Effects of the Artemisia capillaris Extract on the Hepatotoxicity in Ethanol-induced Rats

Abstract

This study was conducted to find out the effects of aqueous extract from the leaves of Artemisia capillaris (AA) on the reduction of hepatotoxicity induced by ethanol in rats. In this experiment, Sprague Dawley rats were used in the experimental groups, which were divided into 5 groups; normal group, ethanol+UDCA (ursodeoxycholic acid)-treated group (positive control), ethanol-treated group (control), ethanol+Artemisia capillaris aqueous extract-treated group (200 mg/kg of BW) and ethanol+Artemisia capillaris aqueous extract-treated group (400 mg/kg of BW). AST (aspartate aminotransferase), ALT (alanine aminotransferase), GGT (gamma(γ)-glutamyl transferase) and LDH (lactate dehydrogenase) activities of the ethanol+Artemisia capillaris aqueous extract-treated group (400 mg/kg of BW) were significantly decreased compared to that of the ethanol-treated group (P<0.05). The triglyceride level of the ethanol-treated group was significantly increased and the HDL-cholesterol level was significantly decreased compared to the normal group (P<0.05). On the other hand, the triglyceride level was significantly decreased (P<0.05) and the HDL-cholesterol level was significantly increased (P<0.05) in the ethanol+Artemisia capillaris aqueous extract-treated groups. Superoxide dismutase (SOD) activity was enhanced significantly (P<0.05) in the ethanol+Artemisia capillaris aqueous extract-treated groups. Also, malondialdehyde contents were decreased in this group (P<0.05). Histologically, in the control group, there was a mild degenerative change around central venule. The AA treated group showed well preserved lobular architectures with no evidence of steatosis or liver damage in aqueous extract from the leaves of Artemisia capillaris treated group (H&E, ×20). As the results of this study, it is thought that Artemisia capillaris aqueous extract may have effects on the improvement of hepatic damage by ethanol.

Improving effect of Artemisiae Capillaris Herba extract in reflux esophagitis rats

“…인진호는 알칼리성 식품으로 칼륨, 칼슘, 철분 같은 무기질이 풍부하며, 비타민류, 정유류, alkaloids, flavonoid 등이 함유되어 있다 15) . 선행 연구로 간 기능 보호 16) , 항균 17) , 항암 18) , 항염증 15) , 항비만 19) , 항산화 (1.11 ± 0.38) 또한 대조군 사이에 유의성 있는 감소를 보였 다 (p<0.05) (Fig. 4).…”