Effects of the chronic exposure to cerium dioxide nanoparticles in Oncorhynchus mykiss: Assessment of oxidative stress, neurotoxicity and histological alterations

Correia, Alberto Teodorico; Rebelo, D.; Marques, Joseane Aparecida; Nunes, Bruno

doi:10.1016/j.etap.2019.02.012

Cited by 29 publications

(11 citation statements)

References 90 publications

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“…Long-term exposure of Daphnia to natural REE-enriched mine tailing leachates resulted in a larger number of offspring that was smaller in size when compared to the control, indicating that Ln might induce adverse effects in natural conditions [101]. The gills and liver of fish may also be adversely affected upon long-term exposure to CeO 2 NPs [102].…”

Section: Toxicity To Aquatic Biotamentioning

confidence: 99%

Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis

et al. 2020

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Lanthanides (Ln), applied mostly in the form of nanoparticles (NPs), are critical to emerging high-tech and green energy industries due to their distinct physicochemical properties. The resulting anthropogenic input of Ln and Ln-based NPs into aquatic environment might create a problem of emerging contaminants. Thus, information on the biological effects of Ln and Ln-based NPs is urgently needed for relevant environmental risk assessment. In this mini-review, we made a bibliometric survey on existing scientific literature with the main aim of identifying the most important data gaps on Ln and Ln-based nanoparticles’ toxicity to aquatic biota. We report that the most studied Ln for ecotoxicity are Ce and Ln, whereas practically no information was found for Nd, Tb, Tm, and Yb. We also discuss the challenges of the research on Ln ecotoxicity, such as relevance of nominal versus bioavailable concentrations of Ln, and point out future research needs (long-term toxicity to aquatic biota and toxic effects of Ln to bottom-dwelling species).

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Section: Toxicity To Aquatic Biotamentioning

confidence: 99%

Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis

et al. 2020

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“…This is why the medicine is called "smart" and makes CeO 2 a promising agent for use in nanomedicine [30][31][32][33][34][35]. In particular, it allows one to stabilize the wound environment to neutralize reactive oxygen species or any other free radicals, providing antioxidant, antibacterial, and anti-inflammatory effects [1,26,[35][36][37]. The effect of electron transfer can be repeated many times as the wound discharge penetrates through the polysaccharide hydrogel structure directly to the CeO 2 nanoparticles, or if the wound flora changes.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

et al. 2020

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High-quality and aesthetic wound healing, as well as effective medical support of this process, continue to be relevant. This study aims to evaluate the medical efficacy of a novel smart polymeric nanodrug (SPN) on the rate and mechanism of wound healing in experimental animals. The study was carried out in male Wistar rats (aged 8–9 months). In these animals, identical square wounds down to the fascia were made in non-sterile conditions on the back on both sides of the vertebra. SPN was used for the treatment of one wound, and the other wound was left without treatment (control group). Biocompatible citrate-stabilized cerium oxide nanoparticles integrated into a polysaccharide hydrogel matrix containing natural and synthetic polysaccharide polymers (pectin, alginate, chitosan, agar-agar, water-soluble cellulose derivatives) were used as the therapeutic agent. Changes in the wound sizes (area, volume) over time and wound temperature were assessed on Days 0, 1, 3, 5, 7, and 14. Histological examination of the wounds was performed on Days 3, 7, and 14. The study showed that the use of SPN accelerated wound healing in comparison with control wounds by inhibiting the inflammatory response, which was measured by a decreased number of white blood cells in SPN-treated wounds. It also accelerated the development of fibroblasts, with an early onset of new collagen synthesis, which eventually led to the formation of more tender postoperative scars. Thus, the study demonstrated that the use of SPN for the treatment of wounds was effective and promising.

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“…While, Gagnon et al (2018) represented that contaminated surface water with n-CeO 2 showed immunotoxicity signs and accumulation in high levels at rainbow trout gills. Moreover, Correia et al (2019) investigated that exposed rainbow trout to the highest levels of n-CeO 2 (0.1 mg L -1 ) for 28 days significantly increase the liver CAT activity as well as caused marked histopathological alters in the hepatocytes cells (e.g. pyknotic nucleus, hepatocyte vacuolization, hyperemia and enlargement of sinusoids) and gills (e.g.…”

Section: Finfish Speciesmentioning

confidence: 99%

“…For instance, n-CeO 2 elicited genotoxic effects in Daphnia magna (García et al, 2011), and growth-inhibitory impacts in Pseudokirchneriella subcapitata (Rodea-Palomares et al, 2010). Besides, its oxidative stress effects in Corophium volutator (Dogra et al, 2016), mild cytotoxic and cardiac toxicity in the white sucker fish (Catostomus commersonii) (Rundle et al, 2016) and immunotoxicity with a high mortality rate of rainbow trout (Oncorhynchus mykiss) (Correia et al, 2019) had been reported.…”

Section: Introductionmentioning

confidence: 99%

The applications of cerium oxide nanoform and its ecotoxicity in the aquatic environment: an updated insight

Naiel

Abdel‐Latif

El‐Hack

et al. 2022

Aquat. Living Resour.

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The widespread usage of nanotechnology in many essential products has raised concerns about the possible release of nanoparticles (NPs) into aquatic habitats. Cerium dioxide (CeO2) has gained the most interest in the worldwide nanotechnology industry of all types of Ce minerals owing to its beneficial uses in a wide range of industry practices such as catalysts, sunscreens, fuel additives, fuel cells, and biomedicine. Besides, it was realized that CeO2 nanoparticles (n-CeO2) have multi-enzyme synthesized properties that create various biological impacts, such as effectively antioxidant towards almost all irritant intracellular reactive oxygen species. Lately, it was discovered that a large amount of n-CeO2 from untreated industrial waste could be released into the aquatic environment and affect all living organisms. In addition, the physical/chemical characteristics, fate, and bioavailability of nanomaterials in the aquatic environment were discovered to be related to the synthesis technique. Thus, there are intended needs in identifying the optimal technique of synthesized CeO2 nanoparticles in order to assess their beneficial use or their potential ecotoxicological impacts on aquatic organisms and humans. Therefore, this review sheds light on the possible threats of n-CeO2 to aquatic creatures as well as its synthesized techniques. Also, it discusses the possible mechanism of n-CeO2 toxicity as well as their potential benefits in the aquaculture industry.

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Effects of the chronic exposure to cerium dioxide nanoparticles in Oncorhynchus mykiss: Assessment of oxidative stress, neurotoxicity and histological alterations

Cited by 29 publications

References 90 publications

Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis

Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

The applications of cerium oxide nanoform and its ecotoxicity in the aquatic environment: an updated insight

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