros e periódicos nacionais e internacionais indexados nas bases de dados MEDLINE, LILACS e SciElo, nos idiomas português, inglês e espanhol, utilizando as palavras-chave citadas. Após o levantamento bibliográfico, constatou-se que várias atividades biológicas são atribuídas a Aloe vera. Evidências sugerem eficácia no tratamento da psoríase, herpes genital, queimaduras e hiperglicemia. Além disto, também foram demonstradas atividades antineoplásica, antimicrobiana, anti-inflamatória e imunomodulatória por estudos in vitro e in vivo, entretanto, na cicatrização de feridas, os resultados foram conflitantes. No tratamento de dermatite por radiação e em queimaduras solares sua eficácia não foi comprovada e foram relatados casos de hepatite aguda devido ao consumo de preparações orais. Tendo em vista as várias atividades comprovadas e poucos relatos acerca de sua contra indicação, conclui-se que o uso desta espécie corrobora o vasto uso popular. Palavras-chave:Aloe vera, babosa, fitoterapia, plantas medicinais.ABSTRACT: Pharmacological activities of Aloe vera (L.) Burm. f. The Aloe vera (L.) Burm.f. has been used for thousands of years in traditional medicine to treat various ailments. The aim of this study was to carry out a bibliographical review on the pharmacological activity of Aloe vera. This review included books and national and international journals indexed to MEDLINE, LILACS and SciELO, in Portuguese, English and Spanish, using the key words mentioned. After the literature review, we found that several biological activities have been attributed to Aloe vera. Evidence suggests efficacy in the treatment of psoriasis, genital herpes, burns and hyperglycemia. Moreover, antineoplastic, antimicrobial, anti-inflammatory and immunomodulatory activities have also been demonstrated by in vitro and in vivo studies; however, in wound healing, the results were conflicting. In the treatment of radiation dermatitis and sunburn, its efficacy has not been proven, and cases of acute hepatitis from the consumption of oral preparations have been reported. Considering the various proven activities and the few reports about the contraindications of Aloe vera, we conclude that the use of this species confirms its wide popular usage.

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Effects of the application of Aloe vera (L.) and microcurrent on the healing of wounds surgically induced in Wistar rats

Cited by 69 publications

References 20 publications

Ellagic Acid Activity in Healing Process of Incision Wound on Male Albino Rats (Rattus norvegicus)

Ellagic Acid Activity in Healing Process of Incision Wound on Male Albino Rats (Rattus norvegicus)

Healing incisional surgical wounds using Rose Hip oil in rats

Propriedades farmacológicas da Aloe vera (L.) Burm. f.

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