Effects of the combination of loxoprofen sodium and sodium hyaluronate on osteoarthritis and knee function

Abstract

Purpose: To determine the treatment efficacy of the combination of loxoprofen sodium and sodium hyaluronate in osteoarthritis (OA), and its role in knee joint function.
 Methods: 98 patients with OA admitted to Guang'an People's Hospital, Sichuan, China were allocated into control group (CNG, given loxoprofen sodium n, = 51) and study group (SG, given loxoprofen sodium and sodium hyaluronate, n = 47). Both groups were compared in terms of the levels of inflammatory factor, Lysholm, VAS, WOMAC scores, treatment effects, serum MDA, NO, SOD levels, adverse effects, and blood rheology indices.
 Results: The study group had higher SOD levels, and higher BALP and BGP than CNG (p < 0.05). SG had lower TRACP-5b and blood rheological indices than CNG (p < 0.05). The difference in the incidence of adverse reactions was not statistically significant between the two groups (p > 0.05).
 Conclusion: The combination of loxoprofen sodium and sodium hyaluronate effectively improves the function and blood rheological indices of knee joints. It reduces the occurrence of adverse reactions and the level of pain in patients with OA, and improves OA prognosis. However further clinical trials are required prior to application in clinical practice.

Effect of intra-articular injection of sodium hyaluronate on knee function and inflammatory state in knee osteoarthritis patients

“…Celecoxib is a highly selective COX inhibitor, and one of the commonly prescribed orthopedic drugs in clinical practice. It relieves inflammation, pain, and at same time, it is associated with a high risk of adverse reactions [18,19]. However, sodium hyaluronate is composed of alternating nacetyl glucosamine, which is a primary component of joints.…”