Effects of the brominated flame retardant, TBCO, on development of zebrafish (Danio rerio) embryos

Essen, Darren Van; Devoy, Chloe; Miller, Justin G.P.; Jones, Paul D.; Wiseman, Steve

doi:10.1016/j.chemosphere.2020.129195

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…The effect of chemicals on swim bladder inflation in fish was reviewed by Dang et al (2021). Various chemicals affect swim bladder inflation in Japanese medaka and zebrafish, such as T3 (Godfrey et al, 2017, 2019), perfluorooctanesulfonic acid (Gaballah et al, 2020), PFBA (Godfrey et al, 2017; Godfrey et al, 2019), TDCPP (Godfrey et al, 2017, 2019), perfluorohexanesulfonic acid (Gaballah et al, 2020), 1,2,5,6‐tetrabromocyclooctane (Van Essen et al, 2021), triphenyltin (Horie et al, 2021), and pentabromobenzene (Peng et al, 2020). The results in the present study that PFBA and TDCPP exposure both induced non‐inflation of the swim bladder are consistent the findings from previous studies in Japanese medaka (Godfrey et al, 2019) and zebrafish (Godfrey et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish

Horie

Nomura

Okamoto

et al. 2022

J of Applied Toxicology

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We compared the influence of thyroid hormone-disrupting chemicals (heptafluorobutanoic acid, PFBA and tris[1, phosphate, TDCPP) and thyroid hormone (3,3 0 ,5-triiodo-L-thyronine, T3) on swim bladder inflation and thyroid hormone-related gene expression in Japanese medaka and zebrafish. The swim bladder of most larvae had inflated at 4 h post hatching (hph) in Japanese medaka and at 48 hph in zebrafish in controls. In both fish species, the swim bladder inflation was inhibited in larvae exposed to PFBA (lowest observed effect concentration [LOEC] in medaka: 40 mg/L; in zebrafish: 80 mg/L), TDCPP (LOEC in medaka: 1 mg/L; in zebrafish: 0.5 mg/L), and T3 (no inhibition in Japanese medaka; LOEC in zebrafish: 7.5 μg/L). We also examined the influence of PFBA, TDCPP, and T3 on the expression of thyroid stimulating hormone subunit beta (tshβ) or thyroid hormone receptor alpha (trα) and beta (trβ). No changes were observed in the expression of genes after PFBA and TDCPP exposure; however, T3 exposure upregulated trα and trβ expression in both fish species. When the results were compared between Japanese medaka and zebrafish, swim bladder inflation in both species was found to be inhibited by exposure to thyroid hormone-disrupting chemicals. Our results show that inhibition of the swim bladder inflation at 4 hph in Japanese medaka and 48 hph in zebrafish is a potential indicator of thyroid hormone-disturbing activity of chemicals.

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Section: Discussionmentioning

confidence: 99%

Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish

Horie

Nomura

Okamoto

et al. 2022

J of Applied Toxicology

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“…Changes in abundance of cyp1a transcript in embryos exposed to PAHs were determined relative to the DMSO control using the efficiency‐corrected method of Pfaffl (2001). Efficiency of the cyp1a and 18s reactions was 102% and 95%, respectively (Fujita et al, 2021; Van Essen et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Alkylation of Benz[a]anthracene Affects Toxicity to Early–Life Stage Zebrafish and In Vitro Aryl Hydrocarbon Receptor 2 Transactivation in a Position‐Dependent Manner

Dubiel

Green

Raza

et al. 2022

Enviro Toxic and Chemistry

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Polycyclic aromatic hydrocarbons (PAHs) are structurally diverse organic chemicals that can have adverse effects on the health of fishes through activation of aryl hydrocarbon receptor 2 (AhR2). They are ubiquitous in the environment, but alkyl PAHs are more abundant in some environmental matrices. However, relatively little is known regarding the effects of alkylation on the toxicity of PAHs to fishes in vivo and how this relates to potency for activation of AhR2 in vitro. Therefore, the objectives of the present study were to determine the toxicity of benz[a]anthracene and three alkylated homologs representing various alkylation positions to early life stages of zebrafish (Danio rerio) and to assess the potency of each for activation of the zebrafish AhR2 in a standardized in vitro AhR transactivation assay. Exposure of embryos to each of the PAHs caused a dose‐dependent increase in mortality and malformations characteristic of AhR2 activation. Each alkyl homolog had in vivo toxicities and in vitro AhR2 activation potencies different from those of the parent PAH in a position‐dependent manner. However, there was no statistically significant linear relationship between responses measured in these assays. The results suggest a need for further investigation into the effect of alkylation on the toxicity of PAHs to fishes and greater consideration of the contribution of alkylated homologs in ecological risk assessments. Environ Toxicol Chem 2022;41:1993–2002. © 2022 SETAC

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“…However, changes in gene expression might have occurred at an earlier time during development and been transient. In a study of effects of the brominated flame retardant, TBCO, on ELS of zebrafish, mRNA abundances of these genes were not different at 120 hpf but there was a trend of lesser mRNA abundances at 48 hpf . Alternatively, the mechanism of improper development of the swim bladder might have been cardiotoxicity, behavioral alteration, or thyroid disruption.…”

Section: Resultsmentioning

confidence: 99%

“…In a study of effects of the brominated flame retardant, TBCO, on ELS of zebrafish, mRNA abundances of these genes were not different at 120 hpf but there was a trend of lesser mRNA abundances at 48 hpf. 61 Alternatively, the mechanism of improper development of the swim bladder might have been cardiotoxicity, behavioral alteration, or thyroid disruption. Conventional oil WAFs have been demonstrated to disrupt thyroid hormones in zebrafish ELS, 62 and thyroid disruption has been shown to increase the incidences of uninflated swim bladders in zebrafish ELS following exposure to halogenated chemicals.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Toxicity of Weathered Sediment-Bound Dilbit to Early Life Stages of Zebrafish (Danio rerio)

Everitt

Fujita

MacPherson

et al. 2021

Environ. Sci. Technol.

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Due to high viscosity, bitumen extracted from the Alberta oil sands is diluted with natural gas condensates to form diluted bitumen (dilbit) to facilitate transport through pipelines. Dilbit that is spilled into or near a waterbody is subject to environmental weathering processes such as evaporation and interaction with sediments. This is the first study that assessed the toxicity of weathered sediment-bound dilbit (WSD) to fish early life stages. Exposure of zebrafish (Danio rerio) embryos to water-soluble fractions (WSFs) or water-accommodated fractions (WAFs) of WSD from 30 min to 120 h postfertilization resulted in pericardial edema, yolk sac edema, and incidences of uninflated swim bladder. The presence of oil-mineral aggregates (OMAs) in the WAFs greatly increased toxicity, despite all fractions having similar concentrations of dissolved polycyclic aromatic hydrocarbons (PAHs). There were greater cyp1a mRNA abundances in larvae exposed to WAFs, suggesting that there were differences in bioavailability of PAHs between fractions. However, there was little evidence that embryotoxicity was caused by oxidative stress. Results suggest that evaporation and sediment interaction do not completely attenuate toxicity of dilbit to zebrafish early life stages, and OMAs in exposures exacerbate toxicity.

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Effects of the brominated flame retardant, TBCO, on development of zebrafish (Danio rerio) embryos

Cited by 9 publications

References 46 publications

Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish

Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish

Alkylation of Benz[a]anthracene Affects Toxicity to Early–Life Stage Zebrafish and In Vitro Aryl Hydrocarbon Receptor 2 Transactivation in a Position‐Dependent Manner

Toxicity of Weathered Sediment-Bound Dilbit to Early Life Stages of Zebrafish (Danio rerio)

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