2003
DOI: 10.1038/sj.bjp.0705451
|View full text |Cite
|
Sign up to set email alerts
|

Effects of the CGRP receptor antagonist BIBN4096BS on capsaicin‐induced carotid haemodynamic changes in anaesthetised pigs

Abstract: 1 Calcitonin gene-related peptide (CGRP), a potent vasodilator released from capsaicin-sensitive trigeminal sensory nerves, seems to be involved in the pathogenesis of migraine. Hence, CGRP receptor antagonists may serve as a novel treatment for migraine. This study was therefore designed to investigate the effects of BIBN4096BS (100, 300 and 1000 mg kg À1 , i.v.), a potent and selective CGRP receptor antagonist, on capsaicin-induced carotid haemodynamic changes in anaesthetised pigs. Both vagosympathetic trun… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
38
0

Year Published

2005
2005
2021
2021

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 43 publications
(41 citation statements)
references
References 47 publications
3
38
0
Order By: Relevance
“…In contrast, capsaicin had no effect on MAP or HR in TRPV1 null mice, reinforcing the TRPV1-mediated effects of capsaicin in control and db/db mice. In agreement with our present findings, similar effects to intravenous capsaicin injection have been observed previously in pigs (19) and mice (29).The observed effects were not due to an altered vasoconstrictor response, as PE responses were not different between db/db and control mice. Interestingly, PE responses were significantly attenuated in TRPV1 KO mice.…”
Section: Discussionsupporting
confidence: 82%
“…In contrast, capsaicin had no effect on MAP or HR in TRPV1 null mice, reinforcing the TRPV1-mediated effects of capsaicin in control and db/db mice. In agreement with our present findings, similar effects to intravenous capsaicin injection have been observed previously in pigs (19) and mice (29).The observed effects were not due to an altered vasoconstrictor response, as PE responses were not different between db/db and control mice. Interestingly, PE responses were significantly attenuated in TRPV1 KO mice.…”
Section: Discussionsupporting
confidence: 82%
“…The current study examined whether coronary dysfunction in diabetes is coupled to impaired contribution of coronary TRPV1 channels. TRPV1-mediated changes in blood flow in various vascular beds have previously been demonstrated (24). In contrast, capsaicin had no effect on blood flow in TRPV1 (Ϫ/Ϫ) mice (34).…”
Section: Discussionmentioning
confidence: 84%
“…In pigs, increases in blood flow induced by TRPV1-mediated release of CGRP were dose-dependently inhibited by intravenous BIBN4096BS but not maximally at the highest dose (1 mg/kg) tested (Kapoor et al, 2003). In rats, no changes in heart rate, mean arterial pressure, systemic vascular conductance, or cardiac output were observed with BIBN4096BS at 3 mg/kg (Arulmani et al, 2004).…”
Section: Doses Of Bibn4096bs In Comparison With Other Studiesmentioning
confidence: 84%