Effects of the dopamine antagonist PD 152255 on juvenile rats' responses to dorsal stimulation, the transport response and related behaviors.

Abstract

The authors gave 23- and 40-day-old rats doses of the dopamine D3 antagonist PD 152255 and tested them on transport response intensity, vertical cling catalepsy duration, and dorsal immobility duration. Administration of PD 152255 resulted in dose-dependent increases in transport response intensity in 40-day-old rats but was without effect in 23-day-old rats. Administration of PD 152255 caused increases in dorsal immobility durations in both 23- and 40-day-old subjects. The drug was without effect on vertical cling catalepsy. Results are discussed with respect to the role of D3 receptors in the transport response and the nature of D2-D3 receptor interactions.

Differential Effect of the DopamineD3Agonist (±)-7-Hydroxy-2-(N,N-di-n-propylamino) Tetralin (7-OH-DPAT) on Motor Activity between Adult Wistar and Sprague-Dawley Rats after a Neonatal Ventral Hippocampus Lesion

“…In rats, the D 3 receptor is mostly distributed in projection areas of the mesocorticolimbic dopaminergic system, for example, the nucleus accumbens, olfactory tubercle, islands of Calleja, and prefrontal cortex [ 3 – 6 ]. Although the role of the D 3 receptor in the brain function has not been completely established, it has been related to behavioral aspects such as locomotion, emotion, and cognition [ 6 – 11 ]. The D 3 receptor has also been implicated in disorders, such as schizophrenia and drug abuse, because its pharmacology and pattern of location in the brain is consistent with defective neural circuits seen in such disorders [ 12 , 13 ].…”