Effects of the crude venom of the social waspAgelaia vicina on ?-aminobutyric acid and glutamate uptake in synaptosomes from rat cerebral cortex

Pizzo, Andrea B.; Fontana, Andréia Cristina Karklin; Coutinho‐Netto, Joaquim; Santos, Wagner Ferreira dos

doi:10.1002/(sici)1099-0461(2000)14:2<88::aid-jbt4>3.0.co;2-g

Cited by 21 publications

(5 citation statements)

References 53 publications

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“…Additionally, free amino acids were found to inhibit GABA and glutamate uptake. 42 Philanthus triangulum F. wasp venom contains components such as β-PTX and δ-PTX, which show effects on animal glutamatergic neuro-junctions. These components were found to inhibit the uptake of glutamate in the neuromuscular synapse on locusts.…”

Section: Animal Venom As a Potential Source Of Anticonvulsantsmentioning

confidence: 99%

Animal Venoms as Potential Source of Anticonvulsants

Zainal Abidin,

Liew,

Othman

et al. 2024

F1000Res

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Abstract* Epilepsy affects millions of people worldwide, and there is an urgent need to develop safe and effective therapeutic agents. Animal venoms contain diverse bioactive compounds like proteins, peptides, and small molecules, which may possess medicinal properties against epilepsy. In recent years, research has shown that venoms from various organisms such as spiders, ants, bees, wasps, and conus snails have anticonvulsant and antiepileptic effects by targeting specific receptors and ion channels. This review underscores the significance of purified proteins and toxins from these sources as potential therapeutic agents for epilepsy. In conclusion, this review emphasizes the valuable role of animal venoms as a natural resource for further exploration in epilepsy treatment research.

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Section: Animal Venom As a Potential Source Of Anticonvulsantsmentioning

confidence: 99%

Animal Venoms as Potential Source of Anticonvulsants

Zainal Abidin,

Liew,

Othman

et al. 2024

F1000Res

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“…Finally, research on crude venom from the social wasp Agelaia vicina revealed its ability to competitively inhibit high- and low-affinity GABA and glutamate uptake [ 109 ]. This is an important result since diseases such as Stroke, Epilepsy and PD involve abnormalities in GABA and glutamate uptake systems [ 110 , 111 ].…”

Section: Venoms and Toxins From Wasps And Bees To Combat Neurodegementioning

confidence: 99%

Pharmacological Alternatives for the Treatment of Neurodegenerative Disorders: Wasp and Bee Venoms and Their Components as New Neuroactive Tools

Silva

Monge-Fuentes

Gomes

et al. 2015

Toxins

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Neurodegenerative diseases are relentlessly progressive, severely impacting affected patients, families and society as a whole. Increased life expectancy has made these diseases more common worldwide. Unfortunately, available drugs have insufficient therapeutic effects on many subtypes of these intractable diseases, and adverse effects hamper continued treatment. Wasp and bee venoms and their components are potential means of managing or reducing these effects and provide new alternatives for the control of neurodegenerative diseases. These venoms and their components are well-known and irrefutable sources of neuroprotectors or neuromodulators. In this respect, the present study reviews our current understanding of the mechanisms of action and future prospects regarding the use of new drugs derived from wasp and bee venom in the treatment of major neurodegenerative disorders, including Alzheimer’s Disease, Parkinson’s Disease, Epilepsy, Multiple Sclerosis and Amyotrophic Lateral Sclerosis.

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“…The effect of the denatured venom of Agelaia vicina in cerebrocortical synaptosomes was described [ 94 ]; subsequently, two peptides that act on excitatory and inhibitory neurotransmissions were isolated (AvTx7 and AvTx8) [ 95 , 96 ]. These works thus corroborate the necessity for more complete studies on the micromolecular fractions of wasp venoms to identify and characterize the components responsible for these notorious antiepileptic effects.…”

Section: Reviewmentioning

confidence: 99%

Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders

Monge-Fuentes¹,

Gomes²,

Campos³

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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The impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-image, and self-confidence affected. In spite of their availability, drugs for the treatment of these disorders are commonly associated with side effects, which can vary in frequency and severity. Currently, no effective cure is known. Nowadays, the biopharmaceutical research community widely recognizes arthropod venoms as a rich source of bioactive compounds, providing a plethora of possibilities for the discovery of new neuroactive compounds, opening up novel and attractive opportunities in this field. Several identified molecules with a neuropharmacological profile can act in the central nervous system on different neuronal targets, rendering them useful tools for the study of neurological disorders. In this context, this review aims to describe the current main compounds extracted from arthropod venoms for the treatment of five major existing neurological disorders: stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and pathological anxiety.

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Effects of the crude venom of the social waspAgelaia vicina on ?-aminobutyric acid and glutamate uptake in synaptosomes from rat cerebral cortex

Cited by 21 publications

References 53 publications

Animal Venoms as Potential Source of Anticonvulsants

Animal Venoms as Potential Source of Anticonvulsants

Pharmacological Alternatives for the Treatment of Neurodegenerative Disorders: Wasp and Bee Venoms and Their Components as New Neuroactive Tools

Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders

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