Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice

Zhang, Weiyun; Li, Jing; Qiu, Shuiqing; Chen, Jiaping; Zheng, Yi

doi:10.1016/j.fitote.2007.09.001

Cited by 61 publications

(35 citation statements)

References 25 publications

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“…These included polysaccharides obtained from G. pentaphyllum Makino (96), a polysaccharide isolated from Artemisia apiacea (97), and oral administration of A. coreanum (98). Polysaccharides obtained from cultured Cordyceps fungus have also been shown to have pharmacological efficacy; specifically, the exopolysaccharide fraction from Cordyceps sinensis was found to significantly inhibit HCC tumor growth and lead to elevated TNF-α and IFN-γ mRNA expression of splenic lymphocytes (99). Collectively, these data indicate the increasing contribution to therapeutic effects of these polysaccharides.…”

Section: Polysaccharides Targeting Pro-inflammatory Cytokinesmentioning

confidence: 99%

“…Since then numerous studies have suggested that polysaccharides can be utilized as key ingredients for bio-based materials in life sciences, including pharmaceuticals, and many polysaccharides have demonstrated potential as anticancer agents (96)(97)(98)(99). With regard to drawbacks, such as low safety profiles and resistance of current therapies, the development of polysaccharides as treatment strategies for HCC is necessary.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides

et al. 2017

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Abstract. Hepatocellular carcinoma (HCC) has become a leading cause of cancer-associated mortality worldwide and is thus of great concern. Although various chemotherapeutic drugs are currently used for the treatment of HCC, severe side effects associated with these treatments have prompted interest in novel therapies, including the use of certain biological macromolecules such as polysaccharides. Several studies have shown that polysaccharides have anticancer and antiproliferative effects on HCC. Vascular endothelial growth factor, transforming growth factor β, epidermal growth factor and fibroblast growth factor may be effective targets for polysaccharides and may modulate tumor growth and immunity through increasing the expression levels of cytokines. The present review focuses on the ways in which growth factors contribute to the development of HCC, and on the anti-growth factor activities of natural and synthetic polysaccharides, as well as their effect on proinflammatory cytokines.

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Section: Polysaccharides Targeting Pro-inflammatory Cytokinesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides

et al. 2017

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“…sinensis is traditionally used (Wang and Shiao, 2000;Seth et al, 2014) for anti-inflammation (Yang et al, 2011;Wang et al, 2012), antimicrobial activity (Negi et al, 2014;Mamta Mehrotra et al, 2015), antidiabetic (Kiho et al, 1999;Balon et al, 2002;Lo et al, 2004;Li et al, 2006;Zhang et al, 2006;Shi et al, 2009;El Ashry et al, 2012), antitumor activity (Bok et al, 1999;Zhang et al, 2004), antimetastatic (Nakamura et al, 1999), immunomodulatory (Gong et al, 1990), hypocholesterolemia (Koh et al, 2003), and antioxidant activities (Yamaguchi et al, 2000;Li et al, 2002;Dong and Yao, 2007;Wang et al, 2009), and associated diseases such as hepatic diseases (Liu and Shen, 2003) and chronic kidney diseases . Meena et al (2013) reported that laboratory cultured mycelia powder of O. sinensis is safe and non-toxic up to 2g/kg body weight dose.…”

Section: Traditional Usesmentioning

confidence: 99%

Antihyperglycemic activity of Ophiocordyceps sinensis: A Review

Sirisidthi

Kosai

Jiraungkoorskul

2015

IJARe

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Diabetes mellitus, one of the non-communicable diseases, is still the seriously problem due to leading the causes of death in the developed countries. Therefore it is important to identify novel nutraceuticals or drugs for curing or preventing diabetes because the existing synthetic drugs have several limitations. Traditional medicinal plants and medicinal mushrooms are used in the treatment of diabetes mellitus more than century, but only a few of these have proofed their safe and efficacy. Aim of this review article is focused Ophiocordyceps sinensis one of the edible and medicinal mushrooms used for therapeutic effects and antioxidant activities. It contains several kinds of polysaccharides, proteins, nitrogen compounds, fatty acids, phenolic acids, and isoflavones. Many researches have evaluated that these phytochemical substances have the major impact on diabetes mellitus. This review focuses on the antihyperglycemic activity of this mushroom and clears that it has the potential to be considered as a candidate for preparing the new treatment of diabetes mellitus.

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“…EPSF significantly promoted macrophages' TNF-alpha expression and spleen lymphocytes' cytotoxicity. EPSF also significantly elevated TNFalpha and IFN-gamma mRNA expression of splenic lymphocytes and thus elevated immunocytes' activity in H22 tumor bearing mice [21,22]. The EPSF from C. sinensis also has inhibitory effect on oncogene expression.…”

Section: Activity Of Cordyceps Sinensismentioning

confidence: 99%

“…Two new epipolythiodioxopiperazines, named gliocladicillins A and B, from Cordyceps-colonizing fungi inhibited growth of HeLa, HepG2 and MCF-7 tumor cells by arresting the cell cycle at G(2)/M phase and induced apoptosis through up-regulation of expression of p53, p21, and cyclin B and activation of caspases-8, -9 and -3 [31]. Furthermore, EPSF of C. sinensis decreased the levels of Bcl-2 in the lungs and livers [22]. The antitumor activity of C. sinensis by inducing apoptosis was also found in human colorectal (HT-29 and HCT 116), hepatocellular (Hep 3B and Hep G2) carcinoma cells [32] and human oral squamous cancer cell line (OEC-M1) [33].…”

Section: Activity Of Cordyceps Sinensismentioning

confidence: 99%

Cordyceps Mushroom: A Potent Anticancer Nutraceutical

Khan¹,

Tania²,

Zhang³

et al. 2010

TONUTRAJ

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Abstract:The Cordyceps mushrooms have a long history as medicinal fungi. In Traditional Chinese Medicine, Cordyceps have been used to treat several conditions including cancers for thousand of years. Extracts from both mycelium and fruiting bodies of C. sinensis, C. militaris and other Cordyceps species showed significant anticancer activities by various mechanisms such as, modulating immune system and inducing cell apoptosis. Some polysaccharide components and cordycepin (3'-deoxyadenosine) have been isolated from C. sinensis and C. militaris, which acted as potent anticancer components. This review article aims to further elucidate the importance of Cordyceps mushrooms by summarizing the findings of some of the important research works concerning possible mechanism of anticancer activity of this mushroom.

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Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice

Cited by 61 publications

References 25 publications

Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides

Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides

Antihyperglycemic activity of Ophiocordyceps sinensis: A Review

Cordyceps Mushroom: A Potent Anticancer Nutraceutical

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