Effects of the Calcium Antagonist Nicardipine on Renal Function and Renin Release in Dogs

Abe, Youichi; Komori, Tadamitsu; Miura, Katsuyuki; Takada, Toyokazu; Imanishi, Masahito; Okahara, Takeshi; Yamamoto, Kenjiro

doi:10.1097/00005344-198303000-00015

Cited by 108 publications

(56 citation statements)

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“…9 Nicardipine affects various renal parameters related to the release mechanism of renin; vasodilation and stimulation of the afferent baroreceptor and also the macula densa, which may respond to changes in sodium and chloride delivery. 10 However, in the present study, renin-angiotensin-aldosterone system was not activated by nicardipine during isoflurane or sevoflurane anesthesia except for angiotensin I in isoflurane anesthesia. These results suggest that activation of the renin-angiotensin-aldosterone system by nicardipine might be inhibited during isoflurane and sevoflurane anesthesia with more completely inhibited in sevoflurane anesthesia.…”

Section: Discussioncontrasting

confidence: 64%

Nicardipine did not activate renin-angiotensin-aldosterone system during isoflurane or sevoflurane anesthesia

Nishiyama

Hanaoka

2000

Can J Anesth/J Can Anesth

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Section: Discussioncontrasting

confidence: 64%

Nicardipine did not activate renin-angiotensin-aldosterone system during isoflurane or sevoflurane anesthesia

Nishiyama

Hanaoka

2000

Can J Anesth/J Can Anesth

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“…Nicardipine has been shown to have a diuretic effect in dogs (Abe et al, 1983), and this effect has been reported for nifedipine in humans (Yokoyama & Kaburagi, 1981).…”

Section: Introduction Methodsmentioning

confidence: 79%

Antihypertensive and renal effects of nicardipine.

Schaik¹,

Nistelrooy²,

Geyskes³

1984

Brit J Clinical Pharma

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Both the acute blood pressure lowering and renal effects of the calcium antagonist nicardipine and those after 1 week's treatment were investigated in 10 normotensive volunteers and in 10 patients with mild to moderate essential hypertension. 2 After 1 week of placebo, nicardipine was administered orally for 1 week (20 mg three times daily), Investigations, done on the first and last day of nicardipine treatment were compared with those on the last day of placebo. 3 During water loading, nicardipine increased urinary volume and urinary excretion of sodium significantly after 1 week nicardipine treatment. 4 In the normotensive group the natriuretic effect was caused by a decrease of fractional proximal and distal reabsorption of sodium. In the hypertensive group the natriuresis was achieved mainly by an increase of the rate of glomerular filtration (GFR) and also by a slight distal effect. 5 Our results show that nicardipine had natriuretic effects. There were trends suggesting that the renal effects may differ between patients with essential hypertension and normotensive volunteers, but the findings might also be related to differences in age between the groups.

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“…Increased ERPF, preferential redistribution of blood flow to juxtamedullary nephrons, 46 or merely physical factors, such as the decline in peritubular oncotic pressure secondary to reduced filtration fraction, 47 may explain the suppression of proximal reabsorption observed in the F(+) subjects after nifedipine administration. On the other hand, it has been observed in both animal 48 -50 and human 51 experiments that calcium entry blocking drugs can suppress reabsorption in either proximal 51 or postproximal 50 tubular sites without changing ERPF or GFR, thus suggesting a direct inhibitory effect of these drugs on tubular transport.…”

mentioning

confidence: 99%

Abnormal renal responses to calcium entry blockade in normotensive offspring of hypertensive parents.

et al. 1988

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SUMMARYIn nine young normotensive subjects with no family history of hypertension and nine age-matched normotensive subjects with one parent with essential hypertension, effective renal plasma Sow (p-aminohippuric acid clearance), gtomerular filtration rate (inuHn clearance), and excretion of sodium and exogenously administered lithium were measured for 90 minutes before and after administration of a single 20-mg oral dose of the calcium entry blocker nifedipine. Segments! tubular handling of fluid and sodium was estimated using lithium clearance as a marker of proximal tubular reabsorption. Nifedipine did not cause any change in subjects with no family history of hypertension, but in those with one hypertensive parent there was a marked increase hi effective renal plasma flow (from 644 ± 39 to 847 ± 42 [SEM] ml/min x 1.73 m J ; p < 0.001) and a decrease In filtration fraction (from 17.6 ± 1.0 to 12.6 ± 0.4%; p < 0.001), while the glomerular filtration rate was unchanged, thus suggesting a prevailing efferent vasodilation. Sodium excretion rate (p < 0.02) and fractional sodium excretion (p < 0.025) increased slightly but significantly in subjects with one hypertensive parent, but not in normotensive subjects with no family history of hypertension. Lithium clearance also rose (from 29.0 ± 2.0 to 32.8 ± 1 . 9 ml/min, p < 0.001), and the derived value of fractional proximal reabsorption diminished (from 75.8 ± 1.0 to 71.3 ± 1.2%, p < 0.001). Estimated distal delivery of sodium and absolute distal sodium reabsorption both increased significantly (p < 0.005), while fractional distal sodium reabsorption was unchanged. Our data show an exaggerated'renal vasodilator response to calcium entry blockade in young normotensive subjects with one hypertensive parent that may be related to an abnormality in the efferent arteriolar tone sensitive to calcium entry blockade. 1 A number of studies in prehypertensive subjects, such as young normotensive members of hypertensive families, have been conducted to investigate functional disturbances preceding the onset of high blood pressure (BP) that may be involved in the pathophysiology of essential hypertension. Indeed, several abnormalities have been

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Effects of the Calcium Antagonist Nicardipine on Renal Function and Renin Release in Dogs

Cited by 108 publications

References 0 publications

Nicardipine did not activate renin-angiotensin-aldosterone system during isoflurane or sevoflurane anesthesia

Nicardipine did not activate renin-angiotensin-aldosterone system during isoflurane or sevoflurane anesthesia

Antihypertensive and renal effects of nicardipine.

Abnormal renal responses to calcium entry blockade in normotensive offspring of hypertensive parents.

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