Effects of the Coronavirus Disease 2019 Pandemic on Motor Symptoms in Parkinson's Disease: An Observational Study

Kainaga, Mitsuhiro; Shirota, Yasuhiko; Kodama, Satoshi; Toda, Tatsushi; Hamada, Masashi

doi:10.1002/mds.28766

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…Although our data support previous reports on increasing symptom burden, it also documents the long-lasting deterioration that spans periods of low SARS-CoV-2 incidence rates and minimum disease control restrictions. Similar to patient-reported worsening, trend analyses of motor symptoms (Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] part III) revealed a worsening for 40% of PwP 23 since pandemic onset and doubled disease progression rates (MDS-UPDRS part III points/year) compared to pre-pandemic 15 . However, PwP in this study were mostly selfsufficient with few comorbidities and represent a less severely affected subgroup within the spectrum of PwP in Germany.…”

Section: Discussionmentioning

confidence: 82%

Long‐Lasting Impact of the COVID‐19 Pandemic on Patients with Parkinson's Disease and Their Relatives

Wolff

Haller

Demleitner

et al. 2023

Movement Disord Clin Pract

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Background The coronavirus disease 2019 (COVID‐19) pandemic has heavily impacted medical care of patients with Parkinson's disease (PwP). Objective To assess the longitudinal impact of the COVID‐19 pandemic on PwP and their relatives in Germany. Methods Two online, nationwide, cross‐sectional surveys were conducted from December 2020 to March 2021 and from July to September 2021. Results A total of 342 PwP and 113 relatives participated. Despite partial resumption of social and group activities, healthcare was continuously disrupted during times of loosened restrictions. Respondents’ willingness to use telehealth infrastructure increased, yet the availability remained low. PwP reported worsened symptoms and further deterioration during the pandemic, resulting in an increase in new symptoms and relatives’ burden. We identified patients at particular risk: young patients and those with long disease duration. Conclusions The COVID‐19 pandemic persistently disrupts the care and quality of life of PwP. Although willingness to use telemedicine services has increased, its availability needs to be improved.

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Section: Discussionmentioning

confidence: 82%

Long‐Lasting Impact of the COVID‐19 Pandemic on Patients with Parkinson's Disease and Their Relatives

Wolff

Haller

Demleitner

et al. 2023

Movement Disord Clin Pract

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“…Increased pain may similarly result from increased anxiety but could also be caused by rigidity. Fatigue is a well-known consequence of psychological distress in PD [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Vulnerability of Parkinson’s Patients to COVID-19 and Its Consequences and Effects on Them: A Systematic Review

Rezayi

Katigari

Shahmoradi

et al. 2023

Parkinson's Disease

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Introduction. Parkinson’s disease (PD) is the second most common neurological disorder. Patients with PD were affected by the COVID-19 pandemic in many different ways. This study’s principal purpose is to assess PD patients' vulnerability to COVID-19 and its consequences. Method. This systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines. A thorough search was conducted in the Medline (through PubMed) and Scopus databases from inception to January 30, 2022. The Joanna Briggs Institute (JBI) critical appraisal checklist was used to evaluate the studies. Results. Most of the studies (38%) had been conducted in Italy. Of the total number of studies, 17 (58%) were cross-sectional, seven (22%) were cohort, four (12%) were quasiexperimental, two (6%) were case-control, and one (3%) was a qualitative study. The PD duration in patients ranged from 3.26 to 13.40 years (IQR1: 5.7 yrs., median: 3.688 yrs., and IQR3: 8.815 yrs.). Meanwhile, the sample size ranged from 12 to 30872 participants (IQR1: 46, median: 96, and IQR3: 211). Despite worsening PD symptoms in the targeted population (persons with COVID-19 and Parkinson’s disease), some studies found PD to be a risk factor for more severe COVID-19 disease. There are many adverse effects during the pandemic period in PD patients such as abnormalities of motor, nonmotor functioning, clinical outcomes, activities of daily living, and other outcomes. Conclusion. This study confirmed the negative effect of the COVID-19 pandemic on health-related quality of life and its determinants in patients with PD and their caregivers. Thus, due to the worsening symptoms of PD patients in the current pandemic, these people should be given more care and supervision to minimize their coronavirus exposure.

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“…Conversely, over 40% of respondents of a smaller sample from India reported worsening of PD-related symptoms after 3 weeks of restrictions [ 35 ]. Moreover, 40% of people with PD showed an intensification of motor symptoms in an observational study conducted with the use of the MDS-UPDRS III in Tokyo [ 36 ]. In contrast, a study by Guo et al revealed that almost 80% of patients reported new or worsening PD symptoms during the pandemic, and the change was significantly more severe than at baseline (pre-pandemic period).…”

Section: Discussionmentioning

confidence: 99%

Secondary Impact of COVID-19 Pandemic on People with Parkinson’s Disease—Results of a Polish Online Survey

et al. 2021

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The COVID-19 pandemic causes increased mental stress and decreased mobility, which may affect people with Parkinson’s disease (PD). The study aimed to investigate the secondary impact of the COVID-19 pandemic on the level of activity, quality of life (QoL) and PD-related symptoms. The respondents completed an online survey in Polish in the period from December, 2020 to June, 2021. The questionnaire was completed by 47 participants aged 43 to 90 years (mean 72.1 ± 1.3 years). A total of 94% reported reduced contact with family and friends. Over 90% remained active during the pandemic. However, 55% of people with PD showed subjectively lower level of activity then before the pandemic. Moreover, 36% of the respondents felt afraid to visit a doctor and reported problems with access to medication. Subjective QoL reduction was reported by 80%, and 83% declared worsening of PD symptoms. The post pandemic deterioration of motor symptoms in people with PD did not affect their QoL. However, the deterioration of contacts and feelings of isolation had a significant impact on the decline in quality of life (p = 0.022 and p = 0.009, respectively) and the presence of anxiety (p = 0.035 and p = 0.007, respectively). These results may indicate than greater importance of social and mental factors than fitness and health-related factors in the QoL self-assessment of the people with PD.

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Effects of the Coronavirus Disease 2019 Pandemic on Motor Symptoms in Parkinson's Disease: An Observational Study

Cited by 7 publications

References 7 publications

Long‐Lasting Impact of the COVID‐19 Pandemic on Patients with Parkinson's Disease and Their Relatives

Long‐Lasting Impact of the COVID‐19 Pandemic on Patients with Parkinson's Disease and Their Relatives

Vulnerability of Parkinson’s Patients to COVID-19 and Its Consequences and Effects on Them: A Systematic Review

Secondary Impact of COVID-19 Pandemic on People with Parkinson’s Disease—Results of a Polish Online Survey

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