Effects of the Female Estrous Cycle on the Sexual Behaviors and Ultrasonic Vocalizations of Male C57BL/6 and Autistic BTBR T+ tf/J Mice

Kim, Hyopil; Son, Junehee; Yoo, Hyoungseob; Kim, Hakyoo; Oh, Jihae; Han, Daehee; Hwang, Young Hwan; Kaang, Bong Kiun

doi:10.5607/en.2016.25.4.156

Cited by 30 publications

(29 citation statements)

References 33 publications

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“…We collected urine twice daily from animals over the course of two months to generate a pool that included both diestrus and estrous urine. Similar to other strains like male C57Bl/6 and male BTBR T+ tf [67], the strain used in our lab (i.e., CBA/J), do not change the number or rate of USVs produced with female reproductive state [12] (but see [68]). Rather, male CBA/Js produce USVs of longer duration, greater bandwidth and higher frequency when engaging with estrous versus diestrus females.…”

Section: Plos Onesupporting

confidence: 64%

Male mice adjust courtship behavior in response to female multimodal signals

et al. 2020

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Multimodal signaling is nearly ubiquitous across animal taxa. While much research has focused on male signal production contributing to female mate-choice or preferences, females often give their own multimodal signals during intersexual communication events. Multimodal signal components are often classified based on whether they contain redundant information (e.g., the backup hypothesis) or non-redundant information (e.g., the multiple messages hypothesis) from the perspective of the receiver. We investigated the role of two different female vocalizations produced by the female house mouse (Mus musculus): the broadband, relatively low-frequency squeaks (broadband vocalizations or BBVs,), and the higher-frequency ultrasonic vocalizations (USVs). These female vocalizations may convey differently valenced information to the male receivers. We paired these vocalizations with and without female urine to examine the influence of combining information across multiple modalities. We found evidence that female urine and vocalizations act as non-redundant multimodal cues as males responded with different behaviors and vocalization rates depending on the female signal presented. Additionally, male mice responded with greater courtship effort to the multimodal combination of female USVs paired with female urine than any other signal combination. These results suggest that the olfactory information contained in female urine provides the context by which males can then evaluate potentially ambiguous female vocalizations.

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Section: Plos Onesupporting

confidence: 64%

Male mice adjust courtship behavior in response to female multimodal signals

et al. 2020

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“…However, all studies of APN actions in neurodegenerative diseases have been performed in male mice to exclude the effects of the estrous cycle on behavioral and psychiatric states, including mood, anxiety, learning, and memory 7, 8, 32, 64. Thus, a study is required for comparison of the effects of APN in male and female mice.…”

Section: Differential Action Of Apn In Rodents and Humansmentioning

confidence: 99%

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Waragai

Ho²,

Takamatsu

et al. 2017

Ann Clin Transl Neurol

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A recent study suggested that insulin resistance may play a central role in the pathogenesis of Alzheimer's disease (AD). In this regard, it is of note that upregulation of plasma adiponectin (APN), a benign adipokine that sensitizes the insulin receptor signaling pathway and suppresses inflammation, has recently been associated with the severities of amyloid deposits and cognitive deficits in the elderly, suggesting that APN may enhance the risk of AD. These results are unanticipated because AD has been linked to type II diabetes and other metabolic disorders in which hypoadiponectinemia has been firmly established, and because APN ameliorated neuropathological features in a mouse model of neurodegeneration. Therefore, the objective of this study is to discuss the possible mechanisms underlying the biological actions of APN in the context of AD. Given that insulin receptor signaling is required for normal function of the nervous system, we predict that APN may be upregulated to compensate for compromised activity of the insulin receptor signaling pathway. However, increased APN might be sequestered by tau in the brain, leading to neurotoxic protein aggregation in AD. Alternatively, misfolding of APN may result in downregulation of the insulin/APN signal transduction network, leading to decreased neuroprotective and neurotrophic activities. Thus, it is possible that both ‘gain of function’ and ‘loss of function’ of APN may underlie synaptic dysfunction and neuronal cell death in AD. Such a unique biological mechanism underlying APN function in AD may require a novel therapeutic strategy that is distinct from previous treatment for metabolic disorders.

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“…The estrus stage was determined (McLean et al, 2012), revealing that 31% of recordings occurred with a female in estrus or proestrus. However, a previous study found no correlation between the number of syllables emitted and female estrus state (Kim et al, 2016). …”

Section: Methodsmentioning

confidence: 89%

Social Ultrasonic Vocalization in Awake Head-Restrained Mouse

Weiner

Hertz

Perets

et al. 2016

Front. Behav. Neurosci.

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Numerous animal species emit vocalizations in response to various social stimuli. The neural basis of vocal communication has been investigated in monkeys, songbirds, rats, bats, and invertebrates resulting in deep insights into motor control, neural coding, and learning. Mice, which recently became very popular as a model system for mammalian neuroscience, also utilize ultrasonic vocalizations (USVs) during mating behavior. However, our knowledge is lacking of both the behavior and its underlying neural mechanism. We developed a novel method for head-restrained male mice (HRMM) to interact with non-restrained female mice (NRFM) and show that mice can emit USVs in this context. We first recorded USVs in a free arena with non-restrained male mice (NRMM) and NRFM. Of the NRMM, which vocalized in the free arena, the majority could be habituated to also vocalize while head-restrained but only when a female mouse was present in proximity. The USVs emitted by HRMM are similar to the USVs of NRMM in the presence of a female mouse in their spectral structure, inter-syllable interval distribution, and USV sequence length, and therefore are interpreted as social USVs. By analyzing the vocalizations of NRMM, we established criteria to predict which individuals are likely to vocalize while head fixed based on the USV rate and average syllable duration. To characterize the USVs emitted by HRMM, we analyzed the syllable composition of HRMM and NRMM and found that USVs emitted by HRMM have a higher proportion of USVs with complex spectral representation, supporting previous studies showing that mice social USVs are context dependent. Our results suggest a way to study the neural mechanisms of production and control of social vocalization in mice using advanced methods requiring head fixation.

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Effects of the Female Estrous Cycle on the Sexual Behaviors and Ultrasonic Vocalizations of Male C57BL/6 and Autistic BTBR T+ tf/J Mice

Cited by 30 publications

References 33 publications

Male mice adjust courtship behavior in response to female multimodal signals

Male mice adjust courtship behavior in response to female multimodal signals

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Social Ultrasonic Vocalization in Awake Head-Restrained Mouse

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