2021
DOI: 10.1186/s12913-021-07139-z
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Effects of the cefazolin shortage on the sales, cost, and appropriate use of other antimicrobials

Abstract: Background Shortages of antimicrobials lead to treatment failures, increase medical costs, and accelerate the development of antimicrobial resistance. We evaluated the effects of the serious cefazolin shortage in 2019 in Japan on the sales, costs, and appropriate use of other antimicrobials. Methods We evaluated monthly defined daily doses/1000 inhabitants/day (DID) values of antimicrobial sales from January 2016 to December 2019 using wholesaler’s… Show more

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Cited by 11 publications
(9 citation statements)
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“…We chose to analyze data from 2013 as Japan’s AMR national action plan was developed based on AMU data from 2013 4 . We did not include data from 2019 or later due to the occurrence of events that could have affected parenteral AMU in Japan, such as a cefazolin shortage and the COVID-19 pandemic 26 , 27 . Parenteral antimicrobials were identified using the World Health Organization’s Anatomical Therapeutic Chemical code J01 7 .…”
Section: Methodsmentioning
confidence: 99%
“…We chose to analyze data from 2013 as Japan’s AMR national action plan was developed based on AMU data from 2013 4 . We did not include data from 2019 or later due to the occurrence of events that could have affected parenteral AMU in Japan, such as a cefazolin shortage and the COVID-19 pandemic 26 , 27 . Parenteral antimicrobials were identified using the World Health Organization’s Anatomical Therapeutic Chemical code J01 7 .…”
Section: Methodsmentioning
confidence: 99%
“…The NDB contains nationwide medical data from the Japanese health insurance system since April 2009 19,20 . National population age structure data from 2013 to 2019 were obtained from the Statistics Bureau, Ministry of Internal Affairs and Communications of Japan 21 . Population projections from 2020 to 2030 were acquired from the National Institute of Population and Social Security Research 21 , which provides three separate population projections calculated according to low, intermediate, and high birth rates and death rates.…”
Section: Study Datamentioning
confidence: 99%
“…National population age structure data from 2013 to 2019 were obtained from the Statistics Bureau, Ministry of Internal Affairs and Communications of Japan 21 . Population projections from 2020 to 2030 were acquired from the National Institute of Population and Social Security Research 21 , which provides three separate population projections calculated according to low, intermediate, and high birth rates and death rates. For this study, we used the population projection based on intermediate values (The differences in these three projections until 2030 were marginal) 22 .…”
Section: Study Datamentioning
confidence: 99%
“…As summarized by Shafiq et al, many essential antibiotics (including cefazolin) are in short supply at different times across different countries [4]. This antibiotic shortage has posed a global health threat [4,5]. The shortage is associated with a lack of access to effective therapies and associated increased mortality.…”
Section: Introductionmentioning
confidence: 99%